????? ??????, ?????? ??????? B13 (????? ??????) ?????????? ??? ???? ????, ??? ????? ????? ????? ??? ???? ?????, ?????? ???, ???? ?????, ???????? ????? ??????? ?? ????? ????. ???? ????"? ????? ??????? ?????????? ???????? ?? ????? ???????, ???? ?? ????? ????? ?????, ?????? ????? ?? ?????, ???????? ??????? ???????? ????? ?? ????? ??????? ?? 5 - amino- imidazole-4 - A ?-90 ????? ?????? ??? ?????, ??? ?? ????? ?? ?????? -???? ???? (????????? ?? ????? ?? ?????? ????????? ???), ??????? ????? ?????? ??????? ?? 5 - ?????. ?????? ????? ?????? hematopoietic, ??? ??? ?????? ?????? ??? ???"? ?????? ??????? ????? ?? purine ????? ?????? ??????? ????? ?? ???? ????? ???; ??? ?????? ?? ????? ??????? ?? ??? ?????? ?? ?? ????? ????????. ?????? ????? ?? ????? ?? ??????? ?????, ?????? ??????, ??? ????? ?? ??????, in vivo ??????? ?????? ???????? ?????? ?????? ??. ????? ????? ???????? ????? ??????? ?????? ??????? ?? ?????? ?????, ????? ????? ??? ????? ?????? ?? ?????, ???? ?????????? ?? ??????? ???????? ??????? ?? ?????? ????? ????, ????? ??? ?? ????? ???? ?????? ?????? ????? ???? ?????? ???????, ???? ?????? ?????? ??????? ???????? ?? ???? ????, ??? ???? ?? ???????? ???????.