???? ????? ?? ?????????
?????? ???????? ?? ????????? ???? ????? ???? ????? ???????????, ????? ????? ???? ?????? ??????. ????? ??? ??? ??????????? ?? ????? ????? ????, ?????? ???? ??? ??? ??? ????. ???? ???????? ???????? ???????? ??????? ?????? ??????? ?? ?????????:
???? ????? ?????: ???? ????? ???????????
????? ??? ???????
???? ???????: ????? ????????? ???? ????? ???? (???? Moniliella pollinis, Yarrowia lipolytica) ?? ???? (???? Trichosporonoides megachiliensis).
??????????? ?? ????? ?????: ????????? ??????? ????? ?? ??? ????? ?? ??????? ???? ??? ??????? ???? ??????? ???? ?? ??? ??????? ??????? ????? ????.
????? ????? ???
???? ????: ?????? ?????? ?????? ?? ?????? (?? ????? ?? ?? 30-35%, ??????? ????? ???????? ????? ?????? ?????? ?????????).
????? ?????: ????? ??? ????? ??? ????? ???? ?????? ????? ?????? ??????? ??????? ????????? ???????? (α - ?????? + ??????).
????? ??????
????? ?????? ????: ???? ????? ?????? ???? ?????? ????? ??????, ??? ????? ?????? ???? ???????? (5.0-6.0), ????????? (28-34 ℃) ????? ????? ?????.
????????? ?? ??? ??????? ????: ??? ????? ?????? ????, ??????????????? ?????? ??? ???????? ?????????? ??? ???? ?? ???? ???????? ?????.
????? ??????? ?????? ??????
????? ?????? ?? ??????
????? ?????, ?????????? ?? ????????? ????? ??? ??????? ???????? ?????????? ??????
??? ???? ?????? ?? ?? ???? ????????, ??? ????? ????? ???? ????? ??????????
????? ?????, ????? ???????, ????? ?? ?????? ??? → ????? ????? (????? ?? ????? ????? ???? ?????)
????? ??????????, ????? ??????????? ?? ?????? → ????? ????? ????? ????? ?????? ????? ?? ???? ???? ?-99.5%
?????? ????? ????? ???? ???? ??????? (?? ???????)
????? ?????? ??????? ????? ?? ?????, ????????? ???? ????? ???? ?:
?????: ?????, ?????, ????? (?-0.005-0.1%)
?????? ???????: ???? ????, ????
???? ????? ????? (?????? ???? ???? ????):
????????? ?????
????? ???
??? LR
? [????? ??????] -->? [????? ??? ????]
B -->C [??????????? ?? ????? ?????]
C -->D [????? ???????????? ????? ?????]
D -->E [????? ????????? ?-HPLC]
???????: ????? ????? ?????? (??????? ????????? ?? ????? ??????? ???? ???
????????? ??????? ????????/????????
??? ????? ??????/?????? ????????? ????????? (??????)
???? ???????: ?? ?????? (?????? ?? 37 ???/100 ??? ?-25 ????? ??????). ?? ?????? ??? ????????? ??? ????? ???????? ?????.
????? ??????: ??? ???? ???? ???? ???????? (??????? ?????????
????? ?????: ?????? ?????? ?????? ????? ???????????? ????????? ??? ?????? ?? ?????? ????? ???? ????? ?-30%.
????? ?????: ???-??????? ??????? ???? ???? ????? ????, ????? ?? ????? ?????? ?-48 ????.
??????? ?????: ?????????? ??????? ????? ?????????? ????? ?? ???? ????? (>99.9%) ??????? ?? ????? ???????.
?????????
????? "?????" ?? ????????? ?????? ????? ?????? ????? ??????? ????? ????????, ??????? ???? ?? ?????? ???????? ????. ????????? ??????? ?????? ????? ???????? ?????, ????? ?????? ???? ???????? ????? ?????? ??? ????? ????? ????? ????? ?? ??????? ????? ????, ??? ????? ?????? ????? ??? ????. ?? ?????? ??????? ???????? ?? ????? ?? ???? ?? ?????? ?? ????, ???? ???? ????? ??????? ?????.