Youdaoplaceholder0 1.1 ???? ??????? ????????? ??????

?????? ?????????? ????? ????? ?????? ?????, ??????????????? ???????? ????????? ??? ??????? ????????????? ???? ????????: ????????????? (??????? ???????? ??? ?????????), ?????????????? (??????? ????????), ??? ???????????? (??????? ???????)? ?????, ?????? ???????? ?????? "????? ?????" ?? ????? - ??? ???? ????? ??????? ???????????? ????? ??? ??? ??????? ???? ?? "???????? ??????" ????? ???????? ??? ??????? ???? ??? ???? ?????? ?????? ??? ??????? ?????? ?? ????? ???????? ?????? ????? ???????? ???? ??????, ??? ??????????????? N-?????? ?????????????? ?????????? ???????? ?????????? ?????? ??? ??? ????? ??? ?????? ??????? ?????????? ????? ???? ???????

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Youdaoplaceholder0 1.2 ????? ??????????? ????? ???? ?????? ????????? ?????????? ??????????? ?

???? ???? ??????????, ???????? ????????? ???????? ??????? ?? ?????? ??????? ??????? ?????????? ??????????????? ????? ????? ??? ???????? ????????? ????????? ??? ????????? ????????? ?????? ????????? ????????????? ????? ???????? ?????? ?????? ?????? ???? ????????? ???? ?????????? ??????? ???????? ???? (CRUK) ?????? ?? ???????? ?????? ???????? ???? ????? ?????? ?????? ???? ???? ???? ???????: ???????????? ????? ???? ?? ???? ??????, ????? ?????? ??% ?????? ????? ?????? ?????? ??? ??% ????? ???????, ??? ?????????? ??? ???????????? ???? ??????? ????, ??????? ??????? ???? ?.? ??? ?????? ???????? ??? ???????? "????? ???? ????? ????? ??????????? ???" ???? ????????? ??????? ????? ??????

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Youdaoplaceholder0 ?????? 2 ?????-????? ???????? ?????? ?????: ?????? "????? ???" ??????? ?????????? ??????? ?

Youdaoplaceholder0 2.1 ?????????? ??????????: ????????? ????? ???????? "???????? ????" ?

?????? ?????????? "??????? ??????" ????????? ???????? ??????? ?????? ????????? ??????? ?? ??? ???? ??????? ????? ??????? CRUK ?? ??????-13 ???????? ??????? ??????????????? ???????? ???????? ??????? ?? ???????? ??? ??? ???? ???? ??????? ???????? ????????????? (GLUT1/3) ???????? ?????? ????? ?????????? ????????? ????????? ?????, ?????? ????? ???, ??? ???????????? ?????? ??????-6-?????? (M6P) ?? ????? ????? ???????????? ??????? ??? ?????????? ??????????? ?????????????? ???? ?????? ???????? ????? ??? ?? "?????????? ????" ??? ??????? ??? ?????? ??? ???, ???? ATP ????????? ???? ??? ?????????????? ??????? ??????? (ROS) ????????? ???? ???, ????? ????? ?????????? ??????????? ?????? ??? (????? 1)?

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Youdaoplaceholder0 2.2 ??????????? ?????????: ????? ?????????? "?????? ????" ???????? ?

2023 ???????, ??? ??????????????? ?????? ?????????????? ?? ?????? ?? ????? ?????? ??????? ?? ?????? ?? "????????? ???????" ????? ??????? ????????? ???????????? ?????? ??????????????? (PDAC) ??????, ?????? ???????? ???????? H3K27 ????? ?????????? ?????? ????????? ????? ????? ???????, ???? ???? ????????? MYC ??? KRAS ? ????????????????? ????????????? ???? ???????? ????? ???????????? ?????, ??? ?????? ??????????????? ?????? ?????? - ??? ??????? ???? ?????? ????, ????? ????????? ?????????? ??? ??????????? ???? ???, ???? ????? ???????? ???? ???? ????? ?????? ????

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Youdaoplaceholder0 2.3 ??????? ??????? ?????? ???????????: PD-L1 ? ? "????-???? ???"?? ???? ????

