??????????? ?????? ??????????? ??????? ?????? ????? ?????? ?????, ?????????? ????? (PC), ?? ???? ???? ???, ??????? ???? ??? ???? ???? ???? ?????? ??????? ????? ????? ?????? ???? ????? ?? ???????? ????? ????? ????? ???????? ???? ?????, ?????????? ????? ??? ?????? ??????? ?? ????? ?????? ???????? ?????? ???? ????? ??????????? ?????? ?????????

????? ???, ???????? "?????? ???, ????? ????????????" ???? ?????? ???, ??? "????????????" ??????? ??? ????? ????? ?? ?????? ?????????? ????? ?? ?????????? ????????? ???? ??? ???? ?????????? ?????????? ??????????? ???????? ??? ????? ??? ??????? ????????? ?????? ????? ???????????, ???? ??? ?????????? ????? ???? ????????? ?????????? ????? ?????? ???????? ??? ??????? ????????????? ????? ?????????

?? ???????, ??????, ????? ????????? ?????? ??????????? ??????? ???? ????????????? ?? ????? ??????????? ????????? ????????? ???????? ???????? ??????? ???? ?????? ????: ????????? ????-?????????? ?????? ??? ? ???????? K ????????? ????????? PI ?-?????? VPS?? ??????? ???????? ?????

???????? ???????? ?? ?? ????-?????????? ??????????, ????????? (???????? K3), ?????????? ????? ???? ????????? ??? ???????? ????????? ????? ???????? K? ?? ??-??????? ?????????, ???? ???????? ???? ????????? ?????????? ???????, ??? ???? ??????? ??????? ??????? ???? ???? ???????? ??? ???? ??????? ???????? ??????

?????? ???????? ???????? ?? VPS34 ????? ????????????????? 3-?????? (PI3K)? ?? ?????? ??????, ????????? VPS34 ? ????????????? ???? ???????, PI3P ? ??????? ????? ??????? ??? ?????????? ????? ?????????? ?????? ???? ??????????? ??? ?????? ???????? ????????, ?????? ????????? ???? ???? ??????? ??? ???? ??? ??????? ???? ????? ???? ?????????? ????? ??????? ???? ??? ????, ?????? ?? ??????????? ?? X-???????? ???????????? ???????? (XLMTM) ???? ?? ???? ???????? ???????? ????????? ? ?? ???????? ?????? ???? ????

??? ??????????? ????? ????? ????????? ?????? ?? ??? ?????? ?????????? ???? ?????? ??? ??? ??????? ???????????? ????????? ????? ??????? ???? ???????? ???? ???????? ???? ???? ?????? ????????

???? RapidCaP ????? ??????????? ?? ????-?????????? ??????????, ????????? ??????? ??????? (MSB) ???? ???????? ???????, ??? ?? ????? ???? ???????? K ? ?? ????????????? ?????? ?????????? ?? ????? ???? MSB ? ???????? ?????????? ?????????? ????? ???? ????????? ???????? ??? ?? ?????? ?????? ?????? ?????? ????????

???????? ?????, ???????? ???????? ??? ???????? ???????? ?? MSB ?? ???? ????? ???? ??????? ????-?????????? ?????????? ??? ????? ?????? ?????????? ????? ???? ??????? ?????????? ????? ?????? ???????? ???? MSB PI3K ??????? VPS34 ? ????????????? ???? ???????, PI3P ? ????????? ????? ??????? ??? ??????????? ????? ?????? ???????, ???? ?????????? ????? ?????????? ??????? ???? ??????? ??? ????, X-???????? ????????????? ???????? (XLMTM) ??, MSB VPS34 ? ??????? ????????????? ???? ???????, PI3P ?? ???????? ??????? ????? ??????????? ?????? ??????????? ????????