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    2025-03-13

    2. ???? (?? D-Mannose) ??? ???? ????, ?? ?????? ???????, ???? ???? ???? ????? ???? ???? ??????, ?-90% ?????? ????? ?????? ??? ???? ???? ?-30 ?? 60 ???? ???? ??????, ?? ??????? ???????, ???? ???? ????? ?? ??? ????? ???, ??? ??? ????? ???? ????. ???? ???? ?????? ?????? ??????? ?? ??????, ???? ?? ????? ?????, ????? ?? ????? ?????? ??????? ??????? ??????. ???? ????? ?? ?????? ?????? ?? ???? ?????? ?????? ?????? ??? ????? ?????? ?????? ?????? ???.
      ????? ???????? ????? ?????? ???? ?? ????. ???? ???? ????? ??? ????? ?? ????? ????? ?? ?????? ????? ????? ????. ???? ????? ???? ??? ???? ?????? ?????? ?????? ??? ???? ???? ????? ????, ????? ?????, ??????, ??????? ??????, ?????? ???', ?? ???? ????? ???? ????? ???? ??? ?? ??? ??????? ?????? ???????. ??? ?????? ?????? ??? ????? ?????, ????? ?? ????? ???? ???? ?????? ????? ???? ???? ??????. ?????? ????? ?????? ?? ????? ?? 50 ???? ???? ???? ????? ???? ????? ?????, ???? ???? ???? ???????? ?????? ??? ???.
      ??? ???? ?-80, ???? ???? ?? ????? ?????? ???????????? ?????? ?????? ????? ????. ????? ????????, ?? ????? ??????? ???? ???????? ?? ??????? ????????? ???????? ?? ????, ?????? ?? ???? ?????? ????? ????? ???? ??? ?????? ?? ????? ??? ?? ?????? ???????.
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      ???? ????? ??? ??????, ??????? ?????? ???????, ????? ????? ?? ??? ????? ??????? ???????? ?????? ?????? ?????, ?? ????? ?? ???????? ?? ??????? ?????? ???????? ?????? ????? ????? ????, ????? ?? ????? ?? ????? ??????, ???????? ????? ?????? ?????? ?????? ???? ?? ???? ???? ???? ????? ????. ??? ?????? ????? ???? ?????? ?? ??? Escherichia coli ?????????? (UPEC). UPEC ???? ?????? ?? ??? ??? ????? ??????? ?????? ??????? ????? FimH ????? ???? ????? ????. ?? ???? ???? ??? ????? ?????? (M4284). ????? ??? ?????? FimH ????? ?? 100,000 ??? ?? ????, ?? ??? ???? ???? ???? ???? ?? ??????? ?????? ????? ?????? ?? E. coli ????.
      ????? ???????? ???? 2016, ????? ????? ???? ???? 13 ???? ??? ????? ???????? ???????? ?????? ??????? ?????? ????? ??? ??????? ?? ??? ???????. ??? ????? ????? ?????? ????? ????, ??????? ????? ?? ?????? ???? ??????, ????? ???????? ?????? ???? ????, ?????? ??????? ?? ??? ???. ?????? ?? ????? ??????, ?? 4.5 ???? ???????? ???? ???? ??????, ????? 33.3 ???? ?????? ???????. ??????? ????? ?????? ?? ???? ???? ????? ?????? ?????? ?????? ????? ???? ????? ????? ?????? ?????? ?? ????? ????? ????.