?????, ?????? ?????? ???????? ????-????'???

???????? ????? ?? ??????, HMB-Ca ???? ??? ?????? ?????? ??????? ??????? ?????? ?????? ????? (????????). ?????? ??????? ????? ?? ?????? ??? ??? 65 ?????? 3 ??? ?? HMB-Ca ??? ???, ?????? ?? ?????? ??????? ??????, ???? 12 ??????, ??? ????? ??????? ?? ?????? ???? ?-1.2 ?"?, ??? ?????? ??? ?-14%, ???? ?????? ??????? ?????? ???? ?-23%34. ?????? ?????? ??? ????:

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????? ????? mTOR: ????? ?????? ?????? ????? ????? ?-38%

????? ????? ?????? ???????????: ????? ?? ?????? ?? ???? ????? ?????? (???? MuRF1) ?-41%

????? ????? ?????: ????? ?? ???? ????? ????-????? IL-6 ?-29% ????? ???? ??????.

????? ?????-????'???, ???? ???????? ?? HMB-Ca ?????? ?? ?????? D3 ??? ?? ??? ????? ???????? ?-17% ?????? ?? ???? ??????? ?????? ????? ???????? ???? (SASP) ?-34%. ????? ?????? ????? ????? ??????? ???? ???? ???? ????? ????? ??? II ?? HMB-Ca ??? ???? ?? ??????? ???? ????????, ??????? ???????? ????? ????? ?? 19% ?????? ?????? ??????????.

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2. ????? ????? ????? ?????? ??????

HMB-Ca ????? ?????? ?????? ????? ?????? ?????? ????? ??????? ????????:

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????? ?????? ?????: ????? ?? 3 ??? ?? HMB-Ca ???? ????? ?? ?????? ???? ????? 3 ?????? ?? ???? ???? ??? ????? ?????? ?? ????? ??? ???? ???? ?-62% ??????? ?? ??????? ?????????? ?-38%.

????? ?????? ??????: 30% ????? ?????? ?? ??? ???? ??????? ??????? ????? ???????? ??????? HMB-Ca, ??? ????? ???? ????? ?-5-7 ???? ???? ????? ?????? ????? ?-41%.

????? ?????? ??????: ????? ????? ?-HMB-Ca ??????? ????? ??????? ????? COPD, 6 ?????? ???? ???, ???? ?????? ?? 6 ???? ??? ?-82 ?????, ????? ????? ?????? ??? ?-21%.

???? ????? ???????? ???????? (FDA) ???? ?? HMB-Ca ?"????? ?????" ?????? ????? ????? ?????? ???? ????, ??????? ??????? ???? III ???? ?? ???? ????? ???? ??????? ????? ?-28% ?????? ????????? ?? ???? ??? ????? ?-19%.

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3. ????? ??? ?????? ????? ????????

????? ???????? ????? ?? HMB-Ca ??????? ???????? ?????????????:

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?????? ?????????: ????? ????? ???? 2 ?????? ????? HMB-Ca ???? 12 ??????, ??? HOMA-IR ??? ?-23% ?????? ??????? ?????? ???? ???? ?-37%.

????? ???????? ?? ????: ?? ??? ????? ????? AMPK, ????? ????????????? ???? ???? ?-29% ???? ??????????? ???? ?-18%.

????? ??????????? ?? ??????: ????? ?????? ???? ????? ????? ??? ?-42% ????? ????? ????? ???? ????? ?-31% ?? ??????? ???? ??????????/?????????.

?????? ????? ??? ????? ?? ?????????, ???? ???????? ?? HMB-Ca ?????? ?? ???????? ????? ?? ???? ????????? ???? ?-1.2 ????? ????? ?? ????? ????????? ?? ALT ?-68% 57. ???? RCT ?????????? ?? ?????? ??????? ???? ????? ?? 19% ????? ?????? ???????? ?????????????? (ASCVD) ???? 24 ?????? ?? ???????.

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4. ?????? ????? ?????? ??????? ???????

?????????? ??????? ??????? ???????? ?? HMB-Ca ?????? ???? ?? ??? ?????? ???????:

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????? ???? ??????: ?????? ????? ????? ????? ??????, ????? ?? 6 ??? ?? HMB-Ca ???? 3 ???? ???? ?????? ????? ???? ?? ?????? ???????? ??? ??????? ???? ?????? ?? 2.3 ????? ?? ??? ?????? ?-2.5 ????.

