?????? ???????? ????? ??? ?? ??????????????? ???????????? ?????, ??????? ??? ??? ????????? ?????, ???? ??? ?????, ??? ????? ??? ??? ?????? ?????? ????????? ??????? ??? ?????? ?????? ?????? ?????? ?????. ?????????? ????? ?????? ???? ??? ?????? ???? (?????? ????) ????????, ??????? ???????????? ??????? ???????? ????????? ????? ??? ?????????? ????? ????. ?????? ?????????? ?????? ????? ?????? ?????, ?? ??????????? ????? ????????? ?? ???. ??, ????????? ??? ????? ??????? ????? ??? ??????? ????? ???? ??????????? ?????? ??? ???-??????? ?????? ??????????? ??? ????? ???? ?? ?????? ????????????, ?????????? ???????? ??????? ?????? ?????? ???.

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??????????? ?? ????? ???????? ?????? ????? ?????????? ?? ??? ??? ???????? ???????????????? 5-?????????????????????? (5-HT, ?????? ????????? ????? ???????) ?? ????????? ???. ?????? ???????? ?????????? ??? ????? ??? ??? ?? ??????????? ?????? ????????? ???????, ?????, ?????????????? ??????? ????? ?????? ???????? ????? ????? ???. ????? ????, ??????????? ??? ?????? ?????????? 5-HT ??? ??? ????? ??????????? ??????? ????? ?????? ?????. ??, ?????????? ???????????? ??????????, ??????????? ?????? ????? ??? ?? ??? ???????? ???-??????? ?????????? ???????? ??????? ??? ??? ?? ?????? ?????? ????, ?????????? ???????? ?????????? ?????? ?????? ????.

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?????, ?????????? ???????? ???? ???? ?????????? ???-??????? ?????? ???????? ????? (CMS) ?????? ????. ??????? ???????? ??? ?? ???? ?????????? ???, ?????? ?????? ??? ??? ???????? ????? ???? ????????? ????? ??????????? ??????? ???? ????, ???????? ???????? ?????? ???, ????? ??????? ??????? ?????. ??????????? ??? ????? ??? ?? ?? ?????????? ?????????? ????????, ???????? ??????? ????? ??? ????????????? ????? ????????? ????. ?????? ?????????? ???????? (OFT) CMS ??????? ???????? ?????? ?????????? ????????? ????? ????????? ??? ????????????? ??? ??????? ???, ???????? ??????? ????? ????? ????? ???. ????? ???????????? ???????? (TST) CMS ?????? ???????? ????????? ??? ????????????? ??? ??????? ???, ???????? ???????? ????? ?????. ????? ????, CMS ?????? ???????? ???? ???? ????????????? ?????, ????? ??? ????????????? ??? ????, ???????? ??????? ??? ??? ?????? ???????? ???????? ????? ????.

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????????, ?????????? ?????????? ???????? ??????????? ?????? ???????? ???????? ?????? ???????? ????. ??????????? ??? ????? ??? ?? CMS ?????? ?????????? ???? ????????????? ?????? ????????????? ??? ???? ????, ?? ??????????? ???????????? 5-??????????????????????? (5-HT) ??? ?????????????? ?????? ????????????? ????? ????. ????? ???????????? ??? ????? ??? ?? 5-??????????????????????????? ???????????? ?? ?????? ?????? tph1 ?? mRNA ??????????, CMS ?????? ?????????? ???? ????????? ????????????? ???-?????? ???? ??? ???????? 5-HT ?? ?????? ????? ??? ??? ????? ????. ?????? ??? ????? ???? ?? ?????????? ??? ?????????? ????????????? ????????? ???????????-5-HT ?????? ?????????? ????????????????? ??????? ????, ??????? ?????? 5-HT ??????? ??????? ????.

