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Magulu a Nkhani
    Nkhani Zowonetsedwa

    Chifukwa chiyani mannitol amagwira ntchito pa matenda amkodzo

    2025-03-13

    2. Mannose (kapena D-Mannose) ndi shuga wosavuta, koma mosiyana ndi shuga, mannose samatengedwa mosavuta ndi thupi atatha kudya, ndipo 90% ya mannose imatulutsidwa mwachindunji kudzera mumkodzo pambuyo pa mphindi 30 mpaka 60 mutatha kumwa, kotero mosiyana ndi shuga, mannose samakhudza shuga wa magazi, koma amakhazikika kwambiri mumkodzo. Mannose amatha kusokoneza kagayidwe ka shuga, kulepheretsa kuyika kwamafuta, kuwongolera m'matumbo komanso kutenga nawo gawo pakuwongolera chitetezo chathupi. Kumvetsetsa bwino momwe zimagwirira ntchito za mannose pochiza matenda okhudzana ndi matenda ndi chinsinsi chokulitsa ntchito yake yachipatala.
      M'zaka zaposachedwapa, pakhala maphunziro ambiri pa mannose. Lero, tikambirana ngati mannose angakhudze chithandizo cha matenda a mkodzo. Matenda a mkodzo ndi matenda omwe amayamba chifukwa cha tizilombo toyambitsa matenda pamtundu uliwonse wa mkodzo, kuphatikizapo impso, ureter, chikhodzodzo, urethra, ndi zina zotero, koma matenda a mkodzo nthawi zambiri amakhala ndi chikhodzodzo ndi urethra. Chifukwa cha kusiyana kwa thupi pakati pa abambo ndi amai, amayi ali ndi mwayi waukulu wotenga matenda a mkodzo kusiyana ndi amuna. Kafukufuku amasonyeza kuti amayi ali ndi mwayi wokwana 50 peresenti wokhala ndi matenda a mkodzo pa moyo wawo wonse, ndipo pakati pa gawo limodzi mwa magawo atatu ndi theka la omwe ali ndi kachilomboka amatha kutenga kachilomboka pakatha chaka chimodzi.
      Kuyambira m'ma 1980, mannose akhala akugwiritsidwa ntchito ndi madokotala ogwira ntchito pochiza matenda a mkodzo. M'zaka zaposachedwapa, ndi umboni wochuluka wa kafukufuku wotsimikizira kuti mannose amachiritsira komanso amateteza, ntchito ya mannose pochiza matenda a mkodzo yakhala ikukopa chidwi cha mankhwala ambiri.
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      Kodi mannose amagwira ntchito bwanji?
      Ikatulutsidwa kudzera mu impso, chikhodzodzo, ndi mkodzo, mannose imatsekereza maselo odutsa ndi mabakiteriya omwe amayesa kumamatira ku maselo, zomwe zimapangitsa kuti mabakiteriya asathe kumamatira ku chikhodzodzo ndi ma cell a mkodzo, kutsekereza njira ya matenda a bakiteriya, ndipo mabakiteriya omwe sangathe kumamatira ku minofu ya mkodzo amatsatira mkodzo kuchokera mkodzo. Matenda ambiri a mkodzo amayamba ndi uropathogenic Escherichia coli (UPEC). UPEC imamangiriza ku mannose pamwamba pa ma cell a epithelial a chikhodzodzo kudzera mu mapuloteni a FimH ndipo samatsukidwa mosavuta ndi mkodzo. Anasintha mannose kuti apeze mannoside (M4284). Kugwirizana kwake ndi puloteni ya FimH ndi yoposa 100,000 kuposa ya mannose, koma sichimamatira pamwamba pa chikhodzodzo ndipo imatha kutulutsidwa ndi E. coli mu mkodzo.
      Mu kafukufuku wapadziko lonse wa 2016, odwala omwe adatenga mannose kwa masiku 13 adachepetsa kwambiri zizindikiro komanso kusintha kwakukulu kwa moyo wawo monga momwe amawunikidwa ndi mafunso. Pofuna kupewa matenda obwera chifukwa cha mkodzo, ochita kafukufukuwo adagawa odwalawo m'magulu awiri, gulu lothandizira linapitirizabe kutenga mannose, gulu lolamulira linalibe kalikonse. Chotsatira cha gulu la mannose, 4.5 peresenti yokha ya kubwereza mkati mwa miyezi isanu ndi umodzi, poyerekeza ndi 33,3 peresenti ya gulu lolamulira. Ofufuzawo anapeza kuti mannose amatha kuthandiza kuchiza matenda oopsa a mkodzo ndipo amatha kuteteza kuti matenda a mkodzo asayambikenso.