????????? ?? ??????? ?????? ???. ?? ?? ?????? ???????? ?????? ?????? ??????? ????? ???. ??? ?????? ????????? ??????????? ??????? ????? ???? ?? ????? ????? ????? ???? ????????? ??????? ?????? ?????. ????????? ???????? ???? ??? ?????????? ?? ??? ?????? ?????? ????, ???????? ???? ???????? ???? ??? ?????????? "?????????" ????? "??? ??? ????" ?????? ????? ????.

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????????? ?? ?????? ????????? ?????? ?????? ???-????, ?????-????? ??????? ??????? ???. ????????? ?? ???? ???? (???? ????) ????? ??? ???-??? ??????????????? ????????????? ????????? ???? ???? ?? ????????? ???????? ??? ???????????? ?????? ??? ??????? ?????? ???????? ?????. ????????, ?? ?????? 98% ?????? ????? ???? ????. ?? ???????? ???????????? ????????? ???? ?????????? ?????? 600 ?? ??? ??? ???? ?????? ????. ????? ??????? ?? ??????, ????????????, ?????? ????????? ??????? ??????? ??? ?? ??????? ?????? ???????. ??????? ??????????? ???? ??????????? ????? ????????? ???????? ????????????? ???????? ?????????? ????? ?????: ????? ?????, ????, ????????, ??????? ??? ??????? ????????? ?????????. ??????? ??????? ??????? ??? ????????? ????????? ??? ?????? ??????? ??? ??????? ??????????????? ????????? ???? ?????. ???? ?????? ?????????? ??????, ????????? ???????? ?????? "?????????" ?? ?????? ?????, ?? ??? ???? ????????????? ??????? ?????? ??? ???????????? ???? ????. ??????????? ????????? ????? ??? ???????? ????????? ??? ????, ???????? ?? ???-????? ?????????? ?? ???????? ?????? ????. ??????????????????? ???????????? ??????????? ???? ???? ??? ???? ??? ????? ???????? ????? ?????????? ?????????? ????????? ???. ??????, ??????? ????????? (?????????) ????????? ????, ?? ?????? ???? ?? ????????? ????? ???/????? ???????? ????? ????. ?????? ??? ???????? ?????? ??????????? ????? ???? ????? ?????????? ???????????? ??????? ??????? ???, ???????? ???? ????? ??????????? ??? ???? ????? ?????????????? ???????????? ??????? ??????? ???. ???? ?????, ???? ??? ??? ???? ??????????????? (FDA) ?? ?? ???? ??? ??? ???????????? ???????????? ??????????? ??????? ???? ??? ???? ????? ????????? ???????-???????? ????? ?????? ?????? ???? ??????. ???? ????? ???????? ??????????? ??????????? ???? ??????? ?????? ?????? ???????????? ??????? ??????? ???. FDA ?? ???? ??????? ?????? ?????? ??????????? ????? ????. ????? ????, ??? ??? ?????????????? ?????????????, ??? ?????? ??????? ???????? ???? ???????. FDA ?? ?????????? ???????? ?? ????????????? ?????? ?????????? ??? ???????? ?????????? ?????? ??? ?? ??????????, ?????????????? (???????????????? ????????? ?????? ??????? ???????? ??????) ??? ??????????????? ????????? ?????. FDA ???? ?????????????, ???????? ???????????? ??????????? ????????? ????? ???? (ADI) ????? ????? ??? 5 mg/kg ??????? ??? (mg/kg/day) ?? ??? ???? ???. ?????-????? ??? ??????????????? ????????? ?????????? ??????? ?????

???? ???????? ??????, ????????? ?? ??? ???? ????? ?????????? ??????? ?????? ??? ???? ??? ?????? ?????? ??????? ???? ?????? ??? ??? ????. ???????, ???? ???? (? ???? ????? ?????? ?.? ????? ???? ????????? ?? ?????? ?????) ???? ??????????? ??? ???? ???????? ???? ??? ??? ??????????? ????????? ????????? ?? ?? ???????? ?????? ???. ????????? ?????? ??????????? ?????? ????, ??? ???????? ???????? ????? ? ???? ????????? ??? ???? ????? ??? ?????, ?? ??? ??????????????? ?????????? ???.

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?????? ?????? ??????????? ????????? ?????? ??? ???? ??? ???????? ???????? ??????? ????? ???? ???? (6). ?????? ???????? ?????????? ????????????? ???????? ?????????? ??????, FDA ?? ??? ???????? ????? ??? ?? ???? 2 ?????? ???????? ?????????? ??????????? ????????? ???????? ???? ??????????? ???????? ?????? ??? ????. ????????????, ???????? ???????????? ????????? ??? ????? ??? ??? ?? ???? 2 ?????? ???????? ???????????? ????????? ?????????? ??????? ?????????????? (HbA1c ???????????????????? ??????????????) ?????? ??? ????. ???????, ??? ????? ???? ???????? ???????????? ????????? ?? ?? ???????? ????? ?????? ???. ?????, ????????? ????????? ????????????, ?????? ???????? ??????? ????????????? ????????? ???????????????????? ??????? ???????? ?????? ?????????? ???? ????????? ????????? ???????? ????? ?????????? ??? ?????????? ????? ??????. ??????? ?????? ?????? ??? ?????????? ??? ?????????? ?????????????? ??????????? ????? ????? ???? ???, ??????????? ?????????? ??? ?????? ??????? ?????? ?????? ???? ?????? ???????? ???? ?????. ???????, ?????????????? ??????? ?????, ???????????????? ??? ???????????????????? ?????????? ????????? ?????? ?????? ?????? ?????? ?????????? ??????? ?????.

