Kuthekera kwa mannose m'munda wamankhwala kumakhazikika m'njira zingapo, zina zomwe zidagwiritsidwa ntchito kale (monga kupewa matenda a mkodzo), pomwe ena ali mu kafukufuku woyambira kapena siteji yoyeserera yachipatala. Zoyembekezazo ndizoyenera kuziganizira, koma umboni wochulukirapo ukufunika kuti uwathandize. Fotokozani kuthekera kwake m'mbali zotsatirazi:

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1, Magawo Odziwika / Okhwima Ogwiritsa Ntchito

Kupewa matenda a mkodzo (rUTI) ?

Njira: Kugwiritsa ntchito pakamwa kwa mannose kumapangitsa kuti mkodzo utuluke kwambiri, kutsekereza zomatira za FimH pilin kuchokera ku tizilombo toyambitsa matenda monga Escherichia coli kupita ku ma cell epithelial a chikhodzodzo, kuletsa mabakiteriya kulowa m'mikodzo ndikutsukidwa ndi mkodzo.

Umboni:

Maphunziro angapo azachipatala, monga kuyerekeza ndi furantoin yolimbana ndi maantibayotiki, awonetsa kuti 1.5-2g ya mannose patsiku ndi yothandiza ngati maantibayotiki ochepa popewa rUTI yoyambitsidwa ndi Escherichia coli mwa amayi, ndipo ali ndi chiopsezo chochepa chokana.

Maupangiri a European Association of Urology (EAU) amawalemba ngati njira ina yopewera rUTI (Level of Evidence: B).

Ubwino wake: Kutetezedwa kwakukulu (zotsatira zochepa za m'mimba), palibe chiopsezo chokana maantibayotiki ambiri.

Zolepheretsa: Zimagwira ntchito popewera ndipo sizingalowe m'malo mwa maantibayotiki pochiza matenda oopsa; Zotsatira za non Escherichia coli UTI ndizochepa.

2, Madera omwe ali mu gawo la kafukufuku koma omveka bwino

Chithandizo cha Congenital Glycation Disorder (CDG)

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Njira: Mitundu ina ya CDG, monga MPI-CDG (mtundu wa CDG-Ib), ilibe phosphomannose isomerase (PMI), yomwe imalepheretsa kutembenuka kwa mannose-6-phosphate kukhala fructose-6-phosphate, zomwe zimayambitsa kulephera kwa ziwalo zambiri.

Chithandizo: Kuwongolera pakamwa kwa mannose kumatha kulambalala zolakwika za PMI ndikupereka mwachindunji mannose-6-phosphate, kubwezeretsa kaphatikizidwe ka glycoprotein.

Zomwe zikuchitika pano:

A FDA avomereza kugwiritsa ntchito mannose kwa MPI-CDG, yomwe ndi imodzi mwazinthu zochepa zochiritsira za CDG.

Kuwongoka kwakukulu kwa matenda a chiwindi, kusagwira bwino ntchito kwa m'mimba, ndi zizindikiro za m'mimba, koma mankhwala amoyo wonse amafunikira.

Kuthekera: Onani mtengo wachirengedwe wa adjuvant wa ma CDG ena, monga ALG-CDG.

Antitumor immune regulation and delivery drug ???? (Kafukufuku waposachedwa wamankhwala)

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Njira:

Chotupa chodziwika bwino cha microenvironment: Chotupa chogwirizana ndi macrophages (TAMs) chimawonetsa kwambiri mannose receptors (MRC1), ndipo mankhwala osinthidwa a mannose amatha kuperekedwa ku zotupa m'njira yolunjika.

Kuwongolera kuponderezedwa kwa chitetezo chamthupi: Mannose mopikisana amalepheretsa zolandilira za mannose pamwamba pa ma TAM, kutsekereza kuzindikira kwawo kwa mannose glycated antigens pamwamba pa maselo otupa, omwe amatha kusintha kuponderezana kwa chitetezo chamthupi.

Kupititsa patsogolo mphamvu ya mankhwala amphamvu amphamvu: M'maphunziro a nyama, kuphatikiza kwa mannose ndi chemotherapy (monga doxorubicin) kumatha kulepheretsa kukula kwa chotupa (mwina mwa kusokoneza kagayidwe ka shuga).

Chovuta: Kafukufuku wowonjezereka akufunika pakuchita bwino kwa anthu, mlingo woyenera, ndi machitidwe operekera.

Antifungal/antiparasite matenda adjuvants ??

