????? ?????? ???? ????? ???? ???? ?????? ????? ?? ????? ?????? ??????? ???????, ??? ????, ?????? ?????? ??????? ?????, ??? ?? ?????? ???????, ?????? ???? ?????? ???????? ?????. ????? ???? ??? ???, ???? ????? ????? (????? ?????), ????? ?? ??? ????? ????? ??? ???? ?? ?????? ???????? ??????? ?????. ????? ????? ????? ???? ????? ???????, ???? ??? ?????? ?????? ??????. ?? ?? ??????? ????????? ??? ???? ??????? ???????? ?? ???? ??? ????? ??????? ?? ???????? ?????? ????? ?????? ?? ??? ???? ??? ????? ????? ???, ?????? ????? ???? ?? ?????? ???????.

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???????? ??? ??? ??????? ?????? ???????? ???? ???? ?????? ?? ?????????????? 5-hydroxytryptophan (5-HT, ?????? ?? ????????) ????. ???? ?? ?? ?????? ???? ??????? ?????? ??????? ?? ???????? ?????? ??? ???? ?????? ????? ???, ??? ??????, ????, ?????????? ??????. ??????, ???????? ????????? ??? 5-HT ??????? ?? ??????? ??????? ????? ???????. ?? ????? ??? ???????, ??? ????? ??????? ?? ???????? ?????? ??? ????? ?? ???? ???????? ????? ????? ?????? ?? ??? ???? ?? ?????? ???? ??????, ??????? ???? ???? ?? ??????? ???????.

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?????, ??????? ?????? ??????? ??? ???? ???? ????? ????? ?????? ?? ??? ??? ????? (CMS). ?? ?????? ?? ??????? ?????? ?? ????? ???? ?????? ????? ???, ??? ??? ????, ????? ?????? ???????? ??? ????, ???? 21 ???? ?????? ??? ????? ????? ??? ??????? ???????? ????? ????????. ??????? ???? ?? ???? 21 ???? ?? ??? ?????, ??????? ?????? ???? ???????? ???????? ????? ??????. ?????? ???? ????? (OFT), ???? ?? ????? ????? CMS ?????? ????? ?????? ?? ???? ????? ????? ????????, ?? ????? ?? ?? ???? ????? ???? ????. ?????? ????? ???? (TST), ??? ????? ?? ?????? ?????? CMS ????? ????????, ?? ????? ?? ????? ???? ????? ??????. ??????, ????? ????? ?? ?????? ?????? CMS ???? ????? ???????, ?? ????? ??? ????? ???????, ?? ?????? ?? ????? ??????? ?????? ??????? ????.

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???? ???, ??????? ????? ????? ???????? ????? ?? ?????? ??????? ?? ???????? ????? ??????. ??????? ???? ?????? ????????? ????? ?? ?????? ?????? CMS ???? ????? ???????, ???? ??????????? ????? ???? 5-hydroxytryptamine (5-HT) ????? kynurenine ???? ????? ???????. ????? ???? ???? ?????? ?-mRNA ?? tph1, ????? ???? ??????? ?? 5-hydroxytryptamine, ??? ????? ???????? ????? ???? ??? ?? ?????? ?????? CMS, ??? ????? ?? 5-HT ???? ??? ???? ???? ?????. ?? ????? ?? ?? ???? ????? ???? ?? ??????????? ?? ?????? ??????? ????????-5-HT ?????? ?????? ?? ??????, ??????? ??? ???? ????? ?? ???? 5-HT ???????.