?????????? ??? ????? ??? ??? ?? ??????????? ??????? ??? ??????, ?????????????? ???? ??????? ?????? ???????? ??? ???????????????? ?????????? ????? ???????? ?????, ??????? ??????????? ???????????. ????????? ?? ????? GLP-1 ????? ??????? ???? ??? ????? ??? ???. GLP-1 ??????? ???????????????? ?????? ??? ??? ????????? ???????-??????? ???????? ????? ??????. ??????????, ????????????? ???????? ????????? ???????? ?????????? ????? ????????? ???????? ?????????? ??? ?????????? ???????? ??????????? ??????? ??? ????. ???????? ??????? ???????????? (???????? ????????? ??????? ?????) ??? ??? ?????? ???????? ??????????? ?? ?????? ????????? ??????? ?????? ?????????? ????. ??????? ?????????? ?????? ??????? ??? ???????? ???????? ????????? ??????? ??????? ???? ??? ???????? ???? 2 ??????, ??????? ??? ?????????????? ??????? ?????? ????????? ??????? ???????? ????. ????????????, ???? ? ?????????????????? ??? ???????? ???? ????????????? ?????. ?????????? ????????? ??? ?????????????? ?????? ??????????? "?????????????? ?????????" ????? ???? ???? ?? ????? ??? ???? ????? ??????? ??????? ????????? ????. ?????? ?? ?????????? ???????????????? ????????? ???????? ?????? ??? ????. ?????, ??? ?????? ???? ?? ????????????? ??????????? ???????? ??????? ???????? ?????????? ????? ??????? ????????????-??????? ????????????? ?????? ?????????? ????????????? ????????????? ???? ????. ???? ????????????? ?????????? ??? ????? ??? ??? ?? ???-????????????? ????????? (NNS) ???? ????????? ?????????? ???????????? ????? ??? ?????; ?????? ???????????? ??????? ?????? ??? ???????? ?????????? ???????????? ??? ?????? ?????? ????? ???. ?????, ????????????? ?????? ???????? ????????????????? ??????????? ???? ??????, ???? ????? ?????? ??? ????????? ??????? ????????? ???????? ??? ????. ??????? ???????? ????????????? ????????? (?? ?????????? ??????? ????????????) ????????? ?????????? ?????? ?????????? ?????? ???????? ???????? ?????? ?????????? ??????????????? NNS ???? ??????? ??????? ????????? ?????????? ????? ??? ??????? ???. ???????? ??? ???????? ????? ???? ?? ????????????? ?????????? ????????????????? ????????? ????? ????? ??????? ??? ???? ?????. ???, ???? ??? ????????? ????????? ????????? ???????? ??? ????? ??? ?? NNS ?? ???????? ???? ???? ????? ???????????????? ?????????? ???????? ?????? ??? ????, ????????? ??????????? ?????? ??????? ?????? ????. ?????, ?? ?????? ???? ?????????? ??? ?? ?????? ???????? ????????????? ????????? NNS ?????????????? (???????????) ?????? ?????? ???? ??? ????? ?????????? ?????????????? NNS ?????????????? ?????? ?????? ???????? ????? ?????????? ????? ??? ???????? ?????? ???. ????? ?????????? ?????????????? ????????? ??? ??? NNS ?? ?????????? ?????? ?? ???? ????????? ??????? ???.

???????????? ???? ??? ??? ????? ??? ????????? ?????-????? ????? ????, ??? ?? ??? ?? ???????????? ???????? ????, ???????????? ???????? ????? ??????? ???? ??? ?????????? ???????? ????? ?????? ?????? ??????? ???? ????. ??????????? ???????????, ?????????? ??? ????? ?????? ?????? ?????? ??? ????????? ??????????????? ?????? ?????. ?????? ?? ????? ??? ??? ???? ??? ???? ??? ???????? ??????? ?????. ??? ????????? ???????? ??????????, ???? ????? ????????? ???? ????? ???????? ??? ?????? ??????????? ??????? ????????? ?????????????? ??????? ?????????? ????????, ???????? ????????? ????????? ????? ???? ?????. ?? ?????? ??? ?????? ?????? ???? ?? ????????? ??? ??? ??????? ??? ?????????? ???? ??? ??? ????? ?????, ????? ???? ??? ???????? ??? ????? ??? ????????? ??????? ???.