Youdaoplaceholder0 1.1 Matsenga akuthupi a viscosity gradient: Kusintha Katatu kuchokera m'mimba kupita m'matumbo

Mapangidwe a mamolekyulu a polyglucose amapangidwa ndi zotsalira za glucose zomwe zimalumikizidwa mwachisawawa, ndipo mawonekedwe apaderawa amamupatsa mawonekedwe apadera a rheological. M'mimba ya acidic kwambiri (pH 1.5-3.5), maunyolo ake a molekyulu amatha kupanga maukonde amitundu itatu kudzera m'mabondi a haidrojeni, ndipo kukhuthala kumawonjezeka kufika pa 1200 mPa·s (pafupifupi kawiri kuposa uchi), mogwira mtima kuchedwetsa kukhuthula kwamimba mpaka 40% ndi kukhuta. Pambuyo polowa m'matumbo aang'ono, pamene pH mtengo umakwera kufika 6.0-7.5, zomangira zina za haidrojeni zimasweka ndipo kukhuthala kumatsika mpaka 300-500 mPa · s. Simalepheretsa kwambiri kuyamwa kwa michere kapena kuphatikiza ndi bile acid kuti muchepetse kuyamwa kwa cholesterol. Mukafika m'matumbo, pansi pa mphamvu ya tizilombo toyambitsa matenda, kukhuthala kumachepa mpaka pansi pa 50 mPa · s, kutulutsa mafuta afupiafupi (SCFAs) kuti apereke mphamvu kwa ma probiotics (Chithunzi 1).

?

Youdaoplaceholder0 Data Support :

?

Kuchedwetsa kutulutsa m'mimba: 40% (Chakudya cha Hydrocolloids 2022, n=30)

Mlingo woletsa mayamwidwe a cholesterol: 22% (data ya certification ya GRAS yochokera ku US FDA)

Kuchulukitsa kwa ma SCFA: Kuchuluka kwa acetic acid kumawonjezeka nthawi 3.8 (Gut 2023, Animal Model)

Youdaoplaceholder0 1.2 "Precision feeding" njira ya microbiome

Lamulo la viscosity la polydextrose silimangokhudza kagayidwe ka thupi, komanso limapanga mgwirizano wamphamvu ndi zomera za m'mimba. The mkulu mamasukidwe boma kupanga chotchinga thupi mu proximal colon, kuchepetsa kukhudzana mabakiteriya pathogenic ndi matumbo mucosa. Pamene mamasukidwe akayendedwe amachepetsa, pang'onopang'ono amasintha kukhala fermentable gawo lapansi, makamaka zolimbikitsa kuchulukana kwa Bifidobacteria ndi lactic acid mabakiteriya. Gulu lochokera ku yunivesite ya Cambridge linapeza kudzera mu ndondomeko ya metagenomic kuti kudya kosalekeza kwa 12g/tsiku la polydextrose kwa masabata 8 kungathe kukulitsa chi?erengero cha F/B cha Thick-miliae/Bacteroidetes kufika pa 1.3 (ndi maziko athanzi a 1.5-2.0), ndi kuonjezera kuchuluka kwa mabakiteriya (58%) a butcalium acid (5%). Izi zapawiri-gawo la "chitetezo choyamba, kenako chakudya" chimakwaniritsa zosowa zachilengedwe za magawo osiyanasiyana am'mimba.

?

Youdaoplaceholder0 Chapter 2 Application Scenario Revolution: Kulowa m'malire kuchokera ku Zakudya Zoyendetsedwa ndi Shuga kupita ku ICU Nutrition

Youdaoplaceholder0 2.1 Makampani Azakudya: "Mafupa osawoneka" azinthu za Low GI

Pankhani yophika, kuchuluka kwa madzi (> 8g madzi / g) ndi kukhazikika kwamafuta (kulekerera mpaka 200 ℃) kwa polyglucose kumapangitsa kukhala m'malo mwa sucrose. "Ma cookie a Zero Sugar" omwe adayambitsidwa ndi Meiji Gulu la ku Japan amagwiritsa ntchito polyglucose ngati nsonga yayikulu, amangopeza 1.2g yokha ya ma carbohydrate pa cookie iliyonse, ndipo mawonekedwe ake ndi crisp ndizosiyana ndi zomwe zili ndi shuga. Chofunika koposa, kuwongolera kwake kwamatumbo am'matumbo ang'onoang'ono kumatha kuchedwetsa kuyamwa kwa shuga ndikuchepetsa kuchuluka kwa shuga m'magazi a postprandial ndi 34% (Zachipatala kuchokera ku Diabetes Care 2021).

