Youdaoplaceholder0 1.1 ???? ?????????? ?????? ????? ?

?????????? ????? ????? ??? ??????, ?????????????????? ???????? ??????? ?????????????????? ?????????????? ????? ???? ???? ???: ????????????? (??? ?? ??????? ??? ?????????), ?????????????? (??? ?? ???????), ??? ????????????? (??? ?? ???????). ?????, ??????? ????????? ???????? "?????? ???" ????? ??? - ?? ???? ????? ???????? ?????? ???? ?? ???? ????????????? "??????? ????????" ????? ???. ????? ??????????? ???????? ??????? ???? ??? ??? ?????????? ????????? ???? ??????????? ????? ??????? ?????? ???????? ??????? ????. ????? ??????, ?? ?????????????????? ??-???? ?????????????? ???????????????? ???????????? ??? ??? ???? ????? ????????? ?????? ??????? ???????????? ?????? ???? ????.

?

Youdaoplaceholder0 1.2 ????? ???????????? ?????????????? ???????????? ??????????? ?

???? ???? ???????? ???????????, ???????? ????????? ??? ????? ??? ?? ????????? ?????? ??????????? ????????? ?????????????? ????? ??????????????? ????????? ???????? ???? ????. ?? ??????????? ????????? ???? ?????? ??????????? ?????? ????? ???. ????? ???? ??????? ?????? ?????? ???? (CRUK) ?? ???? ?????????? ???????? ??? ???????? ???????? ????????? ????????????? ????????????? ???? ?????? ????? ????: ??????????????? ???????????? ?????????? ??????????, ?????????? ??????? ??% ????? ?????????? ?????????? ?????? ?? ??% ??? ???? ??? ????????? ??? ??????????????? ??????? ????????, ???????? ???????? ??????? ?.? ?? ?????. ?? ?????? "???? ????? ?????????? ?????????? ?????" ?? ????????? ????? ?????? ????? ???.

?

Youdaoplaceholder0 ?????? ? ????????????? ????????? ?????: ??? "???? ??????" ???????? ???????? ?????? ?

Youdaoplaceholder0 2.1 ????????? ?????: ??????????? ????? "?????? ?????"

?????? ??????? "??????? ??????" ????????? ??????????? ??????? ??????? ??????????? ????? ????? ????. CRUK ????? ??????-?? ??????? ???????? ????????????????? ????? ????? ?? ????? ????????????? ???? ???????? ????? ?????????? ??????? ????????????? (GLUT1/3) ?????? ???????????? ?????????? ??????? ??? ????. ?????, ?????? ??????????, ?? ????????????????? ?????-?-??????? (M6P) ????? ?????? ????????????? ????. ?? ????????? ?????????? ???????????? ??????? ?????? ??? ??? ???? ????? ???????? ????????? ??? ???? "????????? ?????" ???? ????, ???????? ATP ?????????? ????? ???? ??? ?????????????? ??????? ??????? (ROS) ????? ????, ???????? ????? ???????????? ??????? ?????????? ???? ???? (????? ?).

?

Youdaoplaceholder0 2.2 ?????????? ?????: ???????????? ??????? "????? ???" ????????? ?

???? ?????, ??? ?????????????? ????? ?????????????? ??? ?????? ?????? ???? ??? ??? ???? ?? ????? "???????? ?????" ?????? ??? ??? ????. ???????????? ????? ??????????????? (PDAC) ??????????, ????? ???????? ??????? H3K27 ?????? ????????? ????? ????????????? ??? ????, ??????? MYC ??? KRAS ?? ???????????? ???????????????? ?????????????? ?????????? ????. ???? ??????????? ??????, ?? ?????? ?????????????? ?????? ???? ??? - ??? ??????? ??? ???? ?????, ???????????? ???? ?????? ??? ???????? ??????, ???????? ??????? ??????????? ???? ?????? ??????.

?

Youdaoplaceholder0 2.3 ???????????? ??????? ???????? ???????????: PD-L1 ? ?? "????-????? ????" ????? ?????

