Under the double background of the high incidence of chronic diseases and the awakening of national health awareness, a "intestinal revolution" driven by dietary fiber is quietly reshaping the global health industry pattern. According to the World Health Organization (WHO), about 75% of the global population faces insufficient dietary fiber intake, while the average daily fiber intake of Chinese residents is only 50% of the recommended value (25-30g). In this urgent need, a water-soluble dietary fiber named ? Polydextrose ?, with its excellent physiological functions and wide application scenarios, has moved from the laboratory to the public table and become the "super ingredient" that the nutrition community and the food industry pay common attention to. Based on scientific evidence, clinical cases and industrial practice, this paper comprehensively reveals how polyglucose can leverage the multi-dimensional value of metabolic health, immune enhancement and chronic disease prevention through intestinal microecological regulation.

First, scientific evidence: Four core health mechanisms of polyglucose ?

Polyglucose is made from the polymerization of glucose, sorbitol and citric acid, and its unique 1, 6-glucoside bond main chain and complex branch structure give it the characteristics of digestion and absorption by the human body, but play a key role in the gut "invisible regulator".

?1. Gut health: from microbiota balance to immune barrier strengthening ?

The prebiotic properties of polyglucose have been certified by the European Union EFSA (European Food Safety Authority). Studies have shown that it can selectively promote the proliferation of beneficial bacteria such as ? bifidobacteria, Lactobacillus ? and inhibit the growth of pathogenic bacteria such as Escherichia coli (Gut Microbes, 2023).

? short-chain fatty acid (SCFA) factory ? : intestinal flora ferment polyglucose to produce SCFA such as butyric acid and propionic acid, which not only provides energy for colon cells, but also reduces intestinal pH value and reduces ammonia toxoid absorption. Japan's National Institute of Health found that daily intake of 10g of polyglucose can increase fecal butyric acid concentration by 40% (Nature Communications, 2022).

? physical barrier repair ? : SCFA promotes the expression of intestinal mucosal compact junction protein by activating G protein-coupled receptor (GPR43) and reduces the risk of intestinal leakage. A Clinical trial in patients with inflammatory bowel disease (IBD) showed that after 6 weeks of polyglucose supplementation, measures of intestinal permeability (such as serum connexin) decreased by 35% (Clinical Nutrition, 2023).

?2. Blood sugar control: The carb speed bump ?

Polyglucose can delay the rate of gastric emptying and form a sticky gel in the small intestine, preventing the diffusion of glucose to the intestinal wall. A double-blind trial conducted by the China Center for Disease Control and Prevention and Jiangnan University confirmed that 5g polyglucose intake before meals in patients with type 2 Diabetes reduced the peak blood glucose by 22% and increased insulin sensitivity by 18% 2 hours after meals (Diabetes Care, 2024).

? Resistant starch synergistic effect ? : In low GI foods, the combination of polyglucose and resistant starch can further inhibit α-amylase activity and prolong glucose release time. The hot ? Yili "Shuhua sugar friend milk" ? adopts this formula and has become a popular product in the diabetes market segment.

?3. Lipid metabolism intervention: a "natural regulator" of cardiovascular health ?

Polyglucose reduces serum total cholesterol (TC) and low-density lipoprotein (LDL) by absorbing bile acids and promoting their excretion, forcing the liver to use cholesterol to synthesize new bile acids. A 10,000-person cohort study funded by the American Heart Association (AHA) found that people who consumed 15g of polyglucose daily had a 31% lower risk of cardiovascular events (Circulation, 2023).

? New evidence for liver protection ? : Animal experiments show that polyglucose can inhibit the expression of fatty acid synthase (FAS), reduce lipid deposition in liver, and have potential improvement effects on non-alcoholic fatty liver disease (NAFLD) (Journal of Nutritional Biochemistry, 2023).

?4. Weight management: a "long-acting trigger" of satiety signals ?

Polydextrose absorbs water and expands in the stomach, stimulating mechanical receptors to signal fullness to the brain. Experiments conducted by the British Nutrition Society showed that subjects who added 10g of polyglucose to their breakfast had 18% fewer calories at lunch and 27% fewer hunger scores (British Journal of Nutrition, 2023). International weight management brand ?Optifast? launched a high-fiber meal replacement powder with polyglucose as its core ingredient, which has captured 30% of the global meal replacement market share.