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????? ????????? ???? ???? ????? ?????? ?? ????? ???-???, ???????? ??? 5-HT ???? ????? ???? ?????? ???? ?????? ?????? ??????? ?????? ??????? ??????? ??????????? ???? ???? ??? ???, ???????? ??????. ??????? ????? ??? ??????? ?????? ?? ???? ???????????? ??????? 5-HT ???????? ??????? ??????? ??????????. ??????? ???? ????? ????? ???? ????? ??????? ?? ?????? ?? ???????????? ?????? ?????? ???? AgRP ?-OX1R, ???? ?????? ?? ?????? ?? ?????? ????? ?????? ??? LEPR, MC4R ?-5-HT1B. ?? ????? ?? ?? ??????? ?????? ????????-5-HT ????? ?????? ???????? ????? ????? ?? ??? ????? ?? ????? ????? ??????????.

?

??, ??? ????? ?? ???????? ????? ???? ?? ??? ??? ????? ????? ?? ??? ??? ??? ?????? ???????? ?????? ??? ???? ???????? (100 ?"?/?"? ?- 300 ?"?/?"?) ????? ?????? CMS ??????? ??? ??? ???? ???? 21 ????. ??????? ???? ?? ???? 21 ???? ?? ??????? ?? ????? ???? ?? ???????? (300 ?"?/?"?), ????? ????????? ????? ??????? ?? ?????? ?????? ??? ???? ??????? ???? ??? ?????? ????? ???????, ?????? ???? ?????? ?????? ?? ????? ?????. ?????? ?????? ???? ???????? ???????? ?????? ???? ????? ???? ?? ??????? ?? ?????? ?????? ?????? ???? AgRP ?-OX1R ?????????? ??????? ?? ??? ??? ?????, ??? ????? ?????? ?? ?????? ????? ?????? ???? LEPR, MC4R, 5-HT1B ?-5-HT2C. ???? ????? ?????? ??????? ????? ?? ???????? (100 ?"?/?"?) ?? ???? ????? ??????? ?????? ??????????, ????? ???? ?? ??????? ?????? ????? ????? ??????? ?????????? ???? ??????????.

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?????? ?????? ??????? ???????? ???? ?-5-HT, ?? ??? ????? ?????? 5-HT1B ?-5-HT2C ?? ????????? POMC, AgRP ????????? ?????, ???? ?? ??????? AgRP/NPY ???????? ??????, ????? ??????? POMC ??????? ?????? ??????? ????? ??????, ????? ??? ???? ????? ??????? ???????. ?? ???? ????? ??????? ???????? ???? ?????? ????? ????? ?? ??? ????? ????????-5-HT.

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??????? ?????? ?? ??? ??? ??????? ????????? ?? ????? GT1-7 ??? ???? ??? ???? ?? ?????? ?????????? ?? 5-HT ?? ???????????? ??????? ???????. ?? ????? ???? GT1-7 ?? 10μM ?? ???????????? (CORT) ???? 24 ???? ??? ????? ???? ??? ???????. ??????? ???? ??????? ?? ???? ?????? ?????? ??? AgRP ?-OX1R ??? ????? ???????? ?? ??? ????? CORT, ???? ??????? ?? ???? ????? ?????? ??? MC4R, 5-HT1B ?-5-HT2C ??? ????? ????. ???? ????? ????? ?? 0.1μM 5-HT ???? ??????, ???? ??? ????? ????? ??????? ?? ?????? ????? ?? AgRP ?????? ?? ??? CORt ????? ?????, ??????? ?? ?????? ?? MC4R, 5-HT1B ?-5-HT2C. ?? ???? ??? ???? ?? ?????? ?????????? ?????? ?? 5-HT ?? ???????? ?????????.

