??????????? (????????? 5-????????? ???????, CDP-???????) ????????????????? ??? ?????????? ??????? ???? ??????????? ??? ????????? ?????? ??? ?????? ??? ???????????? ?????? ???? ??????? ?????? [1]? ??????????? ?????? ??????? ?????? ????-GPC ??????? ???? ???? ???, ?????? ??? ???? ?????? ???? ?????????? ????????? ????? ???????? ???? ?????????? ?????? ????, ????????????? ????? ???????? ????? ??????? ????? ????? "????????????" ??? ?????? ???????? ???? ????? "CDP-???????" ???? ??????? ????????? ??????? [2]? ??? ????? ????? ???, ??? ????? ????? ????? ???: ????????? ??? ???????? ?????? ????-???????? ???? ??????? ????? ???, ?????????? ???? ??????? ???????????? ??? ???????? ?????????? [3] ????? ????? ???? ????????? ??????? ??????? ?????? ????????? ???? ????? ?????? ???? ??????? ????????????? ??? ???????? ??????????????????? ?????? ???? ???? ??????????? ?? ???? ???????? ??????? ??????? ????? ???? ????, ?????? ??????? ??????? ??????????? ? ???? ??? ??? ??? ??????? ??????????? ??????? [4,5,3]?

??? ????? ??? ???

??????????? ????????????????? ??? ??? ??????? ??????????? ??????? ?????? ???? ????????????? ??????, ??? ?????????? ???????????? ??? ???????? ?????? ??? [4,6]? ??? ???????? ???? ???????? ?????? ??????? ??? ???? ????? ??????? ??????? ??????????????? ???????? ??????? [4,5,2]? CDP ??????? ? ?????????? ???? ???????????????? ??? ??????????????? ?? ??????? ???, ???? ??????? ???? ?? ???????????? ?????? ?????? ??????? ???? ??????????? ????????? ??????? ?????????? A2 ?? ???? ???? ??? ??? ????? ??????????????? ??????????? ?? ?????? ??? [7,8]? ?????????, ??????????? ???????????????????????? ???????? ??? ??? ?????? ????????? ????????? ??? ???-????????? ??????? ????? ??? ??????? ??? [9,10,1]?

????? ????

???? ????????? ??? ??????? ?? ???????????? ???????? ???? ????? ???????? ???????????? ???? ?????? ?????? ????????? ???? ????? ??? ????? ??????? ?????????? ????? ???? ????? ?????? ???????-?????? ????? ??????????? [11,12] : ???? ???? (????) ????? ??????? ??? ?????????? ???? ????????? ????? ?? RNA ?????????????? ???? ?????? ???????? ?????? (???????? ???? ????); ??? ??????????? [13,14] ?? ???? ???????? ??????????? ??????? (?????????, ????????) ???????? ???????? ?? ?? ???????? ????, ??? ????: ??????? ????-GPC ????????????????? ????????

??????????? ????????? ??? ??? ???????

?) ?????????? ??????

???-????????? ?????????? ????? ?????????? ???? ?????? ????? ?????? ???????? ???? ????? ??? ???? ?????????? ?????? ????? ??????? 14?? ????????? ???????? ????????? ???????? ?? CDP-??????? ???????? ??????? ?????? ???? ??????? ???? ???????? ????? ?????????? ???????? ???? ??????? ?????? ??? ?????? ????? ??????? [9]? 2,800 ?? ???? ????? ??????? ???? ???? ???? ???, ???????????? ???????? ????? ???, 21% ??????????? ?????? ?????? ??? ?????? ??? 45% ??????????? ?????? ????? ????? ??? ???????? ???????? ?????????? ???? ????, ???? ??? ??????? ??? ???? ???? ???? [18]? ???????????? (9 ??? ???? 1000mg) ?????? ?????????? ???????? ???? 350 ????? ??????????? ??????? ???? ???? ??? [19] ????? ???????: ?????????? ??????? ?????? ???? ???????????? ??? ???????? ???? ?????? ????? ???? ?????? ???????? ????? ????? ????????? ??? ???? ???????? ??????? ???? 210 ??????? ?????? ????????, CDP-??????? ??????, ??????????? ??? ??? ?????? ????? ???????? ????????????? ?????? (??????????) ???? ???? ???, ?????? ???? ?? ??? [??,??,??]? ???? ??? ?????????? ????? ?????, ??????????? ?????? ????? ??? ?????????? ??????? ?????? ???? ???????????? ??????? ??????? ?????? ?????? ??????? ?? ????? ????? ???? ?????? ?????? ?’? ?????... ??? ?? ????? ???????? ???? ????? ?????????? ?????????, ???????????? (???-?????????) ????? ??? ?????? ?????????? ????? ????? [??,??]? ???????? ??? CDP ???????? (??? ??????) ????? ?? ????? 60