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    2025-02-15

    ????????? (Cysteamine,CS), ????? ?? ??? β-merhydrylethylamine, ???? ?????? ????, ????? ???? 99 ~ 100 ℃, ??? ???, ???? ???? ????????, ????? ??????. ?????? ???? ???? ?????? sulfhydryl ?????? ??????, ?? ?? ????? ???????? ?????????. ??? ???? ???? ???????? ????? ???? ??? ?? ?????? ??????????? ??????. ???????? ???????? ?? ????, ????? ????? ?? ?????? ????????? ????? ?????? ??????? ???????????? ??? (CysteamineHydrochloride, CSH) ?????? ??. ??????? ??????? ?? CSH ??????, ?????? ????????? ????, ???????????? ????, ????? ?? ?????????? ??????, ????? ???? ?? 70.2 ~ 70.7 ℃.

    CS ????????????? ??? (CSH) ?? ?????? ?????? ?????? ???????? ???????, ??? ?? ???? ?????? ????? ????, ????? ?????? ??? ?????? ????? ???????? ????? ?????? ????.

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    ?????? ?? ????? ????, CSH ????? ???? ??? ?-CA (cysteamine hydrochloride).

    ??? ?-logP ????? ?-cysteamine hydrochloride (CA) ??? ???????? ????? ???? ??????? ?? ??????? ??????????? ???? ????? (??????/???????????).

    ???????? ??????????? (CA) ?????? ???? ???? ?????????? ????, ??? ???? ?? ???? ?????????? ?????, ?????? ?????? ???????? ????? ?????????, ????? ???? ??, ???? ?????? ?? ????? ?????, ????? ??? ?????? ?? ??? ???? ????? ??? ????? ???? ?? ??? ????? ???? ????? ??? ????. ??????? ??? ??? ???? ???? ???? ????, ??? ??? ?????, ??? ????? ?????? ?? ????. ???? ???? ???? ?? ????, ??? ??????? ????? ???? ?-CA ???? ????? ????? ???? (?????? ????? ?-alcalic low ??????? ????), ???? ????? ????? ?????? ???, ?? ???? ????? ???? ????, ?? ?????? ???? ?? ????? ????!

    ????? ?????? ?? ???????? ??????????? (CA) ????? ??? ?? ????? ???????????, ???? ??? ???? ???? ????? ??? ???? ?????? ?????. ??????? ????? PH ???? ?????? ???? ?? ????? ???????????, ?????? ????? ????? ?? ????? ????? ?????? cysteamine hydrochloride (CA) ??? ???? ???? ???? ???? ???? ??? ??, ????? ?????? ?? 5 ???? ?? ????? cysteamine hydrochloride ?????? ???? ???? ???? ?????? ?? ????? ?????? ??????????? ???? 15 ????.

    ???????? ??????????? ??? ?????? ??-??????? ???? ?????? ?????? ?????? ?????? ????? ??????? ????, ????? ????? ???? ????????????? ?? ????? ????. ?? ?? ???????? ??? ??? ??????? ????? ?????, ???? ????? ???? ???? ???? ?? ?????? ?? ?????, ????? ?? ???? ?????, ??? ????? ?? ????? ?? ?????.

    ????? ???????? ??????????? ?????? ?? ?????, ?????? ?????? ??? ???? ???? ???? ???, ??????? ?? ????? ????? ???? ???? ???? ????, ????? ?? ???? ?????. ??????? ?????? ???? ???, ?????? ??? ??? ??? ??? ?? ??? ???? ?????, ?????? ?????? ??? ????? ?????? ????? ???.