????????? ???????? ???? ?? ?????????? ?? ??????????? ???? ??????? 1 (PD-L1) ? ?????????????? ???????????? ????????? ??? ?????? ??????? ?????????? ????? ???????? ??????????? ???? ???????????????? ?????????? ???????? ?? ?????? PD-L1 ???????? 192 ?? ??????? ??????????? N-???????????????? ???? ???????, ???? ???? ??? ????? ????? ?????? ??? ??? ???????? ????? ??????? ? ????? PD-L1, ???? "???? ???" ? ??????? ???????, ????? E3 ubiquitin ligase FBXW41 ?????? ????? ?????? ??? ?????????? ?????? ???? ??????? ???????? ??????, ?????? ??? ?????-PD-1 ????????? ?????? ?????????? ?????? ???????? ????? 28% ?? 79% ?? ?????? ??????? ??(????? 2)?

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Youdaoplaceholder0 ?????? ?????? ???? ?????????? ??????? ????????? ?????? 3: ?????????? ???? ????? ?????? ?

Youdaoplaceholder0 3.1 ??????-?????????? ??????? ????? ??? ???? ?

CRUK ? ???????????? ????? ??????, ???? ?????? ???? ?????????? ?????? ????????? ?????? ???????, ??? ?????????? ????? ???? ??????? ???? ???????? ?????, FOLFIRINOX ?????????? ?????? ???? ??????? ???? ???, ????? ?????? ??????? ??? 42 ????? 98 ??? ????????? ?????? ???????, ??? ??????????? ????? ?????? ????????? MD ???????? ????? ???????? ???????-???????? ???? ????? ?????? ??? ????? ???????????? ???????: ?????? ?????????????? ?????? ??? ????? 45% ?? 72% ?????? ???????? ?????, ????????? ??? ???? ????? ?? ????? 15% ?????? ?????? ????? ??????????? ??? ?????? ???? ?????????? ???????? ?? ??? ???-????????? ????????? ???? ???????? ??????-?????? ?????????? (PMI), ???? M6P ?? ??????????-6-?????? ?? ?????????? ??? ?????????????? ?? ???? ???? ????? ?????????

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Youdaoplaceholder0 3.2 ???? ???????? ?? ????? ?????? ?

2022 ?? ????? ??????? ?????? ????? ???????? I ?????????? ??????? (NCT05220739) ?? 32 ?? ???????? ????? ???? ?????? ???? ????? ??????????? 5g ?????? ????? ????? ??????? ???? ???????, 8 ?? ??????? ?????????? ?????? DNA (ctDNA) ???? 50% ?? ???? ????? ???????, ???????? ??? ??????? ????? ??????? ???? ?????????? ?????? 31% ????? ???????? ?????, ???????? ???? 10g ?? ?????? ?????, 3 ?? ??????????? ?????? III ?????? ???????, ???? ????? ????? ?? ??????? ???????? ?????????? ????? ??????? ?????????, ????-????????? ?????????????? ??????????????? ??????? ??? ??????????? ?????? ????????? ????????? ???? ?????????????? ???? ???????? ?? ????????? ??????-??????????? ????? ?????? 78% ?? ????????, ??? ????????? ????????? ?????? ????? ??????

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Youdaoplaceholder0 ?????? 4 ????? ?????????? ??? ?????: ???? ??????? ?????? ????????? ?

Youdaoplaceholder0 4.1 ?????????? ?????????? ???? ??????? ????????? ?????? ??? ?

????????? ????? ??????????? ?????? ?????? (????? ????? ?????????)

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????? ??? ????????? ???? ???????? (?????) ???? ????? ???????

???? ????? ??????? ?????? ?????

????? ???? ?? ????? ?????, ???? ?????-?????? ???? ???????? (???????? ??-?? ?????) ???? ????? ??????? ?????????? ???????? ?????? ?????????????????? ????????? ?????? ??????-? - ?????????? ?????? ???????????? (MPG) ???? ?????????? ??? ????????? ?? ?????/?????? ?????? ????? ??? ???????? ??/??????????? ????? ?????? CRISPR-Cas9-???????? Saccharomyces cerevisiae ??????????? ?????? ??? ???? ????? ??????????????? ??????? ?????? ????? ????? ????? ????-??????? ?????? ??????? ??????? ????? ??????