????? ????? ???????? ???????? ??? ????? ??? ?? ????? ??????????? ??? ????? 1 (PD-L1) ???? ?????????????? ??????????????? ????????? ???? ?????????? ???????????? ????????? ????????? ????? ??? ????. ??? ???????????????? ???????????? ??? ????? ??? ?? ??????? PD-L1 ??????????? 192 ???? ???????? ???????????? N-?????????????? ?????, ???????? ?? ??????????? ????????? ??? ???? ???????? ???? ??????? ?????? ????. "???? ?????" ?? ??????? ???????? PD-L1, E3 ubiquitin ligase FBXW41 ?????? ???? ???? ???? ??? ??????????????? ?? ???? ????. ???????? ???????????, ????? ??? ????-PD-1 ????????????? ??????????? ??????? ?????? ???????? ?? 28% ???? 79% ?????? ????? (????? 2).

?

Youdaoplaceholder0 ?????? ? ????????????? ???????????? ????? ???????? ??????????????: ???????????? ????????? ?????? ????? ?

Youdaoplaceholder0 3.1 ???????????? ?????????? ?????? ??? ??????? ?

CRUK ???? ??????????????? ???????????? ??????????, ??????? ??????????? ?????????? ???????? ????? ???? ???? ???, ?? ????? ???? ?????????? ??????? ????. ?????, FOLFIRINOX ????????? ???????? ??????? ????????, ???????? ?????? ???????? ??????? 42 ??????????? 98 ???????????? ????? ??? ?????????? ??????? ??? ???? ????. ???? ?????? ?????? ????????? ??????-????????? ??????? ?????? ?????????? ?? ?????? ???????????? ??????? ???: ??????? ??????????????? ?????? ??????? ?? 45% ???? 72% ?????? ??????. ?????, ?????????? ????? ????? ??? ?? ?????? 15% ?????? ??????? ???????? ??? ??????. ????? ???????????? ??? ????? ??? ?? ?? ???-????????? ???? ???? ???????? ?????? ?????-??????? ????????? (PMI) ?????, ?? M6P ?? ?????????-6-???????????? ????????? ??? ????? ??? ???????????? ???????? ?????? ?????? ??? ?????.

?

Youdaoplaceholder0 3.2 ????? ?????????? ?? ???? ???? ?

???? ????? ???? ???????? ????????? ??????? ?????????? ???????? ?????????? (NCT05220739) ????? ?? ?????? ???????? ?? ????????? ?????? ????. ? ????? ????????? ????? ????? ???????????? ??? ????, ? ??????????? ?????????? ?????? ????? (ctDNA) ?????? ??% ?????? ????? ?? ????, ???????? ??? ??????????????? ???????????? ??????? ???? ????????????? ?????? ??% ?? ??? ????. ?????, ?????? ??? ?? ????? ?????? ????? ?????? ? ???????????? ????? III ??????? ????, ???????? ?????????? ?????? ????????? ???? ?????? ??? ??? ????? ????. ?????, ????-??????? ????????????? ????????????? ???? ???? ???????????? ????? ????? ?????? ??? ????. ???????????? ???? ???????? ?? ??????? ??????-???????? ????? ??????????? ??% ?????? ??????? ??? ??????? ????????? ????????????? ??? ????.

?

Youdaoplaceholder0 ?????? ? ???????? ???????? ??? ???: ??? ????????? ??? ??????? ?

Youdaoplaceholder0 4.1 ??????? ?????????? ?????? ???????? ?????????? ???? ?????? ?

?????????????? ??????? ????? ???? ??? (?????? ????? ?????????)

????

????????????? ????? ???????? ????? ???? ???? ??? (?????)

??????? ?????? ?? ????????? ???

???? ???? ?????? ??? ???? ???), ?? ????????????? ????? ???????? (??-?? ????? ????????) ????? ???? ???? ???. ???????? ???????? ?????? ??????????????????? ??????????? ????????? ?????-? - ????????? ??????? ??????????? (??????) ??????? ??? ???? ??????? ?? ?????/???? ?????? ?????? ????? ??? ???? ??/???? ?????? ??? ???? ???. CRISPR-Cas9-??????? ???????????? ???????????? ?????????? ?????????? ??????? ???? ????? ??????????????? ??? ?????? ??????? ????-??????? ????? ???????? ???? ??????? ?? ??? ???.

