Citicolinewakhala akugwiritsidwa ntchito kwambiri muzochita zachipatala, makamaka pofuna kuchiza matenda a ubongo omwe amayamba chifukwa cha kuvulala kwa craniocerebral kapena ngozi ya cerebrovascular, ndipo wapeza ntchito zatsopano muzochita zachipatala. Chithandizo chake mu kukha magazi muubongo, matenda a Parkinson, glaucoma, diabetesic peripheral neuropathy ndi tinnitus ndi matenda ena adakopanso chidwi. Ndiye kodi citicoline ndi chiyani, zotsatira zake zamankhwala, zomwe zikuwonetsa (mankhwala enieni a matenda), mphamvu ndi chitetezo?

Citicoline ndi nucleotide imodzi yopangidwa ndi ribose, cytosine, pyrophosphate ndi choline. Ndi endogenous nucleotide ya thupi la munthu. Imakhudzidwa ndi njira zambiri zofunika za metabolic m'thupi. Ndi kalambulabwalo wachilengedwe wa phospholipid kaphatikizidwe ka neuron cell membrane kapangidwe ndi kalambulabwalo wa biosynthesis wa neurotransmitter acetylcholine.

Citicoline ndi neuroprotective wothandizira omwe amatha kuteteza ma neuron omwe ali pachiwopsezo, potero amachepetsa kapena kupewa kukula kwa matenda. Pakadali pano, ma neuroprotective agents omwe amagwiritsidwa ntchito kwambiri pazachipatala amaphatikizapo calcium channel blockers, glutamate antagonists, free radical scavengers, ndi cell membrane stabilizers, zomwe citicoline ndi ya cell membrane stabilizers.

Citicolineili ndi zotsatira zamankhwala osiyanasiyana, ndipo njira zochitira izi zimapangitsa kuti ikhale ndi kuthekera kwakukulu pakuteteza mitsempha ndi kukonza minyewa. Ili ndi neuroprotection effect yolepheretsa kuchitika kwa kuvulala kwa neuronal ndi kukonzanso kwa mitsempha pambuyo pa kuvulala kwa minyewa, komwe kumakulitsa nthawi yochizira ya citicoline.

Kutengera ndi mankhwala ake, citicoline imagwiritsidwa ntchito kwambiri pochiza sitiroko, kuwonongeka kwa chidziwitso, kuvulala koopsa kwa ubongo, matenda a Parkinson, glaucoma, matenda a shuga a peripheral neuropathy, tinnitus ndi matenda ena, ndipo mphamvu yake ndi chitetezo chake zatsimikiziridwa m'maphunziro angapo azachipatala, ndi umboni wokwanira wachipatala. Stroke: sitiroko ndi mtundu wa kutsekeka kwa mitsempha yaubongo kapena kupasuka, zomwe zimapangitsa kuwonongeka kwa ubongo kwa gulu la matenda, kuphatikiza ischemic ndi hemorrhagic sitiroko, yomwe sitiroko ya ischemic ndiyo mtundu waukulu wa sitiroko, yomwe imatenga 75% mpaka 90% ya zikwapu zonse. Chiwopsezo cha moyo wa sitiroko mwa anthu athu ndi 35% -40.9%, kusanja koyamba padziko lapansi, osati kokha, sitiroko ndi chifukwa choyamba cha imfa ndi kulemala kwa okhalamo.

Umboni wofufuza zachipatala:

1. Mu 2002, American Journal Stroke inafalitsa meta-analysis ya mayesero a zachipatala kwa odwala pachimake ischemic sitiroko, amene anasonyeza kuti oral citicoline anawonjezera mwayi odwala sitiroko achire pambuyo 3 miyezi [1].

2. Mu 2009, kufufuza kafukufuku wofufuza mankhwala kunachitika ku South Korea kwa odwala 4191 omwe ali ndi vuto lalikulu la ischemic, ndipo zotsatira zake zinasonyeza kuti citicoline inapititsa patsogolo chiwerengero cha NIHSS ndi chiwerengero cha BI cha odwala omwe ali ndi phindu kumayambiriro ndi mochedwa chithandizo, ndipo zopindulitsa za nthawi yayitali zinali zazikulu, ndipo zotsatira zochiritsira zinali zogwirizana bwino ndi mlingo. Kuwongolera kunali kofunika kwambiri pagulu la mlingo waukulu (≧2000mg / tsiku), ndipo kugwiritsa ntchito nthawi yayitali kunali kotetezeka komanso kulekerera [2].

3. Zotsatira za kafukufuku woyendetsa maulendo ambiri, osasinthika, awiri akhungu, oyendetsedwa ndi placebo pa ubongo wamagazi amasonyeza kuti citicoline ndi mankhwala otetezeka ochizira matenda a ubongo omwe ali ndi zotsatira zabwino zochiritsira [3].

4. Phunziro lotseguka, losasinthika, lofanana linayesa zotsatira za citicoline pa vuto lachidziwitso cha pambuyo pa sitiroko, ndipo zotsatira zake zimasonyeza kuti kugwiritsa ntchito citicoline kwa nthawi yaitali kunathandiza kwambiri kuwonongeka kwa chidziwitso pambuyo pa sitiroko [4].