?

Youdaoplaceholder0 nkhani yatsopano:

?

Youdaoplaceholder0 Nestle : "Smart-release energy bar" yopangidwa pophatikiza polydextrose ndi dextrin yosamva imakhala ndi mawonekedwe a viscosity gradient omwe amakulitsa kuyamwa kwa ma carbohydrate mpaka maola 6, kukwaniritsa zosowa zamphamvu za othamanga marathon.

Youdaoplaceholder0 Nongfu Spring : Anakhazikitsa "M'matumbo Omwe Amakhala Madzi Onyezimira" okhala ndi ma polyglucose owonjezera, omwe amagwiritsa ntchito mphamvu yake yoyatsa kachulukidwe kakang'ono kuti apange mpweya wocheperako m'matumbo kuti upangitse kuphulika kwa matumbo. Adagulitsa mabotolo opitilira 100 miliyoni m'miyezi itatu.

Youdaoplaceholder0 2.2 Zakudya zachipatala: The "intestinal chotchinga Guard" kwa odwala ICU

Kulephera kwa m'mimba mucosal chotchinga mwa odwala kwambiri nthawi zambiri kumayambitsa matenda am'thupi. Kuyesa kosasinthika (n=158) kochitidwa ndi First Affiliated Hospital ku Zhejiang University kunawonetsa kuti odwala ICU omwe amawonjezeredwa ndi 15g ya polyglucose tsiku ndi tsiku anali ndi kuchepa kwa 42% pazochitika za endotoxemia ndi kuchepa kwa 29% kwa intestinal permeability index (plasma ligonin). Njirayi imakhala yakuti dziko lapamwamba kwambiri limapanga filimu yotetezera m'mimba, kuchepetsa chiopsezo cha zilonda zopweteka. Asidi a butyric omwe amatulutsidwa ndi gawo la colonic amalimbikitsa mwachindunji kukulitsa kwa ntchofu wosanjikiza (kuchulukitsa kuchuluka kwa ma cell a goblet ndi 37%), ndikukwaniritsa kulimbitsa kwa zotchinga zakuthupi ndi zamankhwala.

?

Youdaoplaceholder0 Chapter 3 Technological Breakthrough: The Upgrade from 'Empirical Formulas' kupita ku' Computational Nutrition '

Youdaoplaceholder0 3.1 Kuwongolera kolondola kwa kusintha kwa maselo

Mayankho a viscosity osiyanasiyana amtundu wa polydextrose ndi ochepa, zomwe zimapangitsa kuti zikhale zovuta kufananiza ndendende zomwe munthu aliyense amafuna. Mu June 2023, DSM yaku Netherlands idalengeza ukadaulo wake wa "PolySmart?", womwe udapanga mitundu itatu yokhotakhota yokhotakhota powongolera kuchuluka kwa polymerization (DP value) ya shuga ndi sorbitol:

?

Mtundu wa Youdaoplaceholder0 G (kukulitsa m'mimba) : Kuwoneka bwino mpaka 1500 mPa·s pa pH

Mtundu wa Youdaoplaceholder0 C (woyang'aniridwa ndi colon) : Viscosity imatsika kwambiri mpaka 30 mPa·s pa pH> 6.5, yomwe imakonda kwa anthu omwe ali ndi vuto la kudzimbidwa;

Youdaoplaceholder0 Type B ? (mawonekedwe oyenera): Kusintha kosalala kwamatumbo am'mimba, koyenera kuyang'anira shuga wamagazi mwa odwala matenda ashuga.

Youdaoplaceholder0 3.2 AI-Assisted Formulation design

Pulatifomu ya "FiberEngine" yopangidwa ndi kampani yaku Israeli ya NutriAI imaphatikiza ma data a 2 miliyoni a m'matumbo a microbiota ndi mitundu yamadzimadzi, yomwe imatha kuneneratu kuchuluka kwa polydextrose muzaka zosiyanasiyana komanso matenda. Mwachitsanzo, kwa odwala omwe ali ndi IBS (Irritable Bowel syndrome), dongosololi limalimbikitsa kuphatikiza kwa tsiku ndi tsiku kwa 8-10g ya polyglucose ndi 2g ya fructooligosaccharides, zomwe zimachepetsa kuchuluka kwa kutsekula m'mimba ndi 65% (2023 data tracking user).

?

Youdaoplaceholder0 Chaputala 4 Chisokonezo: "Fiber Blue Ocean" yomwe Giants akulimbirana.

Youdaoplaceholder0 4.1 Mpikisano wothamanga ukuwotha

Kukula kwa msika wapadziko lonse wa polydextrose kukuyembekezeka kukula kuchokera pa $ 870 miliyoni yaku US mu 2023 mpaka $ 2.1 biliyoni yaku US mu 2030 (CAGR 12.3%). China yakhala bwalo lalikulu lankhondo.

?

Youdaoplaceholder0 Baolingbao Bio : Ikani ndalama zokwana yuan 500 miliyoni kuti muwonjezere matani 30,000 pachaka, pogwiritsa ntchito enzymatic synthesis process kuti mukwaniritse chiyero cha 99.5%;

Youdaoplaceholder0 Rogate : Ma microcapsules a Probiotic-polyglucose opangidwa mogwirizana ndi CHR. Hansen adachulukitsa kupulumuka kwa asidi mpaka 90%;

Youdaoplaceholder0 Matsuya Chemie, Japan : Anayambitsa "nano-fibrotic polyglucose," yomwe ili ndi mphamvu zochulukirapo katatu ndipo yapatsidwa dzina la mankhwala amasiye ndi FDA pa matenda am'mimba.

Youdaoplaceholder0 4.2 Zovuta zapawiri pakuwongolera ndi kuzindikira

Ngakhale kuti polydextrose yavomerezedwa ngati chakudya chamagulu ndi European Union, China ndi mayiko ena, ogula akadali ndi kusamvana. Kafukufuku wa FMCG ku United States akuwonetsa kuti 28% yokha ya ogula amatha kusiyanitsa molondola kusiyana kwa ntchito pakati pa polydextrose ndi wowuma wosamva. Kuphatikiza apo, kudya kwambiri (kupitirira 50 g / tsiku) kungayambitse matenda am'mimba kapena kusokoneza kuyamwa kwa mchere. Makampaniwa akuyenera kukhazikitsa malangizo ovomerezeka amomwe amayendera.

?

Youdaoplaceholder0 Mutu 5 Kuyang'ana m'tsogolo: "Fiber Network" kuchokera ku GUT kupita ku Body Health

Youdaoplaceholder0 5.1 Umboni watsopano wowongolera axis ya ubongo-m'matumbo

Kumayambiriro kwa chaka cha 2024, bungwe la California Institute of Technology linapeza poyesa mbewa kuti butyric acid yomwe imapangidwa ndi kuwira kwa polydextrose imatha kulimbikitsa ma hypothalamic neurons kudzera mu mitsempha ya vagus, kuchepetsa makhalidwe monga nkhawa ndi 43%. Izi zimapereka tsatanetsatane wazomwe zimati "zakudya zokhala ndi fiber zambiri zimapangitsa kukhala ndi thanzi labwino m'maganizo".

?

Youdaoplaceholder0 5.2 Zosokoneza Zosokoneza mu Synthetic biology

Zymergen yaku US yoyambira idagwiritsa ntchito ukadaulo wa CRISPR kusintha Trichia pastoris, ndikupangitsa kuti itulutse mwachindunji "polyglucose yosinthidwa jini" yokhala ndi makonda opindika amawonekedwe. Chogulitsachi chinawonetsa kuwongolera kwa 80% pakuyankha kwa pH kulondola koyeserera koyeserera kagayidwe ndipo akuyembekezeka kulowa mu gawo la mayeso azachipatala mu 2025.

?

Youdaoplaceholder0 Mapeto: Kufotokozeranso "malire anzeru" a Fiber

Mphamvu ya viscosity gradient ya polydextrose imawonetsa nyengo yatsopano yazakudya zama fiber, kuchoka ku "passive supplementation" kupita ku "malamulo ogwira ntchito". Pamene chigawo cha CHIKWANGWANI chitha kuwongolera ntchito yake molingana ndi momwe matumbo amagwirira ntchito, titha kukhala tikuwona kusintha kwa sayansi yazakudya - mtsogolo mwaumoyo sikudzakhalanso kuyesa kwa molekyulu imodzi, koma kuvina kogwirizana kwa zida zanzeru, ma microbiome, ndi luntha lochita kupanga. Monga momwe wopambana Mphoto ya Nobel mu Chemistry, Frances Arnold, adanenapo kuti, "Mamolekyu m'chilengedwe amakhala ndi mwayi wopanda malire. Zomwe tiyenera kuchita ndikuphunzira kumvera 'chinenero chawo cha nthawi ndi malo'."