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??? ??????????? ????-????????? ?????????? ??? ??? ??? ???? ???, ?????? ?????????? 5-HT ????????? ???????????????? ???????????????? ?????? ?????????? ?????? ?????? ??? ???, ???? ??? ???? ????????? ???? ??????? ???????????? ????? ??????? ?????? ???. ?????????? ???????????????? ??? ??????? ?????? ???????? ???? ???????????????? ??? 5-HT ?????????????? ????????????? ??????? ???????? ????. ??????????? ??? ????? ??? ?? ?????????? ???????? AgRP ??? OX1R ??????? ??? ?????????? ???????????????????? ??????????????? ??????? ??? ????, ?? LEPR, MC4R ??? 5-HT1B ??????? ??? ????????? ????????? ???????????? ??? ????. ?????? ??? ????? ???? ?? ???????????-5-HT ?????????? ???????????? ???????????? ?????? ???????? ?????? ???? ???????? ???? ????? ??? ????.

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??, ????????????? ?????? ?????????? ???????? ??????? ???????? ??? ??? ?????????? ????????? ?????????? ??? ??? ???? ??? ????????????? ??? ??? (??? ??????/???? ??? ??? ??????/????) ?????? ???????? ?? ?????????? ????? ????????????? ??????? ???. ??????????? ??? ????? ??? ?? ?? ?????????? ???? ??? ??????????? (??? ??????/????) ?? ??????????????, ?????? ????????? ?????? ??? ????????? ?????? ???????? ?????????? ????? ??? ??????????????? ??????? ??????? ??????? ???? ??? ???????? ??????? ???? ???? ??? ??? ??? ????. ????? ?????????? ??? ????? ??? ??? ?? ????-??? ??????????? ????????? ?????????? ???????? ??????? ???????? ???????????????? AgRP ??? OX1R ??????? ??? ?????????? ????????? ???????? ?????????? ??? ????, ?? LEPR, MC4R, 5-HT1B ??? 5-HT2C ??????? ??? ????????? ????????? ???????????? ??????????? ??? ????. ?? ?????? ??????????? ??? ?? ??? ??????????????? ??? ??? (??? ??????/????) ????? ???????????? ??????????????? ??????? ??????? ???????? ????, ??? ?????? ??????? ???????????? ??? ??????? ???? ??????????????? ??? ???????? ????????? ????.

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????? ?????? ??????? ?????????? ??? ????? ??? ??? ?? 5-HT, ???????????? POMC, AgRP ??? ??? ??????????? 5-HT1B ??? 5-HT2C ?????????? ??????, ??? ?????????? AgRP/NPY ??????????? ?????????? ????, ??? ??? ???????? ??? ????????? ??????? ????? ???????? POMC ??????????? ?????? ???? ??? ???? ??? ??? ??? ????????? ??????? ?????? ??????. ?? ???????????-5-HT ???????????? ?????? ???? ????????????? ???????????? ?????? ??????? ?????? ?????? ????.

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??? ????????? ??????? ?????????????????? 5-HT ?? ?????? ?????? ???? ????????????? ?????????? ???? ???????????? ??????? ??? ???? GT1-7 ?? ????? ???? ????. ?????????? ??? ??????????? ?????? ?????????? ??????? GT1-7 ??????? 10μM ??????????????? (CORT) 24 ??? ????? ????. ??????????? ??? ????? ??? ?? CORT ???????? AgRP ??? OX1R ??????? ??? ?????????? ???????? ?????????? ????????????? ????????? ???? ????, ?? MC4R, 5-HT1B ??? 5-HT2C ??????? ??? ??? ???????? ???????? ?????????? ??? ????. 0.1μM 5-HT ?? 2 ??? ????????????? ??????????, CORt-??????? AgRP ??? ??? ???????? ???????? ?????????? ????????????? ??? ???? ??? ???? ??? MC4R, 5-HT1B ??? 5-HT2C ?? ?????????? ??????????? ???? ??? ????. ?????? ???????????? ??????????? 5-HT ?? ??? ?????? ?????? ?????? ????.

