Mwachilengedwe, mannose amakhalapo mwaulere mu zipatso zina, monga cranberries, maapulo, malalanje, ndi zina zotero. Mu thupi la munthu, mannose amagawidwa m'magulu onse ndi magazi, kuphatikizapo khungu, ziwalo ndi mitsempha. Mu minyewa iyi, mannose imakhudzidwa ndi kaphatikizidwe ka glycoproteins omwe amayendetsa ntchito ya autoimmune system. Kafukufuku wam'mbuyomu wachipatala awonetsa kuti mannose amatha kuchiza ndi kupewa matenda amkodzo, kotero kuti mankhwala ena akunja okhala ndi mannose monga chigawo chachikulu amagwiritsidwa ntchito kuti asunge thanzi la mkodzo.

Zadziwika kale kuti zotupa zimafunikira kwambiri glucose kuposa minofu wamba. Ma cell a chotupa amatha kutenga shuga wambiri kuwirikiza ka 10 kuposa maselo abwinobwino ndipo amadalira kwambiri glycolysis kuti apeze mphamvu kuti akule mwachangu. Komabe, chotupa cha "shuga ngati moyo", pamaso pa mannose, koma mkhalidwe wosiyana unachitika. Mu 2018, magazini ya Nature idasindikiza kafukufuku wa blockbuster kuchokera ku Cancer Research UK kuti mannose amatha kuletsa zotupa. Ofufuzawo adapeza kuti mannose ikalowa m'maselo otupa, imachulukana m'maselo ngati mannose 6-phosphate, kutsekereza mphamvu ya chotupacho posokoneza kagayidwe ka glucose, motero imalepheretsa kukula kwa maselo otupa. Pofuna kutsimikizira mfundo imeneyi, ofufuza anachita kufufuza zina mu mbewa chotupa chitsanzo, iwo anawonjezera mannose kwa madzi akumwa a "khansa" mbewa izi, ndi kuwunika zotsatira za m`kamwa mannose pa mankhwala a mitundu yosiyanasiyana ya khansa monga khansa ya m'mapapo ndi khansa ya m'mapapo mu mbewa. Zotsatira zake zidawonetsa kuti makonzedwe amkamwa a mannose mwa kumwa madzi amachedwetsa kukula kwa chotupa mu mbewa. Atatsimikizira kuchiritsa kwa mannose pachitsanzo cha chotupa cha mbewa, ofufuzawo adaganiza zopereka mannose kwa mbewa kuwonjezera pa mankhwala amankhwala a adjuvant, ndipo adadabwa kupeza kuti mannose amawonjezera chithandizo chamankhwala a chemotherapy, osati kungochepetsa kuchuluka kwa chotupa mu mbewa, komanso kukulitsa moyo wa "cancerous" mbewa. Chaka chino, gulu lofufuza la Fudan University lapeza njira yatsopano yolimbana ndi khansa ya mannose - kuwongolera molekyulu ya chitetezo chamthupi PD-L1. Kodi chotupa immune checkpoint ndi chiyani? Tikudziwa kuti matupi akunja monga mabakiteriya akunja ndi ma virus akalowa kapena ma cell am'thupi afa kapena kukhala ndi khansa, chitetezo chamthupi la munthu chidzayatsidwa, ndipo chitetezo chamthupi chidzagwira ntchito pambuyo poyatsidwa kuti achotse "mamolekyu achilendo" awa. Pa nthawi yomweyo, pofuna kupewa kwambiri kutsegula kwa chitetezo cha m`thupi ndi "kupha mosasankha" wa bwinobwino minofu minofu m`thupi, pali ya "chitetezo chitetezo mamolekyu" mu thupi lathu. PD-L1 ndi molekyu yofunikira ya chitetezo chamthupi m'thupi lathu, yomwe imatha kumangirira ku molekyulu ya PD-1 pamwamba pa maselo a chitetezo chamthupi ndikutumiza chizindikiro cha "brake" ku maselo a chitetezo chamthupi kupewa kupha maselo abwinobwino ndi maselo amthupi (Chithunzi 2). Komabe, dongosolo ananyema mu thupi lathu amadyeredwa mochenjera maselo chotupa, ndi maselo T mu chotupa microenvironment ndi udindo kupha zotupa, ndi chotupa maselo adzamasula "ananyema" chizindikiro kwa T maselo kudzera mkulu mawu a mamolekyu PD-L1, kuletsa ntchito ya maselo T, kuti kupewa kupha chitetezo cha m'thupi.

Molekyu ya PD-L1 ndi puloteni yodzaza ndi kusintha kwa glycosylation. Gulu lofufuza la Fudan University linapeza kuti mannose amatha kuwononga kukhazikika kwa mapuloteni a PD-L1 poyendetsa glycosylation ya mamolekyu a PD-L1, motero amalimbikitsa kuwonongeka kwa mamolekyu a PD-L1. Chifukwa chake, pamene molekyulu yodziwika bwino ya PD-L1 m'maselo a chotupa imawonongeka ndi mannose, kodi maselo otupawa sangakakamize ma T cell "kuswa"? Ofufuzawo adatsimikizira kuti: maselo otupa omwe amachiritsidwa ndi mannose amatha kuphedwa ndi maselo a T; Mu mbewa chotupa chitsanzo, m`kamwa mannose akhoza kulimbikitsa kuwukiridwa ndi kupha maselo T kwa chotupa ndi ziletsa kukula kwa chotupacho, ndi kuphatikiza mannose ndi chitetezo chitetezo antibody mankhwala kumapitiriza kulimbikitsa kuukira ndi kupha maselo T kwa chotupacho, ndi kumawonjezera kwambiri moyo wa "khansa" mbewa.

Monga tanenera kale, mannose amapezeka mwachibadwa mu zipatso zina, makamaka cranberries zomwe zimakhala ndi mannose apamwamba kwambiri (Chithunzi 3). Anthu ambiri amadzifunsa kuti, kodi kudya cranberries kungalepheretse kapena kuchiza khansa? M'malo mwake, kuchuluka kwa mannose omwe amaperekedwa kwa mbewa za "khansa" m'maphunziro awiri omwe ali pamwambawa anali okwera mpaka 20%, zomwe zikutanthauza kuti 100ml iliyonse yamadzi akumwa imakhala ndi 20g ya mannose, yomwe imakhala yochuluka kwambiri komanso mlingo. Choncho, timadya cranberries ndi zipatso zina kuonjezera kudya mannose, kumlingo, akhoza kulimbikitsa chitetezo chokwanira, zabwino thanzi, koma ndikufuna kukwaniritsa zotsatira za odana ndi khansa cranberries yekha kutali mokwanira.