Matenda a chiwindi cha mowa (ALD), omwe ndi matenda a chiwindi omwe amayamba chifukwa cha kuledzera kwa nthawi yaitali, ndi amodzi mwa matenda a chiwindi omwe amapezeka ku China, kuphatikizapo chiwindi chamafuta oledzeretsa, matenda a chiwindi a mowa, mowa woledzeretsa ndi matenda a cirrhosis. M'zaka zaposachedwa, kufalikira kwa matenda a chiwindi chauchidakwa kwawonetsa kuchulukirachulukira ku China.

Pa Julayi 2, 2024, Liu Zhihua wa ku yunivesite ya Tsinghua, Wang Hua wa ku Anhui Medical University, Yin Shi wa University of Science and Technology of China ndi ofufuza ena adafalitsa nkhani ya mutu wakuti "Dietary fiber alleviates chiwindi kuvulala kudzera" mu nyuzipepala Cell Host & Microbe "Bacteroides acidifacification ammonia subspeciation".

Chakudya chokhala ndi ulusi wosungunuka wamafuta chinapezeka kuti chimawonjezera kuchuluka kwa B. accidifaciens ndikuchepetsa kuvulala kwachiwindi kwa mbewa.

Pa makina, B.accifaciens amawongolera kagayidwe ka bile acid kudzera mu bile saline hydrolysis enzyme (BSH). Kuwonjezeka kwa asidi osamangira bile kumayambitsa njira ya FXR-FGF15 m'matumbo, kumateteza matumbo otchinga m'mimba, kumalimbikitsa kufotokozera kwa ornithine aminotransferase (OAT) mu hepatocytes, motero kumalimbikitsa kagayidwe ka ornithine wochuluka mu chiwindi kuti glutamate. Perekani zipangizo zowonongeka kwa chiwindi ndikuchepetsa kuwonongeka kwa maselo a chiwindi.

phunziro ili, ochita kafukufuku anayamba kuyambitsa matenda a chiwindi chauchidakwa mu chitsanzo cha mbewa ndikuwunika zotsatira za ulusi wa zakudya pa matenda a chiwindi chauchidakwa mu mbewa powonjezera zitsulo zonse zosungunuka ndi zosasungunuka.

Zotsatirazo zinapeza kuti kusungunuka kwa zakudya zowonjezera zakudya kumapangitsa kuti matenda a chiwindi asungunuke kwambiri mu mbewa, kuphatikizapo kuchepetsa chiwindi cha steatosis ndi kuchepetsa chiwerengero ndi chiwerengero chonse cha chiwindi cha neutrophils, pamene ulusi wosasungunuka wa zakudya unalibe zotsatira zazikulu.

Chifukwa ulusi wazakudya ukhoza kukhudza kwambiri matumbo a microbiota, ofufuzawo adawunikanso ngati kusintha kwa matenda a chiwindi cha mowa kudachitika chifukwa cha matumbo a microbiota kudzera munjira zosinthira ma microbiota.

Pambuyo pa kumuika, zinapezeka kuti kuika microflora ya mbewa kudyetsedwa soluble fiber fiber kunachepetsa serum alanine aminotransferase (ALT) ndi aspartate aminotransferase (AST) milingo, pamene kuchepetsa chiwindi steatosis ndi kutupa, kutanthauza kuti soluble zakudya CHIKWANGWANI angakhudze chitukuko cha ALD mwa kukonzanso kapangidwe ka matumbo microflora.

Kafukufukuyu adawonetsa kuti ulusi wosungunuka wamafuta umapangitsa kuti chiwindi chiziyenda bwino, chiwopsezo cha chiwindi ndi kutupa mumtundu wa mbewa wa matenda a chiwindi chauchidakwa, komanso kuchepetsa kuchuluka kwa ammonia m'magazi ndi kupsinjika kwa okosijeni, ndikuwunikira gawo lofunikira la ulusi wosungunuka wazakudya popewa komanso kuchiza matenda a chiwindi.

Ndikofunikira kudziwa kuti akuluakulu amalangizidwa kuti azidya magalamu 25-30 kapena kupitilira apo patsiku, koma anthu ambiri samakumana ndi malingaliro azakudya. Mbewu zonse, zipatso ndi ndiwo zamasamba ndizomwe zimakhala ndi ulusi wambiri m'zakudya ndipo zimatha kupereka ma micronutrients ena ofunikira.

Mwachidule, zotsatira zake zimasonyeza kuti zakudya zokhala ndi zitsulo zosungunuka zimatha kusintha kuvulala kwa chiwindi chifukwa cha mowa mu zitsanzo za mbewa ndikuteteza kukhulupirika kwa matumbo. Kafukufukuyu ali ndi phindu linalake lachipatala komanso kufunika kwa chikhalidwe.

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