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???????? (MM) ?? ??????????? ?????? ???? ????? ???????????? ????? ??????? ??? ??? ??? ???? ????? ???? ??????? ??????????? ??????, ???? ???? ???? ??? ??? ??? ???? ??????????? ??? ????????????? ?? ???? ?????? ??? ????????? ???? ?????? ??????
????????, ????????????? ?????? ???????? ????????????? ??? ??????????? ???????? ?????????????? ????????? "????????? ?????? ?????? ????????????-?????????? ????? ?????? ?????? ??????????" ?????????? ???? ???????? ???????? ???? ???????? ??? ?? ?????? ??? ????-???? ????? ????? ??? ??? ???????? ????? ??? ?????? "?????? ?? ??? ?????? ?????????
???????? ???????? ?? ???????? ?? ???? ???????? ????? ?????????? ???????? ????? ?????? ????? ?????????? ??????????-??????? ????? ????? ?????? ??????? ??? ????? ??? ???????? ??????????? ???????, ??? ??? ????? ??????????? ???????? ?????? ???? ??????????? ??? ?????? ???? ??? ????, ??? ?? ??????? ?????? ????? ????
??? ????????, ????????? ????? ????? ????????????? ???? MM ??? ??????????? ?? ?????? ?????? ???????, ??????????? ????????????? ?? ????? ?????????? ????? ??????? ??????? ??? ??????????-??????? DNA ??????? ?????? ??? ???????? ??? ?????? ???????? ?????? ????? ???? ???????? C ???????? ????????
????????? ??????? ??? ?????? ???????? C-??????? DNA ?????? ???? ??????? ??? ?????????? ?? ?????? ???? ???, ?????????????? (HaCaT) ???????, ?????? ??????? ?????? ????? MM ????? ????????? DNA ?????? ???? ???????? ???? ????: ???? ????????????? ???? SK23 ???, ????? ????????????? ???? SK28 ???, ????????????? ???? A375P ??? A375M ???, ???????? HaCaT ????? DNA ?????? ????????? ?????? ?????
??? ????, ????????? ?? ?????????? (?????????? ??????????) ?????? ??????? ????? ????? ??????? ??? ????? ???????????? ???????? ??????? ??? ?????????? ?? ?????????? ?????????? ????? ????? ???????????? ??????? ???? ??????? ?????
??? ??? ?????? ?????????? ??????????? ?????????????? ???? ?????????? ???????? ?? MM ????????? HaCaT ??? ??????? ?????????? ??????????? ?????????????? ???? ???? ???????? ???????, ??? ??????? ??? ????? ???? DNA ?????, ????? ???????????? ??? ????????????????? ???? ??????? ?????
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??????????? ?????????? ?? ????? MM ??? ????, ???????? C ???????? ?????? ??????? ????????? DNA ?????? ???? ?????? ?????? ???????, ???????? HaCaT ?????????? ????? ?????????????? ?????, ??? ??????? ????????? DNA ????? ??????? ???? ??????? ?????
??? ????, ???????? C-??????? ????????????? ?????? ???? ??????? ???????????? SK23 ??????????? ???????? (18.5%) ??? ??-???????????? A375P ??????????? ????????? (14.2%) ?????
???????? ?? MM ??????????? ??????????? ??????? ??????????? DNA ????? ??? ????????????? ??????? ?????? ??????? ??? ???? ???? ???? ???, ????????? DNA ???? ?????????? ?????? ???? ???????? C? ???????? ???? ???????? ???????? ??? ????????? ?? ????? MM ??? ????, ???????? C ???????? ?????? ??????? DNA ???? ?????????? ?????? ???? ?????? ?????? ?????, ?????? HaCaT ??? ???? ?????? ??????? ??? ????? ???? ??? ?? ??????? ???? ??????? ????
?????????????? ??? ?????, ????????? ???????? ??????? ?? ???????? ?? ???????????-??????? MM ??? ???????? ?????? ????? ?? ?????, ??? ?????????? ?? ???????? ?? HaCaT ????? ?? ??????? ?????? ????? ????? ???? ????? MM ???? ???????????-??????? ??????? ?????? ?????, ??? ????? ???? ??????? ???? ??????? ?????
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????????? ???????? ?? ???????? ?? ??????? ?????, ???? ????? ????? ????? ????? ?????? ??????? ??? ????? ??? ??????? ???? ???????, ????????? ???????? ???? ?? ???? ?????????? ???? ???????, ?????? ????? ????? ???? ????? ?????????? ?????? ??? ??????? ???????
???????? ?? ?? ????? ?????? ???????? ??? ??? ?? ????? ???? ?????? ???? ??????? ?????????, ????????? ??????? ?????? ?? ?????????? ???????? ?????????? ?????? ????? ???? ???????? ???? ?? ??????? ????? ??????? ??????????
??????? ?????, ??? ?? ?????? ?????? ?????? ?????????? ????? ?????? ???? ????? ??????????? ?????? ????? ????? ???? ?????????-??????? ?????????? ????? ??????? ?????? ???????, ????? ??? ???????? ??????????? ???????, ??? ???????? ???????? ???? ???????? ?????? ???????, ???? ???? ?????? ????? ?????