Lycopene (LYC), carotenoid, ndi pigment yosungunuka ndi mafuta, makamaka yomwe imapezeka mu tomato, mavwende, manyumwa ndi zipatso zina, ndiye mtundu waukulu wa tomato wakucha. Lycopene ili ndi maubwino osiyanasiyana azaumoyo, kuphatikiza kuwononga ma radicals aulere, kuchepetsa kutupa, kuwongolera shuga ndi lipid metabolism, ndi zotsatira za neuroprotective.

Posachedwapa, Ofufuza ochokera ku yunivesite ya zachipatala ya Shanxi adasindikiza pepala mu nyuzipepala ya Redox Biology yotchedwa "Lycopene imachepetsa kuperewera kwa chidziwitso chokhudzana ndi zaka pogwiritsa ntchito ubongo wa chiwindi. Pepala la kafukufuku wa fibroblast kukula factor-21 signing ".

Kafukufuku wasonyeza kuti kuwonjezera ndi lycopene kwa miyezi ya 3 kumatha kuchedwetsa kukalamba kwa ubongo mu mbewa ndikuchepetsa kuwonongeka kwa chidziwitso chokhudzana ndi ukalamba, ndipo lycopene imathandizira kuwonongeka kwa neuronal, kuwonongeka kwa mitochondrial, kuwonongeka kwa synaptic, ndikulimbikitsa kuphatikizika kwa synaptic vesicle mu mbewa zokalamba.

Kuphatikiza apo, lycopene idayambitsa chiwindi-ubongo axis FGF21 chizindikiro mu mbewa zokalamba, potero kulimbikitsa kutulutsidwa kwa ma neurotransmitters mwa kukulitsa mitochondrial ATP milingo ndikuwonjezera kuphatikizika kwa synaptic vesicular. Izi zikusonyeza kuti FGF21 ikhoza kukhala chandamale chachipatala mu njira zothandizira zakudya zochepetsera ukalamba wa ubongo ndikuwongolera kuwonongeka kwa chidziwitso chokhudzana ndi ukalamba.

Mu ukalamba, ukalamba wa ubongo, kusokonezeka kwa mitochondrial ndi chimodzi mwa zinthu zofunika kwambiri, ochita kafukufuku anapeza kuti lycopene supplementation ikhoza kupititsa patsogolo kuwonongeka kwa mitochondrial morphological, ndi kubweza mlingo wa mitochondrial electron transport chain complex chifukwa cha ukalamba, kulimbikitsa kupanga ATP, kusonyeza kuti lycopene imakhala ndi chitetezo cha mitochondrial.

Pomaliza, ofufuzawo adachitanso zoyeserera mu vitro ndipo adapeza kuti lycopene imathandizira kuti ma cell a chiwindi athandizire ma neuron, kuphatikiza kuwongolera ukalamba wa cell, kupititsa patsogolo ntchito ya mitochondrial, ndikuwonjezera kutalika kwa ma neuron axon.

Kuphatikizidwa pamodzi, zotsatira zimasonyeza kuti lycopene supplementation ikhoza kuchedwetsa ukalamba wa ubongo ndikuletsa kuwonongeka kwa chidziwitso kwa zaka zapakati pa mbewa, mwa zina chifukwa lycopene imayambitsa hepato-brain axis FGF21 chizindikiro, kutanthauza kuti FGF21 ikhoza kukhala chithandizo chochiritsira muzochita zolimbitsa thupi kuti zithetse matenda okalamba omwe amadza chifukwa cha kusokonezeka kwa ubongo.