Njira yachikhalidwe yopanga inositol ndi pressure hydrolysis. Chifukwa cha zaka zambiri zakupanga mafakitale, njira ya hydrolysis ndiyo njira yopangira ukadaulo wotengedwa ndi opanga zoweta ndipo yakhala ikuwongolera mosalekeza. Njira yowonjezera ya kuthamanga kwa hydrolysis ili motere: phytin (hydrolysis) → hydrolysis solution (neutralization, filtration) → yankho la inositol (kuchotsa zonyansa ndi kuika maganizo, crystallization centrifugation) → yaiwisi inositol (kusungunuka ndi kuchotsedwa, crystallization centrifugation) → mankhwala abwino. Pakati pawo, hydrolysis ndi kuyenga ndi njira ziwiri zofunika.
Sodium phytate hydrolysis
Pogwiritsa ntchito madzi a chimanga oviikidwa ngati zopangira, sodium phytate imapangidwa ndi njira ya ion exchange resin adsorption, ndiyeno imakhudzidwa ndi hydrolysis reaction kuti ipange inositol. Panthawi imodzimodziyo popanga inositol, kupanga disodium hydrogen phosphate (kupanga disodium hydrogen phosphate pafupifupi nthawi 12 kuposa inositol) kumatulutsa phosphorous kuchokera kumbewu, ndikutsegula njira yatsopano yobwezeretsanso organic phosphorous muzaulimi ndi zinthu zam'mbali.
Mafotokozedwe a njira yopangira: Madzi akuwunikidwa a chimanga amalowetsedwa ndi utomoni wosinthana ndi ayoni kuti apeze yankho la sodium phytate, lomwe limakhudzidwa ndi kukakamizidwa kwa hydrolysis kuti apange inositol ndi disodium hydrogen phosphate. Pambuyo pa nthawi yochitapo kanthu, zinthuzo zimatulutsidwa, kusefa, kuzimitsa, ndikuwunikiridwa, zomwe zimapangitsa kuti makristasi a disodium hydrogen phosphate agwe. Njira ya hydrolysis reaction ya sodium dihydrogen phosphate makhiristo imayengedwa motsatizana kudzera mu anion ndi cation exchange resins mpaka ndende ya anions ndi cations mu hydrolysis reaction solution ifika pamlingo womwe watchulidwa. The woyengeka hydrolysis anachita njira akhoza anaikira ndi crystallized kupeza yomalizidwa mankhwala inositol. Zokolola za inositol zimakhudzidwa makamaka ndi zinthu zitatu: nthawi ya hydrolysis reaction, hydrolysis reaction pressure, ndi ndende ya sodium phytate solution. Kupyolera mu kuyesa kwa orthogonal, momwe mulingo woyenera kwambiri wa hydrolysis amachitira anapezedwa motere: nthawi ya hydrolysis ya maola 7-8, ndende ya sodium phytate ya 20%, kuthamanga kwa hydrolysis kwa 1.5 MPa, ndi zokolola zambiri za inositol kuyambira 0.1544% mpaka 0.1722%. Kuti muwone kukulitsa mphamvu ya hydrolysis riyakitala, kutsekeka kwa bedi mu nsanja ya ion kuwombola mafakitale, kusintha kwa kusinthana, ndikutsanzira mikhalidwe yayikulu yozungulira yomwe imagwiritsidwa ntchito pakusinthika kwa zida zamafakitale, kuyesa koyesa kunachitika pa chipangizo chokhala ndi mphamvu yopitilira 600m/a pansi pazomwe zili pamwambapa. Zokolola zambiri za inositol ndi 0.1601% (zoposa 2.5 nthawi zambiri kuposa njira ya calcium phytate, ndipo khalidwe la mankhwala limakumana ndi zizindikiro zosiyanasiyana zomwe zafotokozedwa mu National Pharmacopoeia), zomwe zimagwirizana ndi deta yaing'ono yoyesera.
Atmospheric pressure catalytic njira
The atmospheric pressure catalytic method ndi njira yatsopano yopangira inositol yomwe yangopangidwa kumene ndikuyikidwa mu mafakitale ku China m'zaka zaposachedwa. Hydrolysis ndi kuyenga kwake kumakhala ndi mawonekedwe apadera. Zofunikira:
(1) Amachepetsa kwambiri ndalama zogwiritsira ntchito nthawi imodzi, ndipo akhoza kupulumutsa ndalama zoposa 50% za ndalama pamene sikelo ndi yofanana;
(2) Kugwiritsa ntchito phytin hydrolysis chothandizira kufupikitsa nthawi yopanga ndikuwongolera kuchuluka kwa kagwiritsidwe ntchito kazinthu zopangira;
(3) Njira yoyeretsera yasinthidwa, zomwe zimapangitsa kuwonjezeka kwa khalidwe la mankhwala ndi zokolola.
Njira yothandizira mpweya wa mumlengalenga: Gawo lina la chothandizira (lopangidwa ndi glycerol, urea, ndi calcium carbonate) limawonjezeredwa ku phytin solution pamlengalenga, ndikutenthedwa kuti hydrolysis. Pambuyo pa hydrolysis, kusefera, crystallization, kuyanika, ndi njira zina, inositol imatha kupezeka. Chifukwa cha chibadwa cha chothandizira, inositol imatha kusinthidwa nthawi imodzi, zomwe zimapangitsa kuti pakhale zinthu zomalizidwa kwambiri komanso kufewetsa ndondomekoyi. Ma catalysts amatha kubwezeretsedwanso.