Citicoline ??? ????????? ???? ?????? ?????? ?????
Citicoline??? ????????? ???? ?????? ?????? ?????, ???????, ????????? ??????, ????? ????? ?????? ????? ?????? ????? ???????? ??????, ???? ???? ????????, ???? ?????, ???? ????? ?????????? ??? ????. ?????? ???? ?? ?????????? ???? ?????? ?? ????? ???? ?? ?????? ???????, ???? ???? ?? ???????? ????????????. ????????? ???? ?? ?????? ?? ????? ?????? ???? ??????? ??????? ?? ??????? ?? ???????????? ATPase ??????? ??? Na+/K+ ATPase, ???? ???? ?? ????? ?????. ?? ???, ????????? ??????????????? ?? ????? ??????????????? ??????? ??????? ????? ????????, ?????? ??????, ???? ?????, ???? ????? ??????, ????? ?????? ??????? ?? ?????? ?????? ????? ???-???.
Citicoline???? ????? ?? ???? ??? ?? ??? ????? S-adenosine-L-methionine, ?????? ?? ??????? ????????? ??????? ????? ???? ????? ?? ???? ??????? ???????, ???? ?? ???????? ?? ?????? ??????? ????? ??????, ????? ???????? ???????.
Citicoline ???? ?????? ?? ??? ?????? ????? ???? ???? ?? ??? ????? ????? ????? ???????????????? (CCT) ????? ?? ??????? ?? ?????????? ????? A2(PLA2) ?? ???? ?? ?????? ?? PLA2 ?? ??? ????? TNF-a/IL-1b ??? ?????? ?? ????? ???????? ?? ?????, ?? ??? ?? ?????? ?? ????? ????????, ?????? ????? ???.
Citicoline ???? ?? ?????? ?? ?????? ?? ?????? ????-?????????? ???? Bcl-2 ????? ????? ?????? ??? ?????? ???????????.
????????? ???? ????? ???? ?? ????? ???? ?????? ???????? ???????????, ???? ?? ?????? ???? ?????? ???????, ?????? ?? ????? ?????? ???? ???????, ???? ????? ????????? ?????? ???????? ?????? ??????? ???????.
Citicoline ???? ?????? ?? ???? vasopressin ?????? ???????????, ?????? ????? ?? ?????? ?????, ?????????? ??????? luteinizing.
?????? ????? ???? ???? ?? ???? ?????????, ????? ????? ?????.
???? ??? ????? ???????????. ????? ?? ?? ??? ????? ??? ????? ???? ???? ?????? ?? ?????.
???? ??? ?????? ????? ???????. ???? ??? ????? ????? ??, ????: ??? ?????? ?? ????? ??????? ????????, ???? ????? ?????? ??????, ????? ???? ????? ????, ????? ????? ????, ???? ????? ?????? ?????? ????.
????? ?? ???? ?????? ????????, ??? ????? ???? ???? ???? ???????????????? ????? ??????????. ??? ???? ?? ???? ????? ???????? ????? ??????? ????????. ?????? ??? ????, ????? ????? ??? ???? ?????? ?????. ???? ???? ?? ????? ?????? ?? ???? ????????? ??????? ?? ??? ?????? ???????? ???? ?????: ????? ?????? ??????? ?????? ????? ??????.
???? ??? ???, ??? ???? ???????, ???? ????????? ???? ????? ?????? ????????, ??????? ???? ???, ????? ?? ????? ???-??? ???????? ???? ?-citicolin ?????? ?????? ???????, ?? 80% ??????? ????????????? ?????? ?????? ????????? ????.
?????, ????????? ???? ??????????? ?????? ?????? ??????? ?????? ?????? ?????? ?????. ?????? ???? ?? ????????? ????, ??????? ????????? ????? ?? 90%, ??? ???? ?-1% ????? ????? ???? ??? ????. ???? 2 ???? ????? ??????, ??? ??? ?-24 ???? ???? ??????.
??????? ?? ??????, ???? ?? ????????? ????? ?????????? ??? ?????? ???? 10 ???? ???? ?????? ???? ?????? ????? ???? ????? ???? ?????? ?? ????. ??????? ?????? ?????? ???? 48 ????, ??????? ???? ????, ???? ?? ???? ???? ?????? ??? ??? ??? ???, ???? ??????. ????? ???????? ?? ????????? ????? ???? ????? ???? ?? ????? ??? ????????????? ???????, ????? ?? ????? ??? ???????? ?????????, ????? ????????? ?????.