???? ???????? (PC), ??? ????? ????? ??????? ????? ??????, ??? ??? ???? ???, ???? ??? ?????? ????? ??????? ?????? ??? ?? ????? ??????? ?????? ????? ?? ??? ????? ???? ????. ???? ??, ???? ???????? ???? ????? ????? ???? ?? ??? ?? ??? ???????? ?????? ??????? ???? ?????? ????.

??? ?????, ?????? ???? ?"???? ?????? ?????, ??? ?????? ??????", ?"??????" ??? ??????? ???? ?????? ?????. ???? ???????? ??? ???? ?????? ????? ????. ?? ???? ???? ????? ??????? ???????, ???? ???? ???? ?????? ??????, ???? ????? ?? ?????, ???? ???? ????? ???? ?? ??????? ???? ???????? ????? ?? ????????? ?? ??????.

?-25 ???????? 2024, ???? ??????? ???? ?????? ?????? Cold Spring Harbor ???? ???? ??? ?????? ????????? ?????? Science ???: Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function paper paper.

?????? ???? ?? ???? ???-????????, ?????? (?????? K3), ???? ???? ?? ??????? ???? ????????. ?????? ??? ???? ???? ???? ?? ?????? K, ????? ???? ??? ?????? ???? ??????, ??????? ?????????? ??? ????? ???? ????? ?? ??????? ????????? ????.

????? ?????? ???? ?? VPS34 ??? ??? ????? ?? phosphatidylinositol 3-kinase (PI3K), menadione ???? ???? ?? ??????? ?? VPS34, ?????? ?? ?????? ?? PI3P ??????? ?? ???? ??????? ?????? ????? ?? ??? ???? ????????. ????? ???, ???? ???????? ????? ??? ???? ?? ??? ????? ?????? ??????? ??? ????? ???? ??. ?????, ???? ????? ????? ?? ??????? ?? ????? ??????? ?? ?????? ????? ?????? ??? X-linked myotubulin myopathy (XLMTM).

?????? ??? ?????? ??? ????? ?? ????? ?????? ????? ??? ??? ?????? ????? ?????? ?????? ?????? ????? ??????? ?????? ????? ????? ?? ?????? ?????.

????? ???? ????? ????? RapidCaP ?? ???? ???-????????, ?????? ???? ?????? (MSB), ?????? ?????? ???? ?????? ??????? K. ?? ???? ?????? ????? ?? MSB ??? ?????? ????? ???? ?? ??????? ???? ???????? ?????? ???? ???? ?????.

??? ???, ?????, ?????? ?-Science, ???? ?????? ????? ???? ???-?????????? ?????? ??? ?????? ?? MSB ????? ????? ???? ?? ??????? ????? ?? ???? ????????. ????? ??? ??? ?-MSB ???? ???? ?? ??????? ?? PI3K ????? VPS34, ?????? ?? ?????? ?? PI3P ??????? ??? ???????, ?? ?????? ????? ?? ??? ???? ????????. ?????, ?-X-linked myotubular myopathy (XLMTM), MSB ???? ???? ?????? ????? ?? VPS34, ??????? ?? PI3P ????? ??????? ???? ?? ??????? ???????.