Khansara ya Prostate (PC), imodzi mwa khansa yofala kwambiri mwa amuna, imakhala ngati wakupha mwakachetechete, odwala ambiri akukumana ndi zizindikiro zoyamba pang'onopang'ono za matendawa zomwe zimatha kukhala khansa yowopsya. Pakadali pano, khansa ya prostate imatha kukhala yosasinthika kotero kuti njira zonse zochiritsira zomwe zilipo sizikuyankha.

Mwambiwu umati, chithandizocho chimadalira "mfundo zitatu za mankhwala, mfundo zisanu ndi ziwiri zosamalira", "kukonza" uku nthawi zambiri kumatanthauza chakudya chopatsa thanzi. Khansara ya Prostate ndi matenda omwe amapita patsogolo kwa nthawi yayitali. Ngati njira zoyenera zochitirapo kanthu, monga moyo wololera ndi zakudya, zitha kutengedwa kumayambiriro kwa matendawa, zitha kuchedwetsa kupitilira kwa khansa ya prostate ndikupangitsa kuti odwala athe kudziwa bwino.

Pa Okutobala 25, 2024, gulu la Pulofesa Lloyd Trotman wa Cold Spring Harbor Laboratory lofalitsidwa mu nyuzipepala yapamwamba yapadziko lonse yamaphunziro Science yotchedwa: Dietary pro-oxidant therapy ndi vitamin K precursor ikufuna PI 3-kinase VPS34 function Research paper.

Kafukufuku wapeza kuti chowonjezera cha pro-oxidant, menadione (vitamini K3), chingathe kuchepetsa kukula kwa khansa ya prostate. Menadione ndi kalambulabwalo wosungunuka m'madzi wa vitamini K, yemwe nthawi zambiri amapezeka m'masamba obiriwira, ndipo ntchito yake yokhudzana ndi thupi makamaka imalimbikitsa kutsekeka kwa magazi komanso kutenga nawo gawo pakupanga mafupa.

Kafukufuku wamakina awonetsa kuti VPS34 ndi chandamale chachikulu cha phosphatidylinositol 3-kinase (PI3K), menadione imatha kuletsa ntchito ya VPS34, kuchepetsa kupanga PI3P, ndikuwonjezera kupsinjika kwa okosijeni komwe kumayambitsa kufa kwa maselo a khansa ya prostate. Mosiyana ndi izi, maselo abwinobwino amakula pang'onopang'ono motero amakhala ndi mphamvu zokwanira zotha kupirira kuwonongeka kumeneku. Kuphatikiza apo, gulu lofufuza lidawonetsa kuti menadione ilinso ndi chithandizo chamankhwala pamavuto owopsa amtundu wotchedwa X-linked myotubulin myopathy (XLMTM).

Zomwe zapezazi zikuwonetsa njira yosavuta koma yothandiza yothanirana ndi khansa komanso kukhala ndi zotsatirapo zatsopano zochizira matenda ena obadwa nawo omwe amayamba chifukwa cha kusokonekera kwa ntchito ya kinase.

Gululo linachitira zitsanzo za mbewa za RapidCaP ndi pro-oxidant supplement, menadione sodium sulfite (MSB), chigawo chomwe chimakhala chotsatira cha mammalian kwa vitamini K. Iwo adapeza kuti tsiku lililonse la MSB m'madzi akumwa likhoza kulepheretsa kukula kwa khansa ya prostate ndi kupanga choletsa chokhalitsa.

Ponseponse, kafukufukuyu, wofalitsidwa mu Science, akuwonetsa kuti kuwonjezera ma pro-oxidant supplements pazakudya kuti awonjezere MSB kumatha kuchedwetsa kufalikira kwa khansa ya prostate. Izi ndichifukwa choti MSB imatha kuletsa ntchito ya PI3K kinase VPS34, kuchepetsa kupanga PI3P, ndikuwonjezera kupsinjika kwa okosijeni, komwe kumayambitsa kufa kwa ma cell a khansa ya prostate. Kuonjezera apo, mu X-linked myotubular myopathy (XLMTM), MSB ikhoza kuletsa ntchito ya kinase ya VPS34, kubwezeretsa PI3P kumagulu omwe angapangitse kukula kwa minofu.