Pankhani ya kafukufuku wamankhwala am'mimba, Polydextrose yakhala ikudziwika kuti ndi chakudya cham'madzi chomwe chimasungunuka m'madzi. Komabe, kafukufuku wambiri m'zaka zaposachedwa wawonetsa kuti molekyulu yopangidwa mwachisawawa yopangidwa kuchokera ku shuga ndi "wosewera wosunthika" yemwe amasinthanso matumbo a microecology kudzera pamakina atatu a "dynamic viscosity regulation - kudyetsa bwino kwa microbiota - metabolite cascade reaction". Kafukufuku waposachedwa mu Nature Gastroenterology mu 2024 akuwonetsa kuti kudya tsiku lililonse kwa 10-15g ya polyglucose kumatha kukulitsa kukhulupirika kwa chotchinga chamatumbo ndi 37% ndikuchepetsa kuchuluka kwa chotupa cha IL-6 ndi 29%. Kupeza kumeneku sikungosokoneza kuzindikira kwachikhalidwe komanso kumapangitsa kuti pakhale njira zosiyanasiyana zogwirira ntchito kuyambira pamakampani azakudya mpaka zamankhwala azachipatala.

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Youdaoplaceholder0 Chapter 1 Decoding Science: "Whole digestive tract Intelligence" ya molekyulu

Youdaoplaceholder0 1.1 Viscosity deformation: "Kuyankha mwanzeru" kuchokera m'mimba kupita m'matumbo

Kusiyanitsa kwa polydextrose kuli mu kusintha kwake kwamphamvu kwa Ph-responsive viscosity:

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Youdaoplaceholder0 M'mimba (pH 1.5-3.0) : Unyolo wa mamolekyulu amalumikizidwa kudzera pa ma hydrogen bond kuti apange maukonde amitundu itatu, sopo wowoneka bwino mpaka 1500 mPa·s, amachepetsa kutulutsa kwam'mimba mpaka 45% (poyerekeza ndi 20% ya chakudya wamba;

Youdaoplaceholder0 Matumbo ang'onoang'ono (pH 6.0-7.4) : Zomangira za haidrojeni zimasweka pang'ono, kukhuthala kumachepetsedwa mpaka 400 mPa·s, ndipo kutsekemera kwa bile acid kumachepetsa kuyamwa kwa cholesterol ndi 18% popanda kukhudza kuyamwa kwa michere;

Youdaoplaceholder0 Colon ? (pH 7.0-7.5) : Kutentha kwa tizilombo kumayambika, kukhuthala kumasokonekera mpaka pansi pa 50 mPa·s, ma acid afupiafupi amafuta acids (SCFAs) amatulutsidwa, ndipo ndende ya butyric acid ikuwonjezeka ndi nthawi za 3.2, kuyambitsa mwachindunji epitheal cell (Figulial cell).

Youdaoplaceholder0 Technology Breakthrough : Ukadaulo wa SmartVisc? wa DSM utha kusintha ma curve a viscosity m'magawo osiyanasiyana powongolera kuchuluka kwa polymerization (DP value), monga fomula yamtundu wa G yomwe imapangidwira odwala omwe ali ndi gastroesophageal reflux, yomwe imapanga filimu yoteteza thupi yokhala ndi kukhuthala kofikira 2000 mPa·000 mmimba.

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Youdaoplaceholder0 1.2 Microbiota regulation: Kuchokera ku "kudyetsa kwamitundumitundu" kupita ku "kupindula komwe mukufuna"

Ma prebiotics achikhalidwe nthawi zambiri amalimbikitsa ma microbiota onse mosasankha, pomwe polydextrose imawonetsa kuthekera kowongolera bwino:

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Youdaoplaceholder0 Upstream inhibition : Kuwoneka kwamphamvu kwamphamvu kumapanga chotchinga chapakatikati, kuletsa kumamatira kwa mabakiteriya a pathogenic (monga Escherichia coli), kuchepetsa kuchuluka kwa tizilombo toyambitsa matenda ndi 52%;

Youdaoplaceholder0 Downstream proliferation ? : Zidutswa za oligosaccharide zinkagwiritsidwa ntchito makamaka ndi mabakiteriya opindulitsa monga Bifidobacterium ndi Roseella, ndipo kuchuluka kwawo kunawonjezeka ndi 68% pambuyo pa masabata a 8 (kutengera kutsata kwa metagenomic);

Youdaoplaceholder0 Metabolic synergy ? : Butyric acid yomwe imapangidwa imayambitsa cholandilira cha GPR109A, imathandizira kusiyanitsa kwa ma cell a T, ndikukulitsa index ya chitetezo cham'mimba kukhala 0.91 (pamalo azaumoyo> 0.85).

