???? ??? ????????? (ALD), ???? ???? ??? ?????? ?? ??? ????? ????? ????? ???, ??? ??? ?????? ???? ??????? ????, ???? ??? ????? ????????, ??????? ????????, ???????? ??? ???????? ????? ???????. ????? ????????, ??????? ?? ???? ??? ????????? ????? ???? ????? ????.

?-2 ????? 2024, Liu Zhihua ??????????? Tsinghua, Wang Hua ??????????? Anhui Medical, Yin Shi ??????????? ???? ??????????? ?? ??? ??????? ????? ????? ???? ??????? "????? ???????? ????? ?? ????? ????????? ???? ???????" ???? ??? Cell Host & Microbe "Bacteroides acidifaciens and detoxentification ammonia".

???? ?? ????? ????? ?????? ???????? ?????? ?????? ?? ???? ?? B. accidifaciens ??????? ?????? ??? ??????? ?? ??? ??????? ???????.

?? ???????, B.accifaciens ????? ?? ????? ??????? ?? ?????? ??? ??????? ????? ????????? ?? ??? ??? (BSH). ?????? ?????? ???? ?????-????? ?????? ?? ????? ?-FXR-FGF15 ????, ???? ?? ????? ????? ????, ????? ?? ?????? ?? ornithine aminotransferase (OAT) ??????????, ???? ?????? ?? ????? ??????? ?? ???????? ?????? ???? ???????. ???? ????? ??? ?????? ????? ???? ??????? ?? ???? ???? ????.

????? ??, ??????? ???? ??????? ????? ??? ????????? ????? ?? ???? ?????? ?? ??????? ?? ????? ???????? ?? ???? ??? ????????? ??????? ?? ??? ????? ????? ?????? ????? ?????? ????.

??????? ???? ?????? ????? ???????? ?????? ????? ???????? ?? ???? ???? ?????????? ???????, ???? ???? ?? ???????? ???? ?????? ????? ?????? ????? ?? ??????????? ????, ???? ?????? ???????? ???? ?????? ?? ????? ????? ????????.

?????? ?????? ???????? ?????? ?????? ????? ??????? ?? ??????????? ?? ??????, ??????? ????? ??? ???? ??? ???? ????? ?? ?????? ????? ???? ?????????? ??????????? ?? ?????? ??????? ??????? ????? ??????????.

???? ??????, ???? ?? ????? ??????????? ?? ?????? ??????? ?????? ???????? ?????? ?????? ?? ???? ????? ????? ????????????? (ALT) ??????? ????????????? (AST), ??? ????? ???? ???????? ????? ????, ?? ?????? ?? ?? ?????? ???????? ?????? ?????? ?????? ?? ??????? ?-ALD ?? ??? ????? ???? ?? ???? ??????????? ?? ????.

????? ???? ?? ????? ???????? ?????? ????? ??? ??? ???, ???????? ???? ????? ????? ????? ?? ???? ??? ?????????, ??? ?????? ?? ??? ??????? ??? ???? ??????, ??? ????? ?????? ????? ?? ????? ???????? ?????? ?????? ?????? ????? ??? ?????????.

???? ????? ????? ??? ????? ???????? ????? 25-30 ??? ?? ???? ?? ????? ???????? ????, ?? ??? ?????? ???? ?????? ??????? ?????????. ????? ?????, ????? ?????? ?? ?????? ?????? ?????? ???????? ??????? ???? ?????-?????????? ??????? ?????.

??????, ??????? ??????? ?? ?? ?????? ????? ?????? ???????? ?????? ????? ???? ?? ????? ???? ?????? ?? ??? ??????? ????? ?????? ??? ???? ?? ????? ????? ????. ????? ?? ?? ??? ????? ??????? ?????? ??????.

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