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????? ??????:

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?????? ?? ??? ????? ?? ?????????? ?? ???????? ???????? ???????: ??? ????? ??? ?????? ????? ????????? ????? (P

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????? ???????? ?? ?????? ???????? ????? ?????? ?????? ?? ??? ??? ?????: ????? ???????? ?????? ???? ?????? ??????? ????? ????? ?????? ????? ?????? ?? ??? ??? ????? (P

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?????? ?? ????? ???????? ?? ???????? ????? ?????????? ??????? ?????? ?????? ??? ?????: ????? ???????????????? ????? ??????? ?? c-fos ?-AgRP ????? ARC ?? ?????????? ?????? ??? ????? ??? ????? ???????, ???? ??????? ?? LEPR ??? ????? ??????? (P

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?????? ?? ???????? ?? ?????? ??????? ?? 5-HT ?????????? ?? ????? ??? ?????: ???? ???????? ?-5-HT ????? ??? ???????? ???? ????? ???????? (P

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??? ???, ???? ?? ???? ?? ??? ????? ???? ?????? ???? ????? ??????? ?????????? ?? ??? ????? ?????? ??????? ????????-5-HT, ??? ????? ????? ????? ?????. ????? ?? ???????? ???????, ?????? ???????? ?????? (300 ?"?/?"?), ?????? ???? ??????? ?? 5-HT, ?????? ?????? 5-HT1B ?-5-HT2C ??????????, ????? ???????? AgRP/NPY, ?????? ???????? POMC ?????? ?????? ??? ??? ??????? ???? ?????????? ????? ??????.

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?????? ?????? ?? ?? ?????? ????? ?????. ????? ??????? ?? ?????, ????? ???? ???????? ?? ????? ?????? ??????? ?? ??? ??? ??????? ????. ?????? ???? ???? ???? ???? ???? ?????? ???? ????????? ????, ??????? 5-hydroxytryptamine ??????, ????? ??? ?????? ????? ?? ?????? ????????????????, ???????? ???????, ???? ?????? ??????? ?????, ??? ?? ?????? ???, ????? ??? ?????? ???????? ?????. ???? ?? ???? ?? ?????? ?????? ?? ???????? ????????? ??? 5-hydroxytryptophan ???? ????? ???-???-??????, ????? ??????? ?????? ????? ????? ??? ?????? ?????? ??? ??? ??????? ????.

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?????? ?? ???????, ??????? ?????? ??? ?????? ???????? ?????? ?????? ??????? ??? ???? ?? ???. ???? ??, ????? ????? ?? ?????? ?????? ????????? ?????? ?????, ??? ?????, ?????, ??????, ?????, ?????? ???? ????, ????? ????? ?????? ??? ????????? ????, ???? ?? ??????? ?? 5-????????????????, ???? ???? ?? ???? ????? ?????? ????? ???. ?? ???, ?? ????? ?? ???????? ????? ???? ???? ?????? ?-100%. ??????, ????? ?????? ???? ????? ???? ?? ???????? (???? ???? ?-500 ?"?/?"?) ????? ????? ???? ??????. ???, ????? ?????? ?????, ????? ????? ?? ???????? ????? ?????, ?? ????? ????? ????? ?????? ????????.

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?????, ?????? ?????? ????? ??? ????, ?????, ???? ???' ????? ?? ??? ????? ?????? ??? ?????? ????????? ?????????? ????, ???? ?? ????? ????? ?? ??? ????. ???? ?????, ????? ???? ?????? ????????? ?????? ???? ????? ????? ????? ?? ???? ????? ?????? ????????? ?? ???. ???? ???????? ?? ????? ?????? ?????? ??? ?????? ?????, ?? ???? ????? ???? ?????? ????????? ??????.

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??????, ???? ?? ???? ?? ?????? ?????? ?????? ?????? ?? ??? ??? ????? ?????? ???? ?? ???????? ????????, ????? ????????? ???? ????? ???, ????? ?????? ??? ??? ??????? ????. ????? ??????? ????? ???????? ?????? ??? ????? ?? ?????? ???? ???? ?? ????? ???????? ??????, ??????? ?? ???? ?? ????? ??? ??????? ????? ?????? ?????? ?????? ?????? ??????? ????? ??????. ??? ??????? ???????? ????? ??????, ?????? ?????? ?????, ???? ???? ????????? ????? ??????, ???? ??????? ????? ????? ???? ???? ????? ????? ???? ??? ????.