The anti-inflammatory effect of vitamin E is mainly achieved through multiple synergistic pathways, and the specific mechanism is as follows:

1. Inhibit the inflammatory signaling pathway
Vitamin E increases sphingolipid levels, activates anti-inflammatory protein A20, blocks TNF - α - induced activation of the NF - κ B signaling pathway, thereby inhibiting the expression of NF - κ B protein and reducing the intensity of inflammatory response.
NF - κ B is a key transcription factor that regulates pro-inflammatory cytokines, and inhibition of its activity can reduce the production of inflammatory mediators.
2. Neutralize free radicals and reduce oxidative stress
Vitamin E indirectly inhibits oxidative stress-related inflammatory responses by clearing free radicals and reducing cellular damage caused by oxidative stress.
3. Directly inhibit the release of inflammatory mediators
Inhibit the release of pro-inflammatory and chemokines by inflammatory cells such as neutrophils and macrophages, and alleviate local tissue inflammatory responses.
Reduce the production of lipid peroxidation products (such as malondialdehyde) and avoid their stimulation of inflammatory signal cascade amplification.
4. Regulating immune cell function
Enhance the anti-inflammatory activity of immune cells, such as inhibiting overactive T and B cells, and balancing immune responses.
Protect the membrane structure of immune cells, maintain their normal function, and prevent uncontrolled inflammatory reactions.
Specific applications of anti-inflammatory effects
Skin inflammation: Relieve skin redness and swelling caused by ultraviolet radiation or external stimuli, inhibit tyrosinase activity, and reduce the risk of pigmentation.
Chronic inflammatory disease: it can help relieve arthritis, atherosclerosis and other chronic disease symptoms related to inflammation