Ko te SAIB(sucrose isobutyrate acetate) he rongoa mo nga mahi maha. He wai kakao kua whakaritea ma te whakakaha o te huka maori (sucrose) me te waikawa acetic me te anhydride isobutyric. He ranunga i hangaia ma te whakamaarama me te hanga tino parakore. Ka taea te whakamahi hei rauemi apiha tuku toimau, whakarewa/kawe me te aukati i te tukino tarukino.

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Ko nga ahuatanga hua SAIB

Ko te SAIB he whakarewa pai / kawe mo te API hydrophobic me te mahi tuku puhoi.

E kore te SAIB e whakatioataia, ka noho amorphous i te pāmahana rūma, e tino whakatairanga ana i te tere o te tuku tarukino;

Ko te SAIB ehara i te polymeric, a, karekau e whakakorikori, e heke ranei ina pa ana ki nga wai o te tinana. He wairewa te SAIB i roto i te maha o nga whakarewa pararopi me te hototahi ki nga rawa maha; Ka taea te marara te SAIB ki te wai ma te awhina o nga whakarewa pararopi.

Kei a SAIB nga ahuatanga koiora ka taea te whakamahi mo nga tono papaki whakawhiti, reo-a-waha me te papaki.

Tono hua

1. Whakaroa te tuku

I te ahua i runga ake nei, ka kitea he uara HLB te SAIB mo te 5 pea, e tohu ana he hydrophobic.

2. He pai te wairewa API otinga

Ko te SAIB Hydrophobic he whakarewa pai / kawe mo te API me te ngoikore o te wai, a, ko te whakamahinga o te SAIB ka whakapai ake i te whakarewatanga o nga raau taero korekore.

3. Aukati i te whakamahi tarukino

Ko te whakamahinga o te SAIB ka whakanui ake te rahi o te matūriki o te opioids i te wa e huri ana, ka whakararu i te tangohanga tarukino.

(1) Ko nga polymers (polyoxyethylene me/ranei hydroxypropyl methylcellulose) me te tocopherol acetate he kirikiri i hangaia mai i te otinga waipiro o SAIB. Ka whakarōpūtia nga takahanga ki te kore i rongoa / kare i rongoa, i rongoa wera ranei / i rongoa (i rongoatia i te 90oC mo te 30 meneti).

(2) Pseudoephedrine hydrochloride, polymers (polyoxyethylene me/ranei hydroxypropyl methylcellulose) me te tocopherol acetate he kirikiri i hangaia mai i te otinga waipiro o SAIB. Ka whakarōpūtia nga takahanga ki te kore i rongoa / kare i rongoa, i rongoa wera ranei / i rongoa (i rongoatia i te 90oC mo te 30 meneti).

I whakaatuhia e te aromatawai tukino ihu ko te whakamahi a te SAIB i piki ake te rahi o te paura i te wa o te huri, me te 47% o te rahi o te paura oro i te 1mm.

I whakaritea ki te roopu whakahaere, ko te nui o te tangohanga o te SAIB i roto i te wai, 0.1%N HCl me te 0.1%N NaOH solvents i heke mai i te 41.3% -42.5%, 24.8% -26.1% me te 37.4% -50.6%. Ko te whakamahi i nga whakarewa pararopi mo te tangohanga ka puta he toenga piri he uaua ki te haere i roto i nga momo huarahi whakahaere (hei tauira, werohia, horomia, hongi, he aha atu), hei aukati i te whakamahi tarukino.

whakatau

Ko te whakamahinga o te SAIB, kaore he paninga, ka taea te whakauru tika ki te API hei whakaroa i te tuku raau taero me te whakatutuki i te tukunga pumau.

Ko te SAIB Hydrophobic, ka taea te marara i roto i te wai me te awhina o nga whakarewa pararopi, ka taea te whakamahi me te apis hydrophobic, hydrophilic ranei; Ka taea e te SAIB te whakapai ake i te whakarewatanga o te API me te ngoikore o te wairewa, he pai te whakarewa me te kawe mo te API he ngoikore te wairewa.

Ko te whakamahinga o te SAIB ka aukati i te whakamahi tarukino ma te whakanui ake i te rahi o te matūriki o te raau taero i te wa e paopaohia ana, ka whakararu i te tangohanga raau taero, me te whakararu i te rongoa ki nga momo huarahi whakahaere.

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