Yisiti beta-glucan ndi polysaccharide yogwira ntchito yochokera ku khoma la cell ya yisiti. Mu 1941, Dr. Pillemer anapeza chinthu chomwe chimapangitsa kuti chitetezo cha mthupi chitetezeke. Mu 1961 Riggi adazindikira kuti chinthu chomwe chimagwira mu yisiti glycan ndi beta-glucan [1]. Magwero wamba a beta-glucan amaphatikizanso oats, bowa, nyanja zam'madzi, ndi zina zambiri, chifukwa thupi silingathe kupanga kapena kubisa beta-glucan palokha, liyenera kuwonjezeredwa ndi dziko lakunja.

Kuphatikiza pa β-glucan ndi khoma la cell ya yisiti palinso mannose osungunuka m'madzi ndi chitin pang'ono, β-glucan amawerengera 30% mpaka 60% ya kulemera kowuma kwa khoma la cell, mkati mwa khoma la cell, ndi la polysaccharide yokhazikika, ntchito yayikulu yokhudzana ndi thupi ndikusunga mphamvu zama cell, kusunga cell cell. Misaki et al. anapeza kuti mapangidwe a yisiti β-glucan amapangidwa makamaka ndi β-1, 3-bond, ndipo ali ndi gawo lina la β-1, 6-bond residues.

Mphamvu ya immunomodulatory ya yisiti beta-glucan imatengera kulunjika kwake, kuthekera kwake kumangiriza ma receptor enieni pamwamba pa maselo a chitetezo chamthupi, ndikukulitsa ntchito ya phagocytosis ya macrophages. Njirayi imathandizira kuti chitetezo cha mthupi chitetezeke mwachangu ndikusunga chitetezo chokwanira.

Beta-glucan imagwira ntchito makamaka pomanga mitundu itatu ya beta-glucan receptor [4]: ??(1) Dectin-1 receptor; (2) CR3; (3) Ma receptor ena, kuphatikiza cholandilira cholandirira ndi LacCer. Yisiti β-glucan ikalowa m'thupi la munthu ndikumangiriza ku cholandilira, imawonjezera phosphorylation ya intracellular immune receptor tyrosine motif (ITAM) ndi Syk, ndikuyambitsa njira ya PI3K/Akt, yomwe pamapeto pake imatsogolera ku phagocytosis, kufa kwa tizilombo tating'onoting'ono ndi kutulutsidwa kwa cytokine, kuti tipewe kutulutsa ma cell akunja. Ndiyeno inu kupeza zotsatira za chitetezo chokwanira.

Ubwino wa khungu la beta-glucan umawonekera makamaka m'mbali zotsatirazi [6]:

1) Mphamvu ya Antioxidant: β-glucan imakhala ndi antioxidant katundu, yomwe ingalepheretse kubadwa kwa superoxides ndi mitundu ina ya okosijeni (ROS) ndikuchepetsa kuwonongeka kwa kupsinjika kwa okosijeni pakhungu.

2) Mphamvu yonyowa: Ndi kulemera kwake kwa maselo, β-glucan imakhala ndi mphamvu yomanga madzi, yomwe imatha kumangirira mamolekyu amadzi pamwamba pa maselo a khungu, kuteteza madzi kutuluka, ndi kuchepetsa kutaya madzi kudzera mu epidermis (TEWL). Kuonjezera apo, imapanga filimu yotetezera pamwamba pa khungu, kuthandiza kusunga chinyezi ndi kufewa pakhungu.

3) Kukonza khungu ndi kuchiritsa mphamvu: Seo et al. adapeza kuti magwero osiyanasiyana a beta-glucan amatha kulimbikitsa kusamuka kwa ma keratinocyte a anthu (HaCaT) ndi ma fibroblasts akhungu (HDFa), ndikufulumizitsa kutseka kwa bala ndikuyambiranso epithelialization mumitundu ya mbewa [7]. Kuphatikiza apo, anti-inflammatory and anti-irritant properties a beta-glucan amathandiza kuthetsa kutupa ndi kufiira komanso kuchepetsa khungu lopweteka. Kafukufuku mu Journal of Therapeutic Dermatology adawonetsa kuti beta-glucan ndi njira yothandiza pochiza dermatitis yofatsa (eczema) [8].

4) Zotsutsana ndi ukalamba: Beta-glucan imathandizira kuchepetsa zizindikiro za ukalamba wa khungu, monga makwinya ndi kugwa. Imalimbikitsa kaphatikizidwe wa kolajeni ndi zigawo zina zapakhungu la extracellular matrix (ECM), ndikuwonjezera makulidwe ndi kukhazikika kwa khungu.

Kuphatikiza apo, beta-glucan imakhalanso ndi udindo wowongolera zomera zam'mimba, kuchepetsa cholesterol, anti-kutopa, thanzi la mafupa ndi zina zotero.

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