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Njira: Tizilombo toyambitsa matenda monga Candida albicans ndi Plasmodium timadalira zolandilira mannose kuti zilowe m'maselo. Mannose amatha kuletsa kumamatira kwake.

Kafukufuku:

Zitsanzo za in vitro ndi zinyama zasonyeza kuti mannose amatha kulepheretsa Candida kumamatira ku maselo a epithelial.

Kugwiritsiridwa ntchito limodzi ndi mankhwala oletsa malungo kungachepetse kufala kwa tizilombo ta malungo (kuyesa kwa zinyama).

Kuthekera: Monga chothandizira kupititsa patsogolo mphamvu za mankhwala omwe alipo kale komanso kuchepetsa kukana kwa mankhwala.

3, mayendedwe owunikira omwe akutuluka (angathe kutsimikiziridwa)

Matenda otupa a m'matumbo (IBD) komanso kukonza m'mimba ??

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Lingaliro:

Mannose amatha kuwongolera matumbo a microbiota (kulimbikitsa mabakiteriya opindulitsa) ndikuletsa kumamatira kwa bakiteriya.

Limbikitsani ntchito ya m'matumbo mucosal chotchinga mapuloteni kudzera glycosylation kusintha.

Zomwe zikuchitika pano: Zitsanzo za nyama (colitis) zikuwonetsa zoteteza, koma kafukufuku wamunthu akusowa.

Kuwongolera matenda a autoimmune ??

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Chiphunzitso: Glycosylation yachilendo imakhudzidwa ndi matenda a nyamakazi, lupus, ndi matenda ena. Mannose supplementation imatha kukonza zolakwika za glycosylation.

Kupita patsogolo: Kungowonedwa m'maselo a maselo kapena milandu yochepa kwambiri, popanda mayesero okhwima azachipatala.

Kupewa zovuta za matenda a shuga ??

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Zomveka: Shuga wokwera m'magazi kumabweretsa kuchulukirachulukira kwa ma non enzymatic glycation (AGEs) a mapuloteni, zomwe zimayambitsa zovuta. Kagayidwe ka mannose sikudalira insulini ndipo sikumakhudza shuga wamagazi, kapena kumatha kuchepetsa mapangidwe a AGE.

Umboni: Zoyeserera zanyama zikuwonetsa kuti kupita patsogolo kwa matenda a shuga nephropathy kumachepa, ndipo kafukufuku wamunthu alibe.

4. Zovuta ndi zolephera

Zovuta zazikulu m'munda

Kupewa kwa UTI sikungatheke polimbana ndi matenda omwe si Escherichia coli; Chitetezo chanthawi yayitali sichikwanira (makamaka ntchito yaimpso)

Chithandizo cha CDG chimangogwira ntchito pamagulu apadera; Kuzindikira msanga ndi mankhwala amoyo wonse ndikofunikira

Mphamvu ya chithandizo cha chotupa m'thupi la munthu sichidziwika; Mlingo waukulu ungayambitse kutsekula m'mimba; Chiwopsezo chakupha chophatikiza chemotherapy chiyenera kuwunikiridwa

Kusakwanira kokwanira kwa kugwiritsidwa ntchito kamodzi kwa anti infective adjuvants; M`pofunika konza osakaniza mankhwala ndi alipo mankhwala

Kafukufuku wofooka pamakina azinthu zina zomwe zikubwera; Kupanda mayeso apamwamba azachipatala; Ambiri a iwo amakhalabe mu siteji yachitsanzo cha zinyama

5, Chitukuko chamtsogolo

Kupititsa patsogolo kachitidwe kachitidwe kakulondola: Kupanga mannose osinthidwa ma nanocarriers kuti apititse patsogolo chotupa / chotupa choyambitsa matenda.

Kukhathamiritsa kwamankhwala ophatikizika: kuwunika momwe mannose amagwirira ntchito ndi maantibayotiki, ma immune checkpoint inhibitors, ndi antifungal mankhwala.

Kukula kwa Matenda Osowa: Kuwunika kwa ma CDG ochulukirapo komanso zovuta zosungirako za lysosomal zomwe zitha kuthandizidwa ndi mannose.

Kukonzekera kokhazikika kokhazikika: kumathetsa vuto la kumwa mankhwala pafupipafupi (monga kugwiritsa ntchito tsiku lililonse kupewa UTI).

Population stratification strategy: mankhwala olondola otengera mtundu wa pathogen (UTI) kapena gene mutation (CDG)