Anthu opitilira 500 miliyoni padziko lonse lapansi ali ndi matenda a shuga, 90% mwa omwe ali ndi matenda amtundu wa 2. Odwala amayenera kuwongolera kusinthasintha kwa shuga m'magazi moyo wawo wonse, ndipo shuga wamba (monga sucrose ndi fructose) amalembedwa ngati zotsutsana ndi zakudya chifukwa amapangitsa kuti shuga m'magazi achuluke. Komabe, kufunikira kwa thupi laumunthu la kukoma kokoma n'kovuta kuthetsa, ndipo zolowa m'malo mwa shuga zinayamba kukhalapo. Sucralose, monga chotsekemera cham'badwo wachinayi, chakopa chidwi chambiri chifukwa cha "zopatsa mphamvu zopanda mphamvu komanso kutsekemera kwakukulu" 13.

2. Makhalidwe a metabolism ndi chitetezo cha sucralose
1. Ubwino wa metabolic
Maselo a sucralose amasinthidwa ndi chlorination, yomwe siiwonongeka ndi michere ya m'mimba ya anthu. Pafupifupi 85% ya sucralose imatulutsidwa mwachindunji kudzera m'matumbo pambuyo pa kumeza, ndipo 15% yotsalayo imapangidwa ndi chiwindi kukhala zinthu zopanda poizoni ndikutulutsidwa mumkodzo. Maphunziro azachipatala atsimikizira kuti index yake ya glycemic ndi 0, ndipo palibe kulumikizana kwachindunji ndi insulin secretion 12. Mwachitsanzo, kuyesa koyendetsedwa ndi International Diabetes Federation (IDF) mu 2024 sikunawonetse kusintha kwakukulu pakusala kudya kwa shuga m'magazi ndi milingo ya A1C mwa odwala 50 omwe ali ndi matenda amtundu wa 2 omwe amamwa zakumwa za sucralose kwa masiku 30 otsatizana 5.

2. Kusanthula kwa dialectical mikangano yachitetezo
Ngakhale kuti kafukufuku wodziwika bwino amathandizira chitetezo chake, pali zodetsa nkhawa zomwe zingachitike:

Matenda a m'matumbo a microbiota : Kafukufuku wa 2024 wofalitsidwa mu Nature Microbiology anasonyeza kuti kudya kwa tsiku ndi tsiku kwa 15g ya sucralose kumalepheretsa ntchito za probiotics monga bifidobacterium, zomwe zinachititsa kuchepa kwa 20% -30% m'matumbo a microbiota 37;
Kuyanjana kwa mankhwala: Mukaphatikizidwa ndi anticoagulant warfarin, sucralose imatha kuchepetsa bioavailability wamankhwala ndi 12% -15%. 27 iyenera kutengedwa maola awiri motalikirana;
pa
Kuwopsyeza kwa mankhwala: Kuphika kutentha kwambiri (> 150 ℃) kumatha kutulutsa kuchuluka kwa chloropropanol (Chachitatu, njira yasayansi yosinthira shuga m'malo
1. Kuwongolera kwa mlingo kumasinthidwa ndi zochitika
Bungwe la World Health Organisation (WHO) limalimbikitsa kuti anthu omwe ali ndi matenda a shuga asamadye kupitilira 9mg/kg ya sucralose tsiku lililonse (pafupifupi 540mg kwa munthu wamkulu wolemera 60kg). Zitsanzo ziyenera kusiyanitsa muzochitika zothandiza:

Chakumwa chakumwa 300ml chili ndi 30mg sucralose, yomwe ndi 5.5% yokha ya malire otetezeka 16;
Zowotcha ?: Sankhani makeke opangidwa ndi kutentha pang'ono (2. Kasamalidwe kazakudya kophatikizana
M'malo mwa shuga salowa m'malo mwa kuwongolera shuga:

Zakudya zopatsa thanzi : Phatikizani mbewu zonse (GI pansi pa 55) ndi ulusi wazakudya (25-30g tsiku lililonse) kuti muchedwetse kuyamwa kwa shuga 46;
Kuwunika kwa shuga m'magazi : Glucose wamagazi adadziwika patatha maola awiri mutadya zakudya zolowa m'malo mwa shuga, ndipo mbiri yamunthu payekhapayekha 58 idakhazikitsidwa.
4. Miyambo yamakampani ndi maphunziro ogula
1. Kukhazikika kwa zilembo za chakudya
Ndondomeko yosinthidwanso ya General Rules for Nutrition Labeling of Prepackaged Foods mu 2025 imafuna kuti zakudya zomwe zili ndi sucralose ziyenera kulembedwa ndi chenjezo lakuti "Odwala matenda a shuga ayenera kuletsa kudya kwathunthu kwa carbohydrate" ndikuwonetsa zowonjezera (mg/100g) 24.

2. Kuyankha kwachisokonezo cha msika
Mu 2024, General Administration of Market Supervision adapeza kuti 18.7% ya "zopanda shuga" zimasunga shuga wowonjezera, womwe umakhala ngati sucralose. Ogwiritsa ntchito ayenera kusankha zinthu zomwe zili ndi satifiketi ya SC ndi malipoti athunthu oyesa 78.

5. Chitukuko chamtsogolo
1. Kusintha kwaukadaulo
Mu 2025, Jinhe Industrial idakhazikitsa njira ya "kuwongolera chlorination" kuti achepetse kuchuluka kotsalira kwa sucralose chloropropanol mpaka 0.01ppm, ndikuwonjezera nthawi yotulutsa matumbo kudzera muukadaulo wa microcapsule kuti muchepetse kusokonezeka kwa bakiteriya 18.

2. Kafukufuku wachipatala wozikidwa pa umboni
International Diabetes Association yakhazikitsa pulogalamu yazaka 5 ya "shuga m'malo ndi metabolic syndrome" kuti iwonetsere chitetezo chanthawi yayitali cha sucralose mwa anthu 100,000 omwe ali ndi matenda ashuga.