????????? ???, ?????? ??????? ????? ???????, ?? ??????? ????????? ???????? ??? ?? ?????? ????? ???????? ?????????? ??????? ?????? ????. ???????????? ?????????? ??? ????? ??? ??? ?? ????????? ??? ????????? ????? ?????? ?????????? ??? ????, ????????? ????????? ???????? ????? ???? ??? ?????? ??????? ???????????? ?????? ????? ????.

???-?????????? ???? ?????? ????? (NAFLD), ?? ???????? ??????? ?????? ????? ????????? ???????? ??????????? ???, ???????? ??? ?????????? ???? ????? ????, ???????? ??-??% ????? ???? ???-?????????? ???????????????? (NASH) ????? ?????? ?????, ?? ???????????? ???? ??? ????????? ????????? ????????? ????? ????, ???????? ????????????. NASH ?????? ????? ??? ??????? ??? ???? ????????????? ????? ???? ??? ???????? ???? ????? ????.

???????, ?? ???-??? ????????????? ????????? ?????? ??????? ?????????? JAMA ??????? ??? ?????????? "???????? ???????? ????????????? ???????? ??????? ???? ??? ????????. ???? ?????? ???" ?? ????????? ?? ???????? ???????? ????.

?????????? ??? ????? ??? ?? ????????? ??? ?? ??????, ????? ?????????? ???????? ???? ?????? ??? ???????? ???????????? ???? ?????????? ???????? ?????????? ?????? ??, ?????? ??? ???? (≥??.? ?????????/????) ???????? ??????????? ?????? ???????? ???? (≥??.? ?????????/????) ???????? ???????????? ???? ?????????? ???????? ?????????? ?????? ??% ?? ????.

?? ????????, ?????????? ?? ????? ?????? ??????? ?,??? NAFLD ??????????? ????????? ?????? ??? ???? ??????? ????????? (NHANES) ??????????? ???????? ????????? B3 ???? ???? ????, ?????????? ???????? ???? ?????? ??? ???????? ???????????? ???????? ????????? B3 ???? ??? ???? ?????????? ???????? ?????????? ????????? ????????? ???????? ????.

????????? ??? ???? ????????? ??????? ????????? ??? ????????? ?????????? ???: ??? ???? ?? (≤??.? ?????????/????), ????? ???? ?? (??.?-??.? ?????????/????) ??? ????? ???? ?? (≥??.? ?????????/????).
?.? ?????????? ?????? ????-?? ????????, ???? ??? ?????? ??????? ????, ???????? ??? ?????? ???? ? ?????????????????? ????????? ????.

?????????? ??? ????? ??? ?? ?????? ??? ???? ???????? ??????????? ?????? ???????? ???? ???????? ????????? ???? ?????????? ???????? ???????? ???? ?? ????? ??? ????.

????????????, ???? ????????? ???????? ???? ???? ????????? ???? ? ?????????????????? ?????????? ?????? 35 ????? ?? ????, ????? ?? ?????????????????? ???????????? ??????.

????? ?????????? ????????? ??? ?? ???? ??? ?????? ??? ???? ?????????? ???????? ?????????? ?????????? ??????? ??????????? ????? ???, ???????? ?????? ???????? ??????????? ?????? ?????? ???????? ???????????? ?????????? ???? ?? ????.

???????????? ???, ??????? ?? NAD ????????????? ??????????????? ?? ??? ??? ???? ???????? ???????? ??? ??????????? ?? ?????????? ?????? ???? ???. ????????? ????????? ?????????? ????? ????? ??? ??? ?? ??????? ???? ?????? ?????? ???? ??? ???????? ?????? ?????? ??? ??? ????. ???????????? ????????, ??????? ???????? ????????? ??? ???? ????? ??? ??? ???? ??? ?????????? ????? ??? ????? ??? ???. ?? ?????? ???????????? ??? ??? ????, ??????????????? ?????????????????? 2 ??? NADPH ???????? ?????????? ????? ??? ??? ??????? ?????????????? ????? ???? ?????.

?? ????????? ??? ?? ???????? ???? ?????, ?? ???-??? ????????????? ????????? ?????? ??????? ?????????? ????????????? ?????????? "?????? ??????? ???? ??? ???-?????????? ???? ?????? ????????? ?????: NHANES ????-????" ?? ????????? ?? ???????? ???????? ????.

?????????? ??? ????? ??? ?? ????????? ??? ???????????????? ?????????? ?????? ???? ?????? ???? ???????? ???? ??? ????, ??????? ???????? ??????? ???? (≥??.? ??????/????) ???? ??? ??????? ?????????? ?????? ???? ?????? ???? ???????? ???? ?????? ??? ??????? ???? (≤??.? ??????/????) ????????????? ?????? ??% ??? ????.

??????????, ????? ??? ????? ????? ?? ????????? ??3 ???????????? ???-?????????? ???? ?????? ???????? ??? ??????? ??????? ??? ??? ???-?????????? ???? ?????? ??? ???????? ???????????? ???? ?????????? ???????? ???????? ???? ??? ????. NAFLD ???????? ???????????? ???? ?????????? ???????? ???????? ???? ??? ?????????? ????????? ??3 ???? ?????? ????? ?????? ?????????? ????? ?????? ?????? ???.