Kukalamba ndizovuta, zochitika zambiri, pang'onopang'ono zomwe zimachitika m'moyo wonse. M'kupita kwa nthawi, ziwalo ndi minofu ya thupi la munthu adzakalamba pang'onopang'ono, ndipo matenda ena adzachitikanso ndi kukula kwa msinkhu, kuphatikizapo khansa, shuga, matenda a mtima ndi zina zotero.

Kafukufuku wochulukirapo awonetsa kuti ma phytochemicals, kuphatikiza ma polyphenols, flavonoids, terpenoids, ndi zina zambiri, amatha kutalikitsa moyo wathanzi kudzera mu anti-oxidation, activation ya mitochondrial autophagy ndi njira zina, ndikukhala ndi anti-aging properties.

M'mbuyomu, ofufuzawo adapeza kuti kuchotsa kwa tchire kumatha kuchedwetsa kukalamba mu kuyesa kwa m'galasi, ndipo mu mbewa ndi zitsanzo za anthu mu m'galasi, tchire la tchire limachepetsa kwambiri kuchuluka kwa maselo a sidase a beta-galactose okhudzana ndi ukalamba, omwe akuwonetsa anti-kukalamba.

Posachedwapa, Ofufuza a pa yunivesite ya Padova ku Italy anasindikiza pepala m'magazini ya Nature Aging yotchedwa "Kuyang'ana senescence chifukwa cha msinkhu kapena mankhwala amphamvu omwe ali ndi polyphenol-rich. chilengedwe chimapangitsa kuti moyo ukhale wautali komanso thanzi la mbewa."

Kafukufuku wasonyeza kuti kudya kwa tsiku ndi tsiku kwa mchere wa sage kumatha kukulitsa moyo ndi moyo wathanzi wa mbewa, kuletsa kutupa kwaukalamba, fibrosis ndi zolembera zaukalamba m'magulu osiyanasiyana, komanso kusintha ma phenotypes okalamba.

Mu kafukufukuyu, ofufuzawo adasanthula kuthekera kwa anti-kukalamba kwa sage extract (HK) mu vivo kudzera pamitundu ya mbewa, powonjezera Mlingo wochepa wa HK kumadzi akumwa a tsiku ndi tsiku, ndikuwunika kuchuluka kwa maselo amtundu wa mbewa, komanso magawo angapo okhudzana ndi zaka, kuphatikiza moyo wautali, thanzi lathupi, fibrosis, mineralization ya mafupa, ndi kutupa.

Ofufuzawo anapatsa mbewa za miyezi 20 madzi akumwa okhala ndi HK mpaka atamwalira.

Zotsatira zake zinawonetsa kuti nthawi yayitali ya mbewa mu gulu lachipatala la HK inali miyezi 32.25, pomwe nthawi yayitali ya mbewa mu gulu lolamulira inali miyezi 28 yokha. Chithandizo cha HK chinakulitsa nthawi ya moyo ndi miyezi 4.25, ndipo nthawi ya moyo wa mbewa zazikazi ndi zazimuna zidakulitsidwa kwambiri.

Histopathological kusanthula khungu, chiwindi, impso, ndi mapapo a mbewa anapeza kuti HK mankhwala sanabweretse kusintha kwa hematopoietic magawo kapena chiwalo kawopsedwe, kusonyeza kuti HK mankhwala ndi otetezeka.

Kuphatikiza apo, chithandizo cha HK chinapangitsa kuti ma phenotypes okalamba azikula mu mbewa poyerekeza ndi zowongolera, kuphatikiza mbali za hunchback, kukula kwa chotupa, komanso ubweya wanyama.

Zotsatirazi zikuwonetsa kuti chithandizo cha HK chikhoza kutalikitsa moyo wathanzi komanso moyo wautali wa mbewa, ndipo palibe poizoni omwe amawonedwa.

Kufufuza kwina kunapeza kuti chithandizo cha HK chinapangitsa kuti ma phenotypes okalamba azikalamba m'magulu osiyanasiyana, kuphatikizapo kutayika tsitsi, mafupa, thanzi la minofu, ndi impso.

Kusanthula kwamakina kunawonetsa kuti chithandizo cha HK chidachepetsa kwambiri jini yokalamba SAUL_SEN_MAYO, pomwe ma jini okalamba omwe amawongolera amalumikizidwa ndi kutupa, kuyambitsa chitetezo chamthupi, ndi njira zokhudzana ndi ukalamba, zomwe zikuwonetsa kuti chithandizo cha HK chinasintha mawonekedwe a transcriptome okhudzana ndi kutupa ndi ukalamba. Kuphatikiza apo, kusanthula kwa minofu, khungu, impso, ndi mapapo adapeza kuti chithandizo cha HK chinachepetsa kuchuluka kwa zolembera zaukalamba m'magulu osiyanasiyana m'thupi.

Kuphatikiza pa ukalamba wachilengedwe, ofufuzawo adapezanso kuti chithandizo cha HK chingalepheretsenso kukalamba komanso mtima wamtima womwe umayambitsidwa ndi mankhwala a chemotherapy doxorubicin, ndikusungabe chithandizo chake.

Pomaliza, chifukwa HK ndi chotsitsa chomwe chili ndi zigawo zosiyanasiyana za zomera, ochita kafukufuku adasanthula zosakaniza zomwe zimagwira ntchito yolimbana ndi ukalamba, ndipo zotsatira zake zimasonyeza kuti gawo la flavonoid, luteolin (Lut), ndilo gawo lothandizira la HK anti-aging, lomwe limapangitsa kuti ukalamba ukhale wabwino mwa kusintha kuyanjana pakati pa p16 ndi CDK6.

Kuphatikizidwa pamodzi, phunziroli linapeza chotsitsa chachilengedwe chokhala ndi zotsatira zotsutsana ndi ukalamba zomwe zimathandizira kukalamba kwa maselo ndi minofu, kupititsa patsogolo zizindikiro zokhudzana ndi ukalamba monga ubweya, humpback, kudzikundikira zizindikiro za ukalamba ndi kuwonongeka kwa DNA mu minofu, komanso moyo wautali wa nyama.