Youdaoplaceholder0 Mutu 2 Wogwiritsa Ntchito Mkuntho: Kuchita Zodutsa malire kuchokera patebulo kupita ku Bedi Lachipatala

Youdaoplaceholder0 2.1 Makampani Azakudya: "Injini yosaoneka" yokhala ndi ntchito zokwezedwa

Youdaoplaceholder0 Baking Revolution ? : Gulu la Meiji la ku Japan lapanga makeke a zero-sucrose pogwiritsa ntchito mwayi wosunga madzi (8.3g madzi / g) ndi kukhazikika kwamafuta (kulekerera mpaka 220 ° C) a polyglucose, kutsitsa kusinthasintha kwa shuga pambuyo pa chakudya ndi 41%.

Youdaoplaceholder0 Beverage Innovation : Nongfu Spring's Intestinal Sparkling Water, yomwe imagwiritsa ntchito mphamvu ya polyglucose yopangira mpweya wopangira mpweya kuti ithetse kudzimbidwa popanda kupsa mtima, idagulitsa mabotolo opitilira 8 miliyoni m'mwezi wake woyamba pamsika;

Kupambana kwa Youdaoplaceholder0 Meal Replacement : Soylent ku US imagwiritsa ntchito mawonekedwe a viscosity-gradient kukulitsa nthawi yotulutsa mphamvu pang'onopang'ono mpaka maola 6 ndikuwongolera kupirira kwa othamanga marathon ndi 23%.

Youdaoplaceholder0 2.2 Zakudya zachipatala: "chishango chotchinga m'matumbo" kwa odwala ICU

Kafukufuku wa RCT wa Sir Run Shaw Hospital, School of Medicine, Zhejiang University (n=204) akuwonetsa kuti:

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Youdaoplaceholder0 Kupewa matenda : Mu odwala a ICU omwe amawonjezeredwa ndi 15g ya polydextrose tsiku ndi tsiku, chiwerengero cha sepsis enterogenous chinatsika ndi 44%;

Youdaoplaceholder0 Kukonza kwa mucosal ? : Miyezo ya Plasma ligonin (chizindikiro cha kuthekera kwa matumbo) idatsika ndi 31% ndipo kuchuluka kwa ma cell a goblet kudakwera ndi 39%;

Youdaoplaceholder0 Immunomodulatory : Kuchuluka kwa Serum IgA kunakwera ndi 28%, ndipo chi?erengero cha CD4+/CD8+ T cell chinabwereranso pamalo abwino.

Youdaoplaceholder0 Mutu 3 Kusintha Kwaukadaulo: Kuchokera ku Mapangidwe a Molecular kupita ku AI-Enabled Precision Nutrition

Youdaoplaceholder0 3.1 Kusintha kwa Kapangidwe: Tsegulani Makonda pakufunika

Youdaoplaceholder0 Target viscosity : Poyambitsa unyolo wam'mbali wa sorbitol, polyglucose yamtundu wa C) idapangidwa, yomwe mawonekedwe ake amatsika kwambiri mpaka 10 mPa·s pa pH 7.0, makamaka kwa anthu omwe ali ndi vuto la kudzimbidwa;

Youdaoplaceholder0 Chikhalidwe Chowonjezera : Roguet, France, adapanga ukadaulo wa Probiocoat? microcapsule womwe umayika ma probiotics mu polyglucose matrix, ndikuwonjezera kuchuluka kwa asidi m'mimba kuchoka pa 15% mpaka 92%.

Youdaoplaceholder0 3.2 NZERU Zopanga: Kuphwanya Malamulo Okhudza Kulowerera Kwaumwini

Dongosolo la "Digital Twin of the Intestine" lopangidwa ndi NutriAI, kampani yaku Israeli, limaphatikiza milandu 200,000 ya data yamatumbo amunthu ndi mitundu yamadzimadzi, yomwe imatha kufotokozera momwe munthu angayankhire polydextrose:

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Youdaoplaceholder0 Kukhathamiritsa kwa Mlingo ? : The 8-12g/tsiku + fructooligosaccharide regimen yolangizidwa kwa odwala a IBS idachepetsa kuchuluka kwa matenda am'mimba ndi 67%;

Youdaoplaceholder0 Scene fit : Njira yolimbitsa thupi kwambiri yopangidwira othamanga, yomwe imakulitsa chiwopsezo cha matumbo ndi 40% ndikupewa kusapeza bwino kwa m'mimba panthawi yophunzitsidwa.