?

Youdaoplaceholder0 ?.? ??????? ?????? ??? ????????? ????????????? ??? ?

"????????????? ????" ?? ???????? ???????? ??? ??????, "?????????? ??????? ?????" ???????? ???? ?????? ????? ????? ????? ???????? Amazon ???????????? ????? ??? ????, ????????? ????? ????? ????? ????. ???? ?????, ???? ??????? ?? ?????????? ??????? ????? ???? ????, ????? "???????? ???? ???????? ??????? ?????????? ?????? ???????? ???? ??? ???" ???? ?? ????. ?????????????? ????? ??? ?? ??????? ???? ??? ?????????? ????????? ?????????? ????????????? ??????? ??? ???? - ????????????? ???????????? ??? ????? ??? ??? ?? ???????? ???? ???????? ???????????????? ???????????????? ????? ???????? ??% ?? ???? ??? ???????????????? ???????????????? ????? ??? ????. ?????? ?????????? ???????????? ???????? ????? ??????? ???.

?

Youdaoplaceholder0 ????? ?????? ?????????? ???????: ???????-?????? ??????? ????? ??????? ?

Youdaoplaceholder0 5.1 ???? ?????????? ?????????? ??????? ?

?????????? ?????????? ???????? ?????? ???????? ????? ?????? ????? ??? ????. ???????? ??????????? ????? ?????????????? ?????? ?????? "????? ?????????????? ??????" (MSS) ????? ?????? ?????????? GLUT1 ?? ?????????? ?????, ??????????? ?????????? ??? PMI ??????????? ?????? ????? ??????????? ??????? ???????? ???????? ?????? ?????? ????. ??? II ???????? ???????????? ???????????, ????? ???????? ?? ????????????? ≥75% ???? MSS ?????? ???????? ??????????????? ???????????? ????????? ??????????? ????????? ???? ????.

?

Youdaoplaceholder0 5.2 ???? ???????????? ???? ? ?? ?????-?????? ??????

???????? ????????? ???? ??????? ??? ??????? ?????? ??????? ????. ?????? ????? "?????-?????????????" ??????? ???? ???? ???, ?? ?????? ??????????? ????????? ???? ??????? ????? ??? ????????? ??????? ???????? ????? ????? ????. ????????? ???????????? ????????????, ?? ????????? ??????-???? ????????? ????????? ??????????????????? ?????? ???? ??? ?????? ?????????????????? 60% ??? ????. ?????? ??? ???? ?????????????? ???? ?? ?? ??? ???: ??????? ??????????????? Ce6 ?? ??????? ????, ???-?????? ????????????? ?????? ???? ?????? "????-?????? ???????????? ?????" ?????? ???? ???? ???, ?? ??? ?????? ?????????????? ?????? ???????.

?

Youdaoplaceholder0 ????????: ????????????? ???????? ????????? ?????? "??? ????" ?

??????? ????????????? ?????? ?? ?????? ??????? ??? ???????? ????????? ?????????? ??????? ?????? ?? ??????? ????? ???. ?????? ??????????????? ?? ???????????? ????????????, ?????????????? ?? ?????? ?????????????, ?? ??????? ???? ???????? ??????????? ???????? ?????? ??????? ???? ???? ???. ??? ??????????????????? ???????? ?????? ??? ????????????, ??? ???????? ??????? ??? ?????? ?????? ????????? ?????????? ????? ????? ???? ???? ???, ????????? ????????? ????????? ??? ??? ???? - ??? ????? ????????? ?????? ????? ????? ????? ?????? ??? ??, "?????????? ??? ??????? ???????? ??? ??? ??????????? ???????? ?????? ?? ?????? ????????? ?????????? ??????????? ??? ????." ???? ??? ??? ??????? ??????????????? ?????? ??????? ?????????, ?? "??? ???????" ??????? ??????????? ???? ?????? ??????? ??? ????.