Safety of Cysteamine Hydrochloride
1、 Basic security nature
Physical and chemical risks
Easy to deliquescent and oxidize, appears green when exposed to iron ions and may produce toxic products. It should be stored in a cool, dark and sealed place.
Danger signs: Harmful if swallowed (R22), irritating to eyes/respiratory tract/skin (R36/37/38).
Toxicity and allergenicity
Acute toxicity: Animal experiments have shown no significant toxicity at conventional doses, but high doses (such as cows>75g/day) can inhibit rumen fermentation and reduce volatile fatty acid synthesis.
Allergen risk: In cosmetics (especially hair dye concentrations of 5-12%), it may cause skin erythema, dryness, or allergic contact dermatitis; Eye contact can damage visual function.
2、 Safety in the field of agriculture and animal husbandry
Feed additives
Safe dosage:
Pigs/poultry: Adding 300-600g/ton of feed is safe and effective, and it needs to be coated to avoid irritation to the gastric mucosa.
Ruminant animals: Cows weighing ≤ 150g/day and beef cattle weighing 80mg/kg body weight did not significantly affect health, but>75g/day may disrupt rumen microbiota protein synthesis.
Discontinuation period: No need to set a cessation period, it belongs to green regulators (illegal hormones).
Environment and Residue
After metabolism, there are no harmful residues, and both the EU and China have approved it as a legal feed additive.
By improving the utilization rate of nitrogen and phosphorus, indirectly reducing aquaculture pollution.
3、 Daily chemical and pharmaceutical fields
Cosmetics risks
5% concentration of whitening/hair dye products may damage the epidermal barrier and increase the risk of occupational dermatitis (such as long-term exposure by hairdressers).
Periocular use can induce abnormal vascular proliferation, corneal damage, and visual impairment (confirmed by zebrafish model).
Medical applications
Strict dosage control is necessary when treating cystine storage syndrome, and common side effects include gastrointestinal reactions (nausea, diarrhea) and rash.
As an antidote (such as acetaminophen poisoning), it has high safety, but it is necessary to avoid contact with metal ions