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Youdaoplaceholder0 4.2 ??????? ?????? ??? ????????? ??????????? ?????? ??? ?

"???????-????????? ????" ????? ???????? ???? ????, "?????? ???? ????? ????????" ???? ???? ??????? ?? ?? ?????? ????????? ?????? ????? ??????????? ??? ?????, ????? ????? ????????? ?? ??? ????????? ????? 2023 ???????, US FDA 23 ?? ???????? ??????? ???? ???? ???????, ???????? "???? ??????? ??? ???? ???????? ?????? ??????? ???? ????? ????? ?????" ???? ??????? ??????????? ????????????? ??????? ?? ???? ????? ?????? ? ???? ?????? ????? ????? ???????? ???????? ???? ??????? - ?????? ????????? ???????? ?? ?????????? ???? Faecalibacterium prausnitzii ? ?????????? 80% ????? ??? Fusobacterium nucleatum ?? ????? ??? ?????? ???? ????????? ??????????? ????? ???? ??????? ???? ?????? ????? ?????

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Youdaoplaceholder0 ????? ?????? ??????? ????????: ???????-?????? ???? ????? ?????? ?

Youdaoplaceholder0 5.1 ????????? ????????? ??????????? ?????? ?

?????? ?????????? ?????? ???? ?????? ????????? ???????? ?????? ??? ?????? ????????????? ???? ???????????? ?????? ?????? "?????? ???????????? ?????" (MSS) ????? ?????? ?????? GLUT1 ? ??????? ????, ???????????? ??????????? ??? PMI ?????????? ?????? ?????? ??? ??????? ?????? ????? ??????????? ????????? ??????????? ????????? ???????? II ?????????? ???????? ????????, ???????? ??????????? ????? ????? ????? ???? ≥75% MSS ????? ???? ???????????? ????? ??????????? ??????????? ????? ???? ?????????? ???????

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Youdaoplaceholder0 5.2 ????? ??????? ?????? ??????????? ??? ?

????????? ?????? ??? ???????? ????????? ?????? ?? ???????? ?????? MIT ?? ?? "?????-?????????????" ???????? ??????? ?????, ???? ?????????? ???? ????????? ????? ???? ????? ???? ?????? ????????? ?????? ?????? ???? ?????? ????? ??????? ???? ????? ??????, ??? ????????? ??????-???? ?????? ????????? ????????????? ??????? ???? ??? ????, ??? ???? ???????????????? 60% ????? ???????? ?????? ???? ???? ??????????????? ?? ?? ????? ?????: ?????????????? Ce6 ???? ??????? ?????? ???, ?? "????-?????? ???????????? ??????" ?????? ????? ?????? ????-?????????? ???? ?????? ?????? ???????????, ???? ???? ?????? ???????? ???????? ???????? ??????

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Youdaoplaceholder0 ????????: "???? ???" ?????-?????? ??????????? ???????? ????? ?

????? ??????? ??? ?????????? ????????? ?????? ?????? ?????? ?????-?????? ?????? ?? ??????? ?????????? ?????????? ??????????? ???????? ????????? ?????????, ???????????? ?????? ???????? ?????????, ??? ???? ??? ???-???????? ?????? ?????? ???? ?????? ?????????? ?????? ?????? ?????? ???? ?????????? ?? ?????????? ???? ?????????????, ??? ???????? ?????? ??? ?????? ??????? ??? ?????????? ???????? ?????, ????????? ????????? ??? ???? ???? ??? ????? - ????? ?????? ???????? ?????? ????? ????? ????????, "????? ???? ??? ????? ???????? ??????, ??? ???????????? ???? ????? ?? ?????????? ????????? ???? ??????????? ????????" ????? ??? ??? ?????????? ??????????? ????? ?? ?????? ?????, ??? "???? ??????" ????? ????????? ?? ???? ???? ????? ????????