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    2024-08-28

    ????? ???????? ???? ??? ????? ???? ?? ?????? ??????, ???? ???? ?????? ????? ?????? ?? ????? ????? ?? ???? ????, ?????, ???? ??? ????? ?? ?????? ????? ????? ?? ??????? ????????? ????, ????? ??????? ????????, ????? ?? ????? ????? ??????? ?? ????????, ??? ??? ?? ????? ????????.
    ??? ????????, ??? ????? ??????, ???? ?????? ?? ????? ????? ??? ????? ????? ????? ?? ???? ???? ???? ?????, ???????, ????? ????? ???????. ???? ???, ???? ???????? ????? ????, ??? ?? ????? ?????? ??????, ?? ?????? ??????? ?? ???? ??????? ??????? ??????? ??????? ????? ??? ???? ??????? ?????, ??? ????? ????? ??? ????????? ????? ?????? ???.

    ?????, spermidine (SPD) ???? ????? ???? ?? ???????? ??????, ???? ????'??? ??????? ?????? ?? ????? ?? ???? ?? ???????????????? ?? ??? ?????.

    ?-8 ??????? 2024, ?????? ??????????? ???? ????????, ???????? ????? ???????????? ????? ????? ????? ???? ??? "???????? ????? ????????? ?????? ???" ???? ??? Nature Cell Biology ??????? ????.

    ?????? ???? ?? spermidine ????? ???? ???????? ??????? ???? ?????? ???? ????, ??? ?????? ????? ????? ??????? ??????? ?? ??? ??? ????? ????? ???? ????? ?????? eIF5A-hypusination ???? spermidine ????????? ????????? ?? ????????.

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    ??? ??????, ?????? ??????? ???? ???? ????????? ??????? ??????? ?? ??????? ??????? ???????? ?? ???????, ??? ?? ??? ?????? ???????? ?????? ?????.

    ????? ?? ???????? ???? ?????? ???? ?? ????? ???????? ???????. ????? ??????? ???????? ????? ???????? ?? ?????? ???????? ???? ????? ?????? ?? ???? ??, ????? ????????, ????? ???????? ?????? ????????, ?????? ????, ?????? ??????, ????? ??? ????? ???????? ??????. ????? ???, ????? ???????? ???? ?????? ???? ?????? ???? ??????? ???? ????? ????? ????, ???? ????? ????? ???????.

    ????? ?????????? ????????, ?????? ????????? spermidine ???? ?? ???? ???? ???? ?????, ???????, ????? ????? ??????? ??? ???????? ????? ?????? ????? ????? ????? ???? ????????. ?????, spermidine ???? ?????? ?? ??? ????????? ??????????? ?????? ??? ??? ??????, ?? ????? ???? ??? ?? ?????? ?????? ?????? ?? spermidine ?????? ????? ?????? ?????? ?????? ???? ???.

    ???????? ??? ??? ?? ???????? ???? ????? ???????????. ????? ????????, ???? ????? ?????? ???? ?????????? ?????? ???? ????'??? ?????? ??????.

    ?????, ???, ????? ?????? ????????? ??????? ?? ????? ????? ?? ???? ???? ???????? ???? ???? ????? ????????, ???? ???????? ???? ?????. ????? ?????? ???, ???? ????? ??? ??? ??? ??????? ?????? ?????????? ?? ??? ???????? ?????? ?? ?????? ?-spermidine.

    ????? ??? ?? ???? spermidine ??? ??????, ????? ?????, ?????? ???? ??? ??? ????? ??? ?? ????? ?????? ?????. ???? ?? ?????? ??????? ?????? spermidine ???????? ??????? ???????? ?????? ??? ???? ??????, ??????? ?????? ???????.

    ?????, ??????? ?????? ????????? ???? ????? ???? ?? ??????? ???????? ?? ??? ?? ?????? ???? ????? ??????, ??? ?? ?? ??????? ?????? ?? ??? ?? ??? ??????? ?????? ???? ?????.

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    ?????? ?????, spermidine ????? ?? ??????? ???? ?? ??? ????? ???????? ??????????? ?? ???? ????? ????? ???????? eIF5A. ??? ?????????-?????????? ??? ???? ???????? ?????? ???? ???????? ?????? ???????? ?????? ????? ???? ?????? ????.

    ??? ???, ????? ????? ?? ?? ??????? ?? ??? ?? ?????? ???? ?????? ???? ????? ?????? ?????? ???? ????? ?????? eIF5A-hypusination ???? spermidine ????????? ????????? ?? ????????.