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??????????? ??????????? ?????????? ?????????????? ?????????? ?????? ??????: ?????????? ???????? ???? ????????????? ????? ??? ???? (P

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?????????? ???????? ??? ??? ??????????????? ???????? ????????????? ??????: ????-??? ??????????? ?????????????? ?????????? ???????? ?????? ???????? ???????? ????? ??? ??? ??? ???? (P

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??????? ??????? ??????????? ???????????? ?????? ????????? ??? ??? ?????????? ??????????? ?????????????? ??????: ??????????????????? ????????????? ??? ????? ??? ?? ??????? ??????? ?????????? ??????????????? ARC ???????? c-fos ??? AgRP ?? ?????????? ????????????? ????? ????, ?? LEPR ?? ?????????? ????????????? ??? ???? ???? (P

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??????? ??????? ?????????? ???????????????? ????????????? 5-HT ?????? ???????? ??????: ??????????? ???????????? (P

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???????, ?? ?????????? ??? ????? ??? ??? ?? ?????????? ???????? ???????????-5-HT ?????? ??????? ??????? ???? ??? ???????????? ??? ?????? ???????????? ??????? ????, ???????? ?????? ???? ???? ????. ????????? ????????????? ??????, ??????? ???? ???????? (300mg/kg), ????????? 5-HT ????? ??????????? ????, ???????????? 5-HT1B ??? 5-HT2C ?????????? ?????? ????, AgRP/NPY ??????????? ?????????? ????, POMC ????????? ?????? ???? ??? ????-??????? ??? ????? ??? ???????? ?????????? ??????? ??????? ????.

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?? ??????????? ???????? ?????????? ??????? ?????????? ???. ?????? ??????????, ????? ???????????? ??????, ???? ??????? ???-??????? ?????? ?????? ??? ??? ????????? ???? ?????? ?????. ?????????? ??? ????? ??? ??? ?? ??????????????? ???????? ???????? ????????????? ????? ??? ????, 5-??????????????????????? ???????? ??? ???? ??? ???? ???????????????? ????????? ?????? ??????? ????, ???????? ???????, ????? ??? ??? ????????? ????? ???? ??????, ??????? ??? ??? ?????? ?????? ????????. ?? ?????? ???-?????-??? ????? ?????? ??????????? ??? ???????? ?????????? 5-???????????????????????? ????????? ?????? ????? ????, ???????? ??? ??? ?????????? ??? ??? ????? ??? ??? ????? ????????????? ???? ?????? ??? ?????? ?????? ?????.

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?? ???????????? ??????, ?????? ??????? ?????????? ????? ??????? ??? ?????????? ???? ????????? ??????? ?????. ?????????, ????, ???, ????, ????, ???? ??????? ??????? ?????? ???????????????? ?????????? ????? ???? ???? ?????? ????????????? ????? ??????????, 5-?????????????????????????? ??????????? ????? ??????? ??? ??? ????, ???????? ?????? ?????? ??????? ??? ????????? ???? ????? ????. ?????, ?? ?????? ????? ?????? ?? ???????? ??????????? 100% ????? ??? ???? ??? ?????? ??? ????. ????? ????, ????????????? ?????????? ?????? ??? ???? (??? ?? 500mg/kg ?????? ?????) ???????????? ?????? ??? ????. ??????, ??????? ???? ????????, ????????????? ????? ???? ??? ????, ??????????? ???????? ????? ???? ??????? ?????? ??? ???.

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???????, ??????, ?????, ???? ??????? ????? ???????????? ?????? ??????????? ??? ????????? ??????????? ????? ???? ????, ???? ??? ???? ??? ??? ???????. ?????? ??? ????, ????????? ??? ??????? ????????? ?????? ???? ??? ????? ??????????? ?????? ?????? ????? ?? ???? ??????? ????? ???????? ??????? ????? ????. ??????? ??? ????? ????????? ????? ?????? ????????? ???? ??????, ?????? ?????????? ?????? ????? ???? ?????? ???.

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?????, ?? ?????? ??????????? ?????????? ????????????? ?????????? ???????? ??????? ???????? ?????? ?????????? ????????? ?????? ???? ??? ???? ??? ??????????, ??? ????? ??? ??? ????? ????????????? ?? ???? ????????? ?????? ????. ?????? ??????????? ???? ??????? ??? ??? ??????? ?????? ?????????? ????? ????????? ?????? ?????? ???? ???, ?? ??????????? ????????? ???????? ????????? ???????????? ??????? ??? ?????? ????????? ????? ?????????? ???? ?????? ?????? ?????? ????. ???? ??? ??????? ??? ?? ??????? ????, ????? ???????, ?????? ??? ??? ????????? ?????? ????? ???? ??? ????????? ??????? ???? ??????? ???? ??? ???? ??? ?????? ?????? ???????? ????.