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22. HMB Ca: Muscle Maker?!

2025-03-13

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Your muscles are leaving you as you age! If you don't build muscle, you'll be more likely to gain weight than others, and sitting for too long will create a "swim circle." Middle-aged and elderly people, such as parents and grandparents, often feel that their limbs are weak and they struggle to climb stairs, which is also because of the loss of calcium with age, resulting in bone problems. It was found that HMBCa could solve these problems. For the fitness crowd, can provide muscle health nutrition supplement. For middle-aged and elderly people can help prevent osteoporosis, muscle decay; HMBCa is also known as the "muscle maker".

In addition, medical studies have found that HMBCa can also help people with tumors restore muscle health.

Studies have shown that supplementation of 3 grams per day of calcium beta-hydroxy-beta-methylbutyrate (HMB), a natural metabolite of the body's essential amino acid leucine, can inhibit or even reverse skeletal muscle loss. The human body can naturally produce, can also be found in nature (such as beef, eggs, broccoli, etc.), but it is trace, in order to maintain the muscle health of cancer patients, or must be supplemented by exogenous HMB.

What is HMBCa

HMB is widely found in citrus fruits, certain vegetables such as broccoli, legumes such as alfalfa, and certain fish and seafood. In industrial production, in order to facilitate storage and use, HMB is usually converted into calcium salts during synthesis, often used in monohydrate, namely β-hydroxy-β-methylbutyrate calcium monohydrate.

HMB is an active metabolite of the essential branch chain amino acid leucine, which can promote protein synthesis and reduce its breakdown, thereby increasing human body strength, delaying muscle fatigue, and also helping to prevent muscle atrophy in the elderly.

Since 2011, the new food raw material HMB? has been highly concerned by domestic food enterprises. In 2017, the National Health and Family Planning Commission announced the expansion of the application scope of HMB? from the original two applications to nine.

HMBCa application

1. Action mechanism and safety of HMBCa

Beta-hydroxy-beta-methylbutyric acid (HMB) is a metabolite of leucine. Branched chain amino acids constitute more than 30% of the protein in muscle, among which leucine is the only amino acid that can regulate protein turnover in skeletal muscle and heart muscle, which can regulate muscle synthesis, prevent protein degradation and recovery of sports injury.

HMBCa is one of the common complementary forms of HMB, and it is a new resource food raw material approved by the Ministry of Health in China, and its safety has been extensively studied. In human studies, a daily intake of 6gHMB was not found to have any effect on cholesterol, hemoglobin, white blood cells, blood sugar levels, liver and kidney function after 1 month of consumption. Baier studied the daily consumption of 2 to 3gCaHMB with amino acid mixture in the elderly, and no changes were found in liver blood and kidney and blood lipids after 1 year of consumption.

2. Application of HMBCa in animal nutrition

Studies have shown that the application of HMBCa in meat poultry can improve the growth performance and increase the lean meat content, so as to effectively increase the meat yield, and the addition of HMBCa feed can improve the growth of livestock and poultry and enhance animal immunity.

Guo Junqing et al. selected healthy Inner Mongolia white wool goats and added different concentrations of HMBCa and leucine in the basal diet. The results showed that the addition of leucine and HMBCa in the diet can increase the content of serum lysozyme, increase the content of serum immunoglobulin and enhance the immune function of the body.

3. Application of HMBCa in sports nutrition

Studies have shown that consuming calcium beta-hydroxy-beta-butyrate after exercise can not only accelerate the repair of muscle tissue, but also promote muscle volume growth, increase endurance, and improve strength.

In October 2013, the International Society of Sports Nutrition (ISSN) conducted a rigorous and detailed analysis of the literature on HMB as a nutritional supplement and made the following statement. ① For exercise-induced skeletal muscle injury in trained and untrained people, HMB can reduce muscle injury and promote recovery. Athletes will benefit from training and supplementing with HMB. ③ Supplement HMB before exercise for 2 weeks for the best results. Appropriate exercise in trained or untrained people, coupled with a daily supplement of 38mg/kg·BMI of HMB, can promote skeletal muscle growth and increase muscle strength and strength. The effects of HMB include reduced protein degradation and increased protein synthesis.

4. Application of HMBCa in formula food for special medical purposes

Formula food for special medical purposes has important clinical significance in correcting metabolic imbalance, reducing complications such as infection, enhancing the effect of various treatment means, promoting recovery, thereby shortening hospital stay and improving patients' quality of life.