1, makina apakati

Bakiteriya yolimbana ndi metabolite glyoxylate

Mabakiteriya osamva mankhwala amawongolera mawonekedwe a glyoxylate m'malo opanda michere, omwe amasinthanso mawonekedwe a epigenetic, amachepetsa mayankho a chitetezo chamthupi, ndipo amathandizira mabakiteriya kukhala ndi moyo pansi pa kukakamizidwa ndi maantibayotiki poletsa ntchito ya DNA demethylase (TET2) m'maselo omwe amalandila.

Vitamini C imayendetsa ntchito ya enzyme ya TET2

Vitamini C, monga choyambitsa chachilengedwe cha TET2, imatha kuthana ndi kulepheretsa kwa glyoxylate pachitetezo cha chitetezo cha mthupi, kubwezeretsa ntchito ya DNA demethylation, ndikuyambitsanso chitetezo chamthupi.

Kusokoneza njira ya "imfa yabodza" ya mabakiteriya

Acetaldehyde nthawi yomweyo imayendetsa njira yodzitchinjiriza ya mabakiteriya, kupanga olimbikira kuti apewe kupha maantibayotiki. Vitamini C wophatikizidwa ndi maantibayotiki amatha kusokoneza kagayidwe kachakudya kameneka ndikuchepetsa kwambiri kuchuluka kwa bakiteriya.

2. Umboni woyesera

Kutsimikizika kwachitsanzo cha zinyama: Muchitsanzo cha matenda a mbewa, kuphatikiza kwa vitamini C ndi maantibayotiki kumawonjezera kupulumuka ndi 60%, kuchepetsa kuchuluka kwa mabakiteriya mu minyewa ndi 80%, ndikuchepetsa kuchuluka kwa zotupa ndi 50%.

Mphamvu ya Synergistic: Vitamini C imakulitsa njira yowonetsera interferon (IFN), imalimbitsa mphamvu ya chitetezo cha mthupi kuchotsa mabakiteriya osamva mankhwala, ndikuletsa STAT1 dephosphorylation, kutalikitsa kuyankha kwa anti-chotupa.

3, chipatala ntchito kuthekera

Kuthana ndi vuto la kukana mankhwala: Njirayi imapereka chithandizo chatsopano chosadalira maantibayotiki cha matenda a bakiteriya osamva mankhwala monga Salmonella ndi Mycobacterium TB, makamaka kwa odwala omwe ali ndi matenda obwerezabwereza kapena maantibayotiki osagwira ntchito.

Dongosolo losavuta la chithandizo: Vitamini C, monga chopatsa thanzi komanso chotsika mtengo, angagwiritsidwe ntchito limodzi ndi maantibayotiki omwe alipo kuti achepetse mlingo wa mankhwala ndi kuchepetsa zotsatira zoyipa.

Chitetezo chowonjezera chamtengo wapatali: Kudya mokwanira kwa micronutrients (monga vitamini C) kungachepetse mosadukiza chiwopsezo cha kufalikira kwa jini yolimbana ndi mankhwala mwa kusunga matumbo a microbiota.

4. Njira zofufuzira zamtsogolo

Yang'anani zotsatira za synergistic ndi kuphatikiza kwabwino kwa vitamini C ndi maantibayotiki ena monga beta lactam ndi quinolones.

Unikani zotsatira za kuwonjezereka kwa vitamini C kwa nthawi yayitali pakusintha kwa mabakiteriya osamva mankhwala.

Kupanga mankhwala oletsa mabakiteriya omwe akulunjika ku glyoxylic acid-TET2 axis