???????? ???? ????? ?????? ??????? ???? ???? ????? ???? ???? ????. ?? ??? ????? ???, ??????? ??? ????? ???? ??????? ????? ?????. ??? ??? ?????? ?????? ?? ??? ?-FDA ???? 1998. ???? ?????? ?? ?????? ????????? ??? ???????, ????? ????? ?? ????? ??????? ???. ?? ???? ?????? ?? ??? ???? ?????. ?????, ???????? ???? ????? ?? ??? ?????? ???? ?????? ???? ???? ?????? ?? ???? ?????? ??????? ?? ??? ?????? ??? ??? ??????? ??? ????????? ?? ??? ???????, ?????? ???? ????? ???? ????. ?????? ????? ???? ???? ???????? ???? ?????? ????? ???? ???????? ?????? ?? ??? ???? ????? ?????? ???? ???. ??????? ????? ???? ?????? ?? ??????? ??????? ?????? ???? ????????? ??? ?????? ???? ?????? ?? ?????? ????. ???? ?????? ????? ?????? ?????? ????, ?-FDA ???????? ???? ?? ????? ????? ????? GRAS (??????).

??????? ???? ?????? ???? ????? ?-400 ???? ????, ???? ?????? ??????, ?????? ??????, ?????? ??????????, ??????? ?? ????? ??????, ???? ?????? ??????, ?????, ?????, ?????, ????? ???, ???? ???? ???????? ?????????. ?????? ??? ??????? ?? ???? ????? ????? ?? ??????? ?????????, ?? 87 ?????? ?????? ?????? ????? ????. ???? ???? ??????? ????? ??????? ?????? ??? ??????? ???????? ???????? ??????, ?????? ?? ????? ?? ????? ??? ?????. ?? ??? ??? ????? ???? ?? ?????? ???????? ????.