???????????? ??????? ???? ?? ????? ??????, ?? ?????? ??????????, ???? ???? ??? ???? ??? ?? ???? ???????? ?? 122.12 ????. ??? ???? ?????? ????? ??? ??????, ???????, ?????, ????? ????. ??? ???? ?? ??????? ??????? ??? ???, ???? ????? ????. ??????, ??? ???? ?? ?????? ??? ?? ???? ???? ??? ????? ?????? ???????, ???? ???? [1][2]. ????????? ??? ????? ??????? ??? ??? ??? ????, ??? ?? ?? ??? ?? ????????? ???????? ?? ????? ??????? ????, ??? ?? ??? ??? ?????? ???? ??????? ??????? ??????. ???????? ??? ?? ?? 0.2 ??"?/?', ????????? ??????? ?? 70% ???? ?????? ?? ???????, ?? ????? ???? ?????? ???? ????? ??????? ??? ??????? ?????? ?? ????? ?????? [3]. ?????? ????????????? ???? ?????????? ???? ???? ????? ????? ?????? ????? ?? ?????? ?????? [2]. ?????, 90% ??????????? ????? ????? ???? ???? ?????? ????????? ????? ?????? ???? ????? ??? ?????, ???? ???? ????? ?? ???? ????? ?? ????????? ??? [4]. ????????? ???? ?? ???? ????? ???? ????? ??? ????? ????????? ??????? ??? [5]. ?????? ?????? ???????????? ???? ?? ????????? ????? ????? ???? ??????? ?? ??????? ????? ??? ??????? ????????? ????????.

????, ????????? ????? ????? ?? ??? ????? ???????????. ??????? ??????? ?????, ????? ?????? ?? ????????? ?? ??? ????? ??????????? ??? ????, ?? ?????? ????? ?????? ????? ????? ?? ????? ?????? [4]. ???, ????? ?????? ?? ????? ??? ???????

?????? ???????: ??????? ?? ????????? ????? ???? ??? ?? ???????, ???? 2/3 ???????? ?? ???????. ????????? ??? ???? ???? ???? ?? ????? ????? ?????. ??????? ??????? ???? ????? - ??????? ????, ?????????? ??????? ??????????? ????????? ???? [7,8]. ?????, ???? ????????? ????? ?? ??????? ???? ????? ????? ???? ?????? ????????, ??? ???? ????? ?? ???? ??? ???? ????? ?? ??? ??????? ???? ????? ?????, ?????? ?? ?????-?????? ??????? ?? ??????, ????? ?? ???? ???? ?? ??????, ?? ????? ?? ??????? ????? ???????.

???? ?????? ??? ???: ???????? ?????????? ????? ????, ??-90% ?????? ?????? ?????? ??? ???? ????? ???, ??? ?-10% ?????? ?????? ???? ??? ????? ???? ??????. ?????? ????? ??? ????? ??????? ?????? ???? ????? ?????? ???? ?? ?????????, ?????????? ???? ????? ?????????? ?? ??? ??????? ??????, ????? ???? ??? ?? ???????? ???????? ???? ????? ???????? ???? ??? ????? ????? ?????, ???? ?????? ???? ???? ????? ????????? ????. ??? ????? ????????? ????, ????????? ???? ??? ???? ???? ??? ???? ???? ???? ???????, ?? ??? ???? ????? ?????? ???? ????? ????, ????? ?????? ????? ??? ????? [9]. ??????? ?????????? ???????? ??????? ?? ????????? ???? ?? ???? ?????? ?????. ???? ??????? ?? ????? ????????? ??? ?? 1/10-1/20 ???????, ???? ??????? ??? ??? 0.2-0.4 ????-?'?/?, ??? 5% ?? 10% ???????? ???????, ???? ??????? ?????? ????? ???? ?? ?????????? ?????? ?????.

?????? ????? ??????? ????? ?????: ??? ?????? ??????? ??????? ?? ?????????, ??? ??????? ????? ???? ?????? ????? ??? ?????, ????? ?-10% ???? ???? ????. ?????? ????? ???? ??? ????? ?????? ?????????, ????? ??? ?????? ???? ???? ???? ???? [10]. ???? ??????? ?????? "2007 ??' 12" ?? ????? ????????? "?????? ????? ??????", ?????? ?????? ????? ????? ?? 50 ???, ???? ??????? ????? ??????? ????? ??????, ??? ????? ???? ???? ?????? ?? ?????? ??? ???? ????? ???????? ????.

????? ????? ?????: Yokozawa et al. [11] ??? ?? ?????? ?? ????????? ?? ????? ?????? ?? ??? ?????????????, ???????? ???? ?????????? ???? ?????? ???????? ?? ???? ??????? ?????, ???? ??????? ?? ?????? ????????. ?????? ????? ???? ???? ????? ?????? ?????? ?????? ?? ?????????, ????????? ????? ???? ???? ??????? ???? ????? ????? ?????? ?????? ?????? ??????, ?? ?????? ?? ?? ??????????? ?? ???????? ????? ????? ???????? ????? ??????? ?????????? ???. ???, ????????? ???? ???? ???? ????? ?????? ??????? ??????? [12,13].

???????? ????? ????: Honkala et al. [14] ???? ?? ?????? ?? ????????? ???' ?? ??????? ????? ????? ????? ?????, ???????? ???? ??????? ????????? ??? ????? ????? ????? ?? ???? ??????? ?????, ?????? ??? ???? ????? ???? ?????. ?????? ?????????? ???? ?????? ????? ???? ??????, ?????? ?? ???? ?-Streptococcus mutans ???? ?????? ??????, ???? ?????? ?? ?????? ????? [15]. ?????, ??????? ???? ?? ??????? ?????-???? ?? ????????? ????? ????????: 1. ????? ????? ?????? ?????? ?????? ?? ???? ???????? ???????? ??????? ???????? ????; 2, ?????? ?? ???????? ?? ?????? ??? ??????? ?? ??????????? ????? ???; 3. ???? ?? ???? ????? ?????? ??????????? [16]. ???, ?????????? ?????? ????-???? ???? ????? ??????? ???.