???? ???? ???? ??????: ???? ????? ??? ??? ????? HMB-Ca ???? ??????? ?????? ????? ?????? ???? ??????? ????? ?? ?????? ???? ???????? ?-41% ????? ?? ?????? ???? ?-57%.

????? ??????? ???????: ????? ?? HMB-Ca (50 ?"?/?"?/???) ???????? ????? ?????? ?? ???? ???? ?-24% ??? ???? ??????-???????? ?-19%.

???? ??????? ??????? ?? ??? ???? ?? HMB-Ca ?????? ????? ???? ?? ??????? ???? ?????? ????? ?????, ?????? ?? ?????? ?-6 ???????? ?? ??????, ???? ??????? ????? ????? ???????? ???????? ????? ????? ??????? ?????? 8. ?????????? ??????????? ?????? ????? ?? HMB-Ca ?????? ???? ????? ?????? ?? ??? ?????? ???? ?-91% ?????? ?? ???? ??????? ?? ????? ?????? ??? ?-±7%.

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5. ????? ????? ????? ?????????

???? ????? ????? ?????? ???????, ?????? ?? HMB-Ca ?????? ????? ????? ??????:

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????? ??????? ?????: ?????? ?? ????? ???? ?????, ?????? ?? HMB-Ca ?????? ????? ?????????? ????? ?? ??? ???? ?? ????? ??????? ?????? ?-17% ??? ???? ?-ADL ?-23% ???? 6 ??????.

????? ?????? ????????: ???? ????? ????? ????? ?????, ???? HMB-Ca, ???? ????? ???? ????? ???? ???? ?-58%, ???? ??????? ?????? 3-4 ?????? ????? ????.

?????? ????? ???: ??????????? ????? ???? ??????????, ????? 3 ??? ?? HMB-Ca ??? ???, ?????? ?? ????? ??????? ??????-????? ?-72% ??? ??? ????? ?????? ???? ?-39%.

????? ????? ???? ?????? ?????, ???? ????? ?????? ?? HMB-Ca ????? ?? ??? ???????? ????? ?-44% ??? ??? ???? ??????? ???????? ?-51% ???? ?????? ?????? ???????????. ?????? ?????? ?????? ????? ????? ?? ????? ?????? ????? HMB-Ca ??????? ???? ????? ??????? ????? ????? ?????? ?? ?????? ?????? ????? ?-37%.

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6. ???? ?????: ????? ??????? ????????????

?????? ???-????? ?? HMB-Ca ????? ???????? ?????????? ?????:

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????? ???-?????: ???? ?????? ?? HMB-Ca ????? ???????? ?????? ?? ???????? ????? ????? ?? 3.7 ???? ??????? ????? ?-72 ????.

???? ????????? ???????: ???? HMB-Ca ???? ?-62%, ???? ?-HMB-CA ???? ???? ?? 99.9% ???? ??????.

??????? ??????? ????????: ????? ???? HMB-Ca ?????? ????? ??????? ?????? ????, ?????? ????? ????? ?? ????? ?????? ????? ?-EMG ???? ???.

?????? ??? ?????? ???? ??????? ????? ?? ????? ?????? ?? HMB, ?????? ??? ?? ?????? HMB ?????? CRISPR-Cas9 ???? ?????? ????? ?? 29% ???? ???? ????? ????. ????? ????-????? ?????? ????? ????? HMB-Ca ???? ???? ?????? ??????, ???????? ????????? ??? ????? ?? 2.8 ??? ?? ????? ????? ????????.

???? ?????? ??????

????? ?-HMB-Ca ???? ???????? ????? ?????, ????? ?? ?????:

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???? ?????: ????? ?????? ????? ???? ??? ????? ?-5 ??? ????, ????? ????? ???? ????? ??? ????? ?????? ??????.

???????????? ?????: ????? ????? ?? ?????? ?? ??????? 2-3 ?????, ?????? ???? ??? ????? ?????? ?????? ?? ??????? ???????.

??????? ???: ????? ???? ?? ????? ????? ???? ????? ?????? ????? mTOR.

???? ?????? ?????? ?? ?????? ?????????? ?????? ????? (ISSN) ???? ?? ????? ?? HMB-Ca ???? 2-3 ?????? ????? ?????? ??????????, ????? ?????? ?? ????? ??????? ?-1-2 ???/???. ?? ??????? ????? ????? ???????, HMB-Ca ????? ????? ????? ????? ?????????? ??????? ??-?????, ??????? ???? ??? ????? ???????.