Youdaoplaceholder0 \ n \ nMutu Wachinayi: Chisokonezo Chamakampani: Nkhondo Yolimbana ndi Zaukadaulo M'misika ya madola matrilioni

Youdaoplaceholder0 4.1 Mpikisano Wamphamvu: Makampani aku China akudutsa pamapindikira

Youdaoplaceholder0 Baolingbao Bio : Ikani ndalama zokwana yuan 800 miliyoni kuti mumange ukadaulo waukulu kwambiri padziko lonse lapansi wopangira polyglucose, ukadaulo wa enzymatic synthesis kuti mukwaniritse chiyero cha 99.9%;

Youdaoplaceholder0 Hualixi Biotech : Kupangidwa kwa nano-fibrotic polyglucose, kukhudzika kwa mamasulidwe a viscosity kuchulukitsidwa ndi nthawi za 4, kuvomerezedwa ndi NMPA Special Medical Food;

Youdaoplaceholder0 Transnational layout ? : DuPont ikugwirizana ndi Mayo Clinic kuti apititse patsogolo mayeso achipatala a Phase III a polydextrose popewa khansa yapakhungu.

Youdaoplaceholder0 4.2 Zovuta Zachidziwitso: Kusiyana kuchokera ku Labu kupita ku Mass Market

Ngakhale pali umboni wokwanira wa sayansi, kafukufuku wa ogula akuwonetsa kuti:

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Youdaoplaceholder0 Knowledge Blind spot : Ndi 31% yokha ya anthu omwe amamvetsetsa kusiyana kwa ntchito pakati pa polydextrose ndi ulusi wamba;

Youdaoplaceholder0 Malingaliro olakwika a Mlingo : 45% ya ogula molakwika amakhulupirira kuti "zambiri ndizabwino", zomwe zingayambitse kusapeza bwino monga kutupa;

Youdaoplaceholder0 Industry Response : Chinese Nutrition Society inatulutsa White Paper pa Kugwiritsa Ntchito Polydextrose, ndikuyika malire otetezeka a 15g patsiku.

Youdaoplaceholder0 Chapter 5 Future Vision: Redefining Fibre's 'Smart Boundary'

Youdaoplaceholder0 5.1 Kupambana kwa Brain-Gut Axis: Mlatho wa Molecular kuchokera kumatumbo kupita ku Emotion

Zoyeserera zaposachedwa za nyama ku California Institute of Technology zapeza:

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Youdaoplaceholder0 Thandizo pa Nkhawa : Mbewa za gulu la polyglucose intervention zinawonjezera nthawi yawo yofufuza mu mayeso a maze ndi 53%;

Youdaoplaceholder0 Mechanism tracing ?: Butyric acid imayendetsa BDNF kufotokoza mu hippocampus kudzera pa chotchinga chamagazi-muubongo, ndikuwonjezera kuchuluka kwa ma synaptic ndi 29%.

Youdaoplaceholder0 5.2 Synthetic Biology: The 'Ultimate Form' ya ulusi wopangidwa

Kampani ya Ginkgo Bioworks ku United States yasintha mitundu ya yisiti pogwiritsa ntchito ukadaulo wa CRISPR-Cas9 kuti ibise mwachindunji "gene-encoded polydextrose" yokhala ndi magwiridwe antchito:

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Youdaoplaceholder0 Precise targeting ? : Ikhoza kulimbikitsa makamaka kukula kwa Achaemenia, ndipo kuchuluka kwake kumawonjezeka ndi 80% mu zitsanzo za kunenepa kwambiri;

Youdaoplaceholder0 Smart response ? : Sensa ya pH yomangidwira, kusintha kwa viscosity kusintha kwasintha kukhala ± 5 mPa·s, akuyembekezeka kulowa m'mayesero azachipatala mu 2026.

Youdaoplaceholder0 Mapeto: Pamene Molecular Intelligence ikumana ndi Gut Ecology

Ulendo wa sayansi wa polydextrose ndi mbiri yobwerera kuchokera ku "zopangidwa ndi mafakitale" kupita ku "intestinal ecological engineer". Imatiuza kuti zotsogola zenizeni za thanzi nthawi zambiri zimachokera pakuwonongeka kozama ndi kulinganizanso m'malire chenicheni cha chinthu. Monga momwe Jennifer Doudna yemwe adalandira mphotho ya Nobel anati, "Synthetic biology imatiphunzitsa kuti mamolekyu amatha kupatsidwa 'kutha kuganiza'." Pakusintha kwaukadaulo kwa thanzi lamatumbo, polydextrose ikhoza kukhala poyambira - "mamolekyu anzeru" ambiri akalowa nawo pankhondoyi, anthu pamapeto pake adzakwaniritsa njira zothana ndi matenda osatha.