HMB ndi metabolite wapakatikati wa munthu wofunikira amino acid leucine, ndipo thupi la munthu limatha kupanga pang'ono HMB yokha. Muzakudya zabwinobwino, thupi la munthu limatulutsa pafupifupi 300 mpaka 400 mg patsiku, pomwe 90% imachokera ku catabolism ya leucine. HMB ingagwiritsidwe ntchito kulimbikitsa kukula kwa minofu, kupititsa patsogolo chitetezo cha mthupi, kuchepetsa mafuta m'thupi ndi kuchepa kwa lipoprotein otsika kwambiri m'thupi kuti achepetse kuyambika kwa matenda a mtima ndi matenda a mtima, komanso kupititsa patsogolo luso la kukonza nayitrogeni m'thupi, kusunga mapuloteni m'thupi, komanso kuteteza kuwonongeka kwa minofu kwa odwala omwe ali pabedi kapena olumala. M'zaka zaposachedwa, chifukwa zimatha kuchepetsa kuwonongeka kwa minofu pambuyo pochita masewera olimbitsa thupi, kukonza ulusi wa minofu, kuonjezera mphamvu za minofu ndikuwotcha mafuta a thupi, zakhala chinthu chofunika kwambiri pa masewera olimbitsa thupi. Kuphatikiza apo, HMB yatsimikiziridwa mwachipatala kuti imathandizira machiritso a bala ndikuletsa kutupa. Kafukufuku wasonyeza kuti Ca HMB imatha kufulumizitsa kaphatikizidwe ka mapuloteni ndikuchepetsa kudya kwa mapuloteni. Ca HMB yophatikizidwa ndi glutamine ndi arginine imatha kupititsa patsogolo kusakwanira kwa nayitrogeni kwa odwala ndikuthandizira kuti achire kuvulala ndi opaleshoni.

Mu 2011, Unduna wa Zaumoyo ku China wakale udalengeza kuvomereza kwa β-hydroxy-β-methylbutyrate calcium (Ca HMB) ngati chakudya chatsopano, kugwiritsa ntchito masewera olimbitsa thupi chakudya, chakudya chamankhwala chapadera chogwiritsa ntchito mankhwala, kuchuluka kovomerezeka ndi ≤3 magalamu / tsiku. Mu 2017, National Health and Family Planning Commission idalengeza zakukula kwa kuchuluka kwa ntchito za Ca HMB kuchokera pazofunsira ziwiri zoyambirira kufika pa zisanu ndi zinayi, ndipo idalamula mabungwe owunika zaukadaulo kuti aziwunika chitetezo. Kugwiritsiridwa ntchito kwa Ca HMB kunakulitsidwa kuti kuphatikizepo zakumwa, mkaka ndi mkaka, mankhwala a koko, chokoleti ndi chokoleti, maswiti, zinthu zophikidwa, ndi zakudya zapadera za zakudya, ndipo ndalama zovomerezeka zikadali ≤3 g / tsiku, zomwe sizinapitirire mlingo wa anthu odzipereka odzipereka. Ca HMB idadziwika kuti GRAS ndi US Food and Drug Administration mu 1995 ndipo imagwiritsidwa ntchito muzakudya zopatsa thanzi komanso zakudya zapadera. M'zaka 20 zapitazi, Ca HMB yakhala ikugwiritsidwa ntchito kwambiri muzamkaka, chokoleti, zakumwa, mipiringidzo yamagetsi ndi zakudya zina pamsika waku US. Ca HMB ndi zakudya zopangira zakudya zomwe zimaloledwa ndi malamulo a ku Japan, zomwe zingathe kuwonjezeredwa m'madera ambiri monga chakudya wamba, zakudya zamasewera, zakudya zochepetsera thupi, zakudya zokongola, ndi zina zotero. Kwa opanga ndi ogulitsa mankhwala, Ca HMB pakadali pano ndi imodzi mwazinthu zodziwika bwino zathanzi pamsika waku Japan.