? Industrial practice: Technological breakthroughs from the laboratory to the consumption scene ?

The high temperature resistance, high solubility and low calorie (1kcal/g) properties of polyglucose make it an ideal vehicle for innovation in the food industry. The global polyglucose market is expected to grow from $1.25 billion in 2023 to $2.87 billion in 2030 (12.4% CAGR), with China emerging as the fastest growing regional market (Grand View Research, 2024).

?1. Functional food innovation cases ?

? dairy products upgrade ? : Mengniu's "Guanyi Milk · Fiber +" series added polyglucose and Lactobacillus plantarum, focusing on the double effect of "intestinal + immunity", the sales volume exceeded 100 million in the first month of listing.

? snack health ? : Three squirrels launched the "crispy series" of high-fiber cookies, which replace 50% sugar with polyglucose and contain 5g fiber in a single packet, with annual sales of more than 200 million packets.

? Special medical food application ? : Nutricia "Best Food You choose" full nutrition formula powder, through polyglucose regulation osmotic pressure, reduce the risk of diabetes patients diarrhea, national special medical food registration (TY-2023-012).

?2. Regulations and Standards Escort ?

China's "National Standard for Food Safety Food Additive Polyglucose" (GB 25541-2024) was formally implemented in July 2024, clarifying its purity ≥99%, lead ≤0.2mg/kg and other indicators, and in line with the International CODEX Alimentarius Commission (CODEX) standards, laying the foundation for the standardized development of the industry.

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? Third, consumer insight: health demand driven market fission ?

?1. Crowd segmentation and scene development ?

? Silver economy ? : For the elderly constipation problem, Tomson Bihealth "Jianli multi-fiber powder" through the pharmacy channel penetration, repurchase rate of 65%.

? Maternal and child nutrition ? : Feihe "Xingfeifan Zhuorui" infant milk powder added polyglucose, focusing on "intestinal affinity + brain development", the market share ranks first in domestic high-end milk powder.

? sports nutrition ? : Keep co-named ffit8 launched "fibrin bar" to meet the needs of fitness people for filling control card. There are more than 100,000 notes related to Xiaored Book.

?2. Science Communication and Consumer education ?

?KOL matrix construction ? : Djing Doctor and a hundred nutritionists launched the "Fiber Awakening Program", which reached more than 50 million users through live science popularization of the "gut-immune axis" mechanism of polyglucose.

? Functional Claim specification ? : The State Administration for Market Regulation requires that polyglucose products labeled "help maintain normal intestinal function" should provide at least 2 clinical evidences, promoting the industry from "concept marketing" to "evidence marketing" transformation.

? Four, challenges and the future: decode the next station of technology outlet ?

?1. Technical bottleneck breakthrough ?

? molecular customization ? : Through enzyme engineering to modify the polymerization degree of polyglucose, to develop special products for constipation (low polymerization degree) or diabetes (high polymerization degree).

? microencapsulation technology ? : spray drying is used to bury polyglucose to solve the stability problem in acidic beverages, and it is extended to new categories such as sparkling water and functional tea drinks.

?2. The Sustainable Production revolution ?

Tate & Lyle, a leading global supplier ?, ?, is investing $120m in a biofanking facility that uses synthetic biology to convert cornstarch into polyglucose, reducing carbon emissions by 70% compared with conventional processes and achieving International Sustainability Certification (ISCC PLUS).

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? Five, expert opinion: polyglucose "golden decade" ?

?Dr. Robert Lustig (Metabolic disease specialist, University of California, San Francisco) ? :

"The value of polyglucose lies not only in its fiber properties, but also in its regulation of the systemic metabolic network through the gut flora. In the next decade, personalised nutrition based on polyglucose will disrupt the chronic disease management paradigm."

? Wang Xingguo (Vice Chairman of the Chinese Society of Nutrition) ? :

"The dietary fiber gap of Chinese residents is as high as 15g/ day, and the industrial application of polyglucose provides an efficient solution for the" national fiber supplement ". We expect more local companies to make breakthroughs in raw material preparation technology and reduce their dependence on imports."

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? Conclusion ?

From improving gut microecology to reducing the risk of chronic diseases, polyglucose is reshaping the human health landscape in a way that is "smooth and silent." With the deepening of scientific research and the iteration of industrial technology, this health revolution driven by molecular-level innovation may lead us to a new era of national health "with the gut as the axis".

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