??? ?????? ???????? ?????? ???? ??? ??? ??????? ?????? ????? ????????
???????? ???, ?????? ??????? ???? ???????, ?? ???? ??????? ???????? ???? ?????? ??????? ?????????????? ??????? ??????? ???? ?????????? ???????? ???????? ?? ???????? ??? ????? ????? ????? ??????????? ???????? ???, ???? ?????????? ??????? ??????????? ??? ??? ???? ?? ??????????? ??????????????? ?????? ???? ????
???-????????? ?????? ???? ?????? (NAFLD), ??????? ??????? ???? ??? ??????? ???????? ????, ??????? 150 ??????? ???? ???? ??????, ???? ?????? 10-20% ???? ???-????????? ????????????????? (NASH) ?? ?????? ????, ??????? ?????? ??? ???? ??? ????? ?????? ???????? ???, ??????? ??????????? ????? NASH ????? ????? ??????? ??? ??? ???????? ??? ???? ????? ??? ?????? ???? ??? ????? ?????? ???? ????
????????, ??? ????-???? ?????????????? ?????? ??? ??????? ?????? ????????? "????????????? ?????????? ?????? ????? ??????? ????? ??? ?????????" ?????? ?? ?????? ???? JAMA ???????? ???? ?? ?????? ????????? ?????? ???? ????
???????? ???????? ?? ???????? B3 ???? ???????, ?????? ??-????????? ?????? ???? ??? ???? ??????? ????????? ???????? ??????? ?????? ?????, ????????? ????? (≤18.4mg/???) ??????? ??????????????? ??????? ???????? ????? (≥26.7mg/???) ???? ??????????????? ????????? ???????? ??????? ?????? 30% ????? ???? ???? ?????
??? ????????, ????????? ???????? 53 ???? ???? 4,315 ?? NAFLD ??????? ????? ????????? ??? ????????? ??????? ????? (NHANES) ???????? ?? ????? ???????? B3 ????? ?????? ??? ???-????????? ?????? ???? ????? ????? ??????? ?????? ????? ???????? B3 ????? ??? ???????? ??????? ???? ?????? ??????? ???????? ????????
??????????????????? ???????? B3 ????? ???? ???? ??? ?????? ???????? ?????? ??????????: ?? ????? ?????? (≤18.4mg/???), ????? ????? ?????? (18.5-26.6mg/???) ??? ???? ????? ?????? (≥26.7mg/???)?
???????? 8.8 ????? ?????? ???? ??????, ??? 566 ????? ?????? ?????? ??????????, ???? ?????? 197 ?????? ?????? ???????? ????? ????????
?????????? ???????? ?? ???????? ???? ??????? ??????????????? ?????? ????????? ???? ??????? ??????????????? ??????? ???????? ??????? ?????? 30 ??????? ??? ?????
??? ????, ???????? ???? ??????? ??????????????? ???????? ?????? ?????? 35 ??????? ????? ???????, ?????? ??? ???????????? ????? ?????????????? ??????
???? ?????????? ???????? B3 ????? ??? ?????? ??? ????? ???? ??????? ???? ?????? ?? ?????????????? ????????? ?????? ??????, ???? ?????? ??????? ??????? ??-?????? ??????? ??????????? ???? ????? ??????
???????? ???????, ??????? ????? NAD ????????? ?? ???????????? ??? ???? ???? ???????? ??? ???????? ???? ?? ?????????????? ?????? ???????? ???????? ????????? ???????? ??? ???? ???????? ?? ??????? ?????? ?????? ????? ???????? ??? ???? ????? ???????? ????? ????????? ?????????????? ????????, ??????? ???? ?????????? ??? ???????? ??????? ??? ?????? ??????? ??? ????????????? ???????? ??? ???????????? ??????????? ??? ????? ???, ????????????????? ????????????????? 2 ??? NADPH ????????? ????????????? ????? ??? ??? ???????? ???????? ?????????? ?????? ???? ???????
??? ??????????? ?? ?????????? 2023 ??, ??? ????-???? ?????????????? ?????? ??? ??????? ?????? ????????? ?????????????? ?????????? "???????? ??????? ??????? ??????? ?????? ??? ??? ?????????? ?????? ???? ??????: NHANES 2003-2018" ?????? ?? ?????? ???? ?????? ????????
???????? ???????? ?? ???????? B3 ?????????????? ??-????????? ?????? ???? ???? ??? ???? ???? ???? ????, ??????????? ???????? ??????? ????? (≥29.2mg/???) ???? ????????? ????????? ??????? ????? (≤16.3mg/???) ??????? ??-????????? ?????? ???? ???? 31% ??? ???? ?????
??????? ????? ??????, ??????????? ????? ??? ?? ???????? B3 ?????????????? ??-????????? ?????? ???? ???? ??? ???? ??? ??-????????? ?????? ???? ???? ??????? ????????? ????? ???? ??????? ????? ?????? ???? ????? NAFLD ??????? ????????? ????? ???? ??????? ?????? ????? ????? ???? ???????? B3 ? ????????? ?????? ??????? ????? ???? ???? ?????? ???????