Tiyi ndi zakumwa zotchuka kwambiri padziko lonse lapansi, makamaka ku China. Tiyi ku China si chakumwa chokha, komanso chizindikiro cha moyo ndi chikhalidwe.

Kumwa tiyi kumaonedwa kuti ndi chizolowezi chokhala ndi moyo wathanzi chifukwa tiyi imakhala ndi mankhwala osiyanasiyana opindulitsa, monga makatekini, tiyi polyphenols ndi caffeine. Kafukufuku wambiri wasonyeza kuti Tingafinye tiyi akhoza ziletsa khansa, kutalikitsa moyo, kuchepetsa chiopsezo cha kuthamanga kwa magazi, shuga, matenda a mtima ndi zina zotero.

Matenda a chiwindi osaledzeretsa (NAFLD) ndi mtundu wofala kwambiri wa matenda a chiwindi ku China, omwe ali ndi odwala oposa 150 miliyoni. Pakalipano, palibe mankhwala omwe amavomerezedwa kuti athetse matenda a chiwindi chamafuta osaledzeretsa, ndipo odwala amatha kulowererapo ndi kusintha kwa zakudya ndi masewera olimbitsa thupi. Choncho, pali kufunikira kofulumira kupanga njira zatsopano zothandizira.

Posachedwapa, Ofufuza ochokera ku China Medical University adasindikiza pepala lotchedwa "Epigallocatechin gallate imachepetsa matenda a chiwindi chamafuta osaledzeretsa" m'magazini ya Clinical Nutrition kudzera mu kuletsa kwa mawu ndi ntchito za Dipeptide kinase 4 ".

Kafukufukuyu adatsimikizira kudzera m'mayesero oyendetsedwa mwachisawawa, kuyesa kwanyama komanso kuyesa kwa in vitro kuti EGCG, chinthu chachikulu cha bioactive mu tiyi wobiriwira, imathandizira kukonza chiwindi chamafuta, ECGC imalepheretsa kuchulukira kwa lipid, imalepheretsa kutupa, imayang'anira kagayidwe ka lipid, imalepheretsa kuwonongeka kwa chiwindi, komanso imapangitsa kuti chiwongolero chamafuta osaledzeretsa chiwonjezeke ndi ntchito ya pedyseptide. (DPP4).

Dipeptide kinase 4 (DPP4), protease yomwe imadula magawo angapo pamtunda wa selo, yakhala ikusonkhanitsa umboni wosonyeza kuti DPP4 imathandizira pa chitukuko cha NAFLD, odwala NAFLD akuwonetsa ntchito yapamwamba ya plasma DPP4 poyerekeza ndi anthu athanzi.

Mu phunziro ili, ochita kafukufuku adafufuza momwe EGCG ingathere kwa odwala omwe ali ndi NAFLD kudzera m'mayesero osadziwika bwino, adawona kusintha kwa EGCG pa chiwindi cha mbewa zachitsanzo kupyolera mu kuyesa kwachitsanzo cha zinyama, ndikuwunika momwe EGCG ikuyendera mu NAFLD kupyolera mu mayesero a vitro.

M'mayesero achipatala opangidwa mwachisawawa okhudza anthu a 15 omwe ali ndi NAFLD, EGCG inkagwiritsidwa ntchito ndi mapiritsi a tiyi a polyphenol, ndipo deta ya chiwindi inayesedwa poyambira, masabata a 12, ndi masabata a 24.

Zotsatirazo zinapeza kuti odwala anali ndi mafuta ochepa kwambiri a chiwindi pambuyo pa masabata a 24 a chithandizo cha EGCG poyerekeza ndi chiyambi, ndipo awiri mwa odwalawo anali ndi chikhululukiro cha chiwindi chamafuta pambuyo pa kutha kwa nthawi ya chithandizo cha 24 sabata. Kuphatikiza apo, kuchuluka kwa m'chiuno mwa odwala komanso kuchuluka kwa cholesterol chonse kumatsikanso kwambiri pakadutsa milungu 24.

Kusanthula kunawonetsa kuti pambuyo pa masabata a 24 a chithandizo cha EGCG, miyeso ya AST idachepetsedwa ndipo ma DPP4 adachepetsedwanso.

Kusanthula kwa aimpso kunawonetsa kuti milingo ya creatinine mu seramu ndi kusefera kwa glomerular zakhalabe mkati mwanthawi zonse, zomwe zikuwonetsa kuti EGCG ili ndi mbiri yabwino yachitetezo.