Vitamini B3, yomwe imadziwikanso kuti niacin, ndi vitamini yosungunuka m'madzi yomwe imagwira ntchito zosiyanasiyana zofunika m'thupi. Kafukufuku woyambirira awonetsa kuti vitamini B3 imatenga nawo gawo mu metabolism yamphamvu ya thupi, imalimbikitsa kagayidwe ka maselo a khungu, komanso imakhala ndi antioxidant.

Non-alcoholic mafuta chiwindi matenda (NAFLD), ndi chiwerengero chachikulu cha matenda aakulu chiwindi mtundu China, pali oposa 150 miliyoni odwala China, amene 10-20% adzapitiriza kukhala sanali mowa steatohepatitis (NASH), makamaka kuwonetseredwa ndi kutupa ndi kuwonongeka kwa chiwindi maselo, nthawi zambiri limodzi ndi fibrosis. NASH imapita patsogolo mofulumira ndipo imakhala ndi chiopsezo chachikulu chokhala ndi matenda aakulu a chiwindi monga cirrhosis ndi khansa ya chiwindi.

Posachedwapa, Ofufuza ochokera ku Sukulu ya Health Public ku Sun Yat-sen University adasindikiza pepala m'magazini ya JAMA Network Open yotchedwa "Dietary Niacin Intake and Mortality among Individuals With Nonalcoholic. Matenda a Chiwindi Chamafuta "kafukufuku.

Kafukufukuyu adawonetsa kuti kuphatikizika ndi vitamini B3, kapena kuchepetsa chiopsezo cha kufa kwa odwala omwe ali ndi vuto la chiwindi chamafuta osaledzeretsa, kumalumikizidwa ndi kutsika kwa 30% pachiwopsezo cha kufa chifukwa cha zonse mwa omwe adatenga nawo gawo (≥26.7mg / tsiku) poyerekeza ndi omwe adatenga nawo gawo lotsika kwambiri latsiku 18.4mg.

Mu phunziro ili, ochita kafukufuku adafufuza mgwirizano pakati pa kudya kwa vitamini B3 ndi chiopsezo cha imfa zonse kwa odwala omwe ali ndi matenda a chiwindi chamafuta osamwa mowa mwa kusonkhanitsa zakudya za vitamini B3 kuchokera ku National Health and Nutrition Examination Survey (NHANES) ya 4,315 NAFLD odwala omwe ali ndi zaka zapakati pa 53.

Ophunzirawo adagawidwa m'magulu atatu malinga ndi kudya kwa vitamini B3: gulu lochepa (≤18.4mg / tsiku), gulu lapakati (18.5-26.6mg / tsiku) ndi gulu lalikulu (≥26.7mg / tsiku).
Pakati pa nthawi yotsatizana ya zaka 8.8, chiwerengero cha imfa za 566 zinalembedwa, 197 mwa zomwe zimatchedwa matenda a mtima.

Kuwunikaku kunapeza kuti omwe adatenga nawo gawo omwe amadya kwambiri anali ndi chiwopsezo chochepa cha 30 peresenti ya kufa chifukwa cha zonse poyerekeza ndi omwe amadya kwambiri.

Kuphatikiza apo, otenga nawo gawo omwe amadya kwambiri adachepetsa ndi 35 peresenti pachiwopsezo cha kufa kwamtima, koma izi sizinali zofunikira.

Kufufuza kwina kunapeza kuyanjana kwakukulu pakati pa kudya kwa vitamini B3 ndi chiopsezo cha matenda a shuga ndi imfa zonse, ndikuchepetsa kwambiri imfa kwa odwala omwe alibe matenda a shuga poyerekeza ndi omwe ali ndi matenda a shuga.

Malinga ndi ofufuzawo, niacin ndi imodzi mwazomwe zimayambira pa kaphatikizidwe ka NAD ndipo yakhala chandamale chofunikira popewa komanso kuchiza matenda a chiwindi. Kafukufuku wokhudza anthu awonetsanso kuti niacin imatha kusintha chiwindi chamafuta ndikuchepetsa mafuta a chiwindi. M'maphunziro a preclinical, niacin yapezeka kuti imaletsa ndikusintha chiwindi steatosis ndi kutupa, ndikuletsa fibrosis. Zotsatirazi zimatheka mwa kuchepetsa kupsinjika kwa okosijeni, kuletsa diacylglyceryl acyltransferase 2 ndi NADPH oxidase ntchito, ndi njira zina zomwe zingatheke.

Ndikoyenera kunena kuti mu Seputembala 2023, Ofufuza ochokera ku Sukulu ya Zaumoyo Pagulu ku Yunivesite ya Sun Yat-sen adasindikiza pepala m'nyuzipepala ya Nutrients yotchedwa "Mgwirizano pakati pa Zakudya za Niacin Intake ndi Matenda a Chiwindi Chopanda Mowa: NHANES 2003-2018 "pepala lofufuza.

Kafukufukuyu adawonetsa kuti vitamini B3 supplementation idalumikizidwa ndi chiwopsezo chochepa cha matenda a chiwindi chamafuta osaledzeretsa, omwe ali ndi vuto lalikulu la niacin (≥29.2mg / tsiku) okhala ndi chiopsezo chochepa cha 31% cha matenda a chiwindi chamafuta osaledzeretsa poyerekeza ndi omwe ali ndi niacin yotsika kwambiri (≤16.3mg / tsiku).

Kutengera pamodzi, zotsatira zake zimasonyeza kuti vitamini B3 yowonjezera imagwirizanitsidwa ndi chiopsezo chochepa cha matenda a chiwindi chamafuta osaledzeretsa komanso kuchepetsa chiopsezo cha imfa kwa odwala omwe ali ndi matenda a chiwindi omwe si oledzera. Kafukufuku wowonjezereka akufunika kuti atsimikizire mlingo woyenera wa vitamini B3 kuti achepetse chiopsezo cha imfa zonse kwa odwala omwe ali ndi NAFLD.