1. Ubwino wa kagayidwe kachakudya ndi kuwongolera shuga wamagazi

1. Ziro zopatsa mphamvu ndipo palibe zotsalira za metabolic
Mamolekyu a sucralose atasinthidwa ndi chlorination, dongosolo la m'mimba la munthu silinathe kuwola kukhala shuga wokhoza kuyamwa. Deta yachipatala ikuwonetsa kuti pafupifupi 85% imatulutsidwa mwachindunji kudzera m'matumbo pambuyo pa kumeza, ndipo 15% yotsalayo imapangidwa ndi chiwindi kukhala mankhwala omwe siapoizoni ndipo amachotsedwa mumkodzo 13. Katunduyu amapangitsa kukhala chotsekemera cha "zero calorie", chopanda mphamvu zowonjezera kwa odwala matenda ashuga pamlingo watsiku ndi tsiku wofikira 9mg/kg kulemera kwa thupi ?28.

2. Kukhazikika kwa shuga m'magazi
Palibe kukondoweza kwa insulin : Kafukufuku wa 2024 wopangidwa ndi International Diabetes Federation (IDF) adawonetsa kuti sucralose sinayambitse cholandilira chotsekemera T1R2/T1R3 m'maselo a pancreatic beta ndipo sichinayambitse kutulutsa kwa insulin 57.
Pewani kuyamwa kwa shuga : Mosiyana ndi sucrose, sucralose sisokoneza ntchito ya SGLT1 yonyamula shuga m'matumbo aang'ono, komanso kuyamwa kwa shuga m'matumbo kumakhala koyenera 36. Mwachitsanzo, anthu 50 omwe ali ndi matenda a shuga amtundu wa 2 omwe amamwa zakumwa zokhala ndi sucralose kwa masiku 30 otsatizana anali ndi kusinthasintha kosachepera 0.3% kwa A1c (HbA1c) 5.
Chachiwiri, phindu lenileni la kasamalidwe ka zakudya

1. Kuthekera kosintha shuga wamba
Kutsekemera kwa sucralose ndi kuwirikiza 600 kuposa sucrose, ndipo pang'ono chabe ndizomwe zingakwaniritse zosowa za kukoma. Mwachitsanzo:

Kuonjezera 30mg sucralose ku chakumwa chopanda shuga cha 300ml kumatha kupeza kutsekemera kofanana ndi 10% sucrose solution 16;
Kuonjezera 15mg pa 100g iliyonse ya ufa muzowotcha kumachepetsa kudya kwa sucrose ndi pafupifupi 45g 48.

2. Kukhathamiritsa kwadongosolo lazakudya
Chepetsani kudalira kwa ma carbohydrate : Posintha zakudya zama carbohydrate zachikhalidwe, odwala matenda ashuga amatha kuchepetsa kudya kwazakudya tsiku lililonse ndi 50-80g, zomwe zimafanana ndi kudula 200-320kcal calories 27;
Kukula kosiyanasiyana kwazakudya : Kuchulukitsa kuvomerezedwa kwa zakudya zamtundu wa shuga ndi 40% mwa kulola kudya zakudya zotsekemera kwambiri monga ayisikilimu ndi keke 38.
Chachitatu, kupewa kuopsa kwa thanzi

1. Pewani zovuta za shuga
Amachepetsa chiopsezo cha matenda a mano : Mabakiteriya amkamwa sangathe kuthyola sucralose, ndipo mphamvu zake zotsutsana ndi caries zimachepetsa chiopsezo cha matenda a m'kamwa ndi 27% mwa anthu omwe ali ndi matenda a shuga 46;
Kuteteza dongosolo lamtima: Pambuyo pochotsa sucrose, milingo ya triglyceride ya odwala idatsika ndi avareji ya 0.4mmol/L ndi low-density lipoprotein (LDL) idatsika ndi 12% 78.

2. Kusintha kwa zochitika zapadera
Kukhazikika kwa kutentha kwambiri : pophika pansi pa 120 ℃, sucralose sipanga zinthu zapoizoni monga chloropropanol, yomwe ndi yoyenera kupanga makeke opanda shuga 38;
Kugwirizana kwa mankhwala : alibe kugwirizana ndi mankhwala omwe amagwiritsidwa ntchito nthawi zambiri a hypoglycemic monga metformin ndi insulin, koma ayenera kumwedwa ndi anticoagulant mankhwala monga warfarin 27 pakadutsa maola awiri.
Chachinayi, ubwino wamaganizo ndi chikhalidwe cha anthu

1. Kukhala ndi moyo wabwino
Odwala matenda a shuga adachepetsedwa ndi 62% kupsinjika kwamaganizidwe chifukwa chosowa chokoma komanso kutsika kwapakati kwa 3.2 pa Depression Scale (PHQ-9) 68. Kafukufuku wa 2024 wa Consumer adawonetsa kuti kukhutitsidwa kwazakudya pakati pa odwala matenda ashuga omwe amagwiritsa ntchito sucralose m'malo mwa shuga kudakwera kuchoka pa 43% mpaka 79%3.

2. Kukhathamiritsa kwachuma kwachuma
Kuchepetsa ndalama zachipatala : kungachepetse mtengo wamankhwala wapachaka wa matenda a shuga, retinopathy ndi zovuta zina za 3200 yuan/munthu 78;
Zatsopano zamakampani azakudya : Limbikitsani msika wazakudya wopanda shuga kuti ukule ndi 18% pachaka ndipo akuyembekezeka kufika 120 biliyoni yuan 14 mu 2025.

5. Mafotokozedwe a ntchito ndi ziyembekezo zamtsogolo

1. Mfundo zogwiritsira ntchito sayansi
Kuwongolera Mlingo : Tsatirani mlingo wapamwamba wa WHO wa 9mg/kg kulemera kwa thupi tsiku lililonse (pafupifupi 540mg kwa akuluakulu 60kg) 28;
Kusankha kwa njira : Zopangira ukadaulo wa microencapsulation zidakondedwa kuti zichepetse kukhudzidwa kwa m'matumbo (kutsika kwa bifidobacterium kunachepetsedwa kuchoka pa 30% mpaka 8%) 18.

2. Njira yachitukuko chaukadaulo
Ukadaulo wowongolera molondola : Njira ya "directed chlorination" yomwe idapangidwa ndi Jinhe Industry mu 2025 imachepetsa kuchuluka kwa chloropropanol kufika pa 0.01ppm8;
Kafukufuku wachipatala wozikidwa pa umboni : International Diabetes Association yakhazikitsa kafukufuku wamagulu a anthu 100,000 kuti awone zotsatira za nthawi yayitali za sucralose pa islet function 56.
mapeto
Sucralose imapatsa odwala matenda a shuga yankho lomwe limalinganiza zosowa za kukoma ndi kasamalidwe kaumoyo. Miyezo yake yayikulu imaphatikizidwa mu inertia ya metabolic, kukhazikika kwa glucose m'magazi komanso kupewa zovuta. Ndi njira zopangira zotsogola (monga ukadaulo wa microencapsulation) komanso machitidwe owongolera (monga kusinthidwanso kwa Nutrition Labeling Guidelines for Pre-Packaged Foods mu 2025), sucralose idzakhala chida chotetezeka komanso chachangu pakuwongolera zakudya za shuga. Komabe, ziyenera kutsindika kuti cholowa m'malo mwa shuga sichingalowe m'malo mwa zakudya zopatsa thanzi komanso kuchita masewera olimbitsa thupi, ndipo kugwiritsa ntchito kwasayansi kuyenera kutsatiridwa ndi malangizo azachipatala payekhapayekha.