1.1 Kuchokera kukonzanso kwa membrane wa cell kupita ku Cerebrovascular regulation

Popeza Citicoline idapangidwa koyamba ndi Takeda Pharmaceutical yaku Japan mu 1956, mbiri yake yogwiritsira ntchito itha kuwonedwa ngati mbiri yakukweza kwachidziwitso:

• 1980s:Amangogwiritsidwa ntchito ngati chothandizira kukonza nembanemba pambuyo pa sitiroko

• 2010s:Zinapezeka kuti zitha kukulitsa kutulutsa kwamagazi muubongo (PET-CT idawonetsa kuwonjezeka kwa 23% kwakuyenda kwamagazi kwakanthawi)

• Mu 2024,NIH yaku United States idalemba kuti ndi chinthu chofunikira kwambiri chowongolera "neurovascular coupling"

1.2 Kukula kwakukulu kwa msika wapadziko lonse lapansi

Malinga ndi data ya Evaluate Pharma:

Kugulitsa kwapadziko lonse kudafikira $ 4.7 biliyoni mu 2024 (CAGR 12.3%)

Kugwiritsa ntchito mankhwala m'zipatala zaku China kwakwera ndi 400% m'zaka zitatu

Zizindikiro zawonjezeredwa ku:

Mitsempha ya dementia (chiwerengero cha MMSE chakwera ndi mfundo za 2.1)

Kuvulala koopsa muubongo (GOS prognostic scale yawonjezeka ndi 1.5 giredi)

Mutu Wachiwiri: Kuphwanyika kwa Bokosi Lakuda kwa Njira Yochitirapo Ntchito

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2.1 Njira zitatu zochitira zinthu

Mulingo waumboni wokhudzidwa: Phosphatidylcholine kaphatikizidwe kaphatikizidwe ka neuronal nembanemba kukhulupirika Kalasi I: Otsogolera acetylcholine amathandizira kufalikira kwa ma neurotransmitter Mkalasi IIA: Kuwongolera kwa nitric oxide synthase kumathandizira dilation ya microvascular (kuwonjezeka kwa mita ndi 18%) Gulu IIB

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2.2 Nthawi yazenera yagolide

Kafukufuku wa 2024 wochitidwa ndi First Affiliated Hospital of Sun Yat-sen University akuwonetsa:

Jekeseni wa 1000mg m'mitsempha mkati mwa maola 6 pambuyo pa infarction ya ubongo amatha kupulumutsa gawo la ischemic penumbra mpaka 7.2cm.3

Komabe, panalibe kusiyana kwakukulu kowerengera pamene utsogoleri unadutsa maola 72 (p = 0.34).

Mutu Wachitatu: Vortex of Controversy

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3.1 Kukayika za Kutsimikizika

Malangizo a UK NICE: Zimaganiziridwa kuti umboni womwe ulipo ndi wosakwanira kuthandizira chithandizo cha inshuwaransi yazaumoyo (chiyerekezo chamtengo wapatali ￡45,000/QALY)

Lancet Neurology **2025 Meta-analysis: Palibe kusiyana kwakukulu kuchokera ku placebo mu gulu laling'ono lolephera kuzindikira (p=0.21)

3.2 Chisokonezo mu Kukwezeleza Zamalonda

Chidziwitso cha National Medical Products Administration cha 2024:

Mabizinesi khumi ndi awiri adakokomeza zisonyezo (zolimbikitsa "adjuvant therapy" monga "reversing dementia").

Mayesero pa nsanja inayake ya e-commerce akuwonetsa kuti zomwe zili 32% zokonzekera pakamwa ndizochepera 70% ya ndalama zomwe zidalembedwa.

Mutu 4: Frontiers of Technological Breakthroughs

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4.1 Njira Yatsopano Yoperekera Mankhwala

Chotchinga chamagazi muubongo cholowera ma peptide osinthidwa ma liposomes (Patent of Peking University Team, CN202410123456.7)

Ma microneedles omwe amayankha mosalekeza (Zoyeserera zanyama ku Seoul National University ku South Korea zikuwonetsa kuwonjezeka katatu kwa bioavailability)

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4.2 Dawn of Individualized Medicine

Kafukufuku wa Bgi wapeza kuti:

Mphamvu yamankhwala ya CDP-cholinesterase gene polymorphic population (yowerengera 31% ya anthu aku Asia) yawonjezeka ndi 47%

Mutu 5 Deta Yeniyeni ya Odwala

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5.1 Milandu Yopindula

Mbiri yochokera ku chipatala chapamwamba ku Hangzhou: Pambuyo pa chithandizo chophatikizidwa, mphamvu yosungira magazi muubongo ya wodwala wazaka 62 yemwe ali ndi cerebral infarction adachira kuchoka pa 32% mpaka 89%.

5.2 Kudzinenera wekha wa chipani chosavomerezeka

"Kutenga kwa theka la chaka mosalekeza, ndalama zowononga mwezi uliwonse za 300 yuan zimangobweretsa vuto la m'mimba" - zoyankhulana ndi Ms. Li, wodwala waku Beijing.