Mu 1832, katswiri wa zamankhwala wa ku France Michel Eug è ne Chevreul anapeza creatine mu minofu ya chigoba, yomwe pambuyo pake inatchedwa "Creatine" kuchokera ku liwu lachi Greek "Kreas" (nyama). Creatine imasungidwa makamaka mu minofu ya minofu, yomwe imatha kuchepetsa kutopa ndi kupsinjika kwa minofu, imapangitsa kuti minofu ikhale yolimba, imapangitsa kuti minofu ikhale yolimba, imathandizira kaphatikizidwe ka mapuloteni m'thupi la munthu, kuchepetsa mafuta m'thupi, mafuta a m'magazi, ndi shuga wamagazi, kuchepetsa kukalamba, komanso kuchitapo kanthu pamene kufunikira kwa mphamvu kuli kwakukulu. Powonjezera creatine, thupi la munthu limatha kuonjezera nkhokwe za creatine, kupititsa patsogolo kuchuluka kwa phosphocreatine mu minofu, komanso kupititsa patsogolo masewera olimbitsa thupi kwakanthawi kochepa. Kafukufuku wasonyeza kuti creatine zowonjezera sizingachedwetse kutopa kwa minofu, kupititsa patsogolo mphamvu zothamanga za othamanga ndi kupirira, komanso zimathandizira kulimbikitsa kukula kwa minofu ndi kuchira, zomwe zimapangitsa kuti zikhale zowonjezera zakudya zowonjezera kwa okonda masewera olimbitsa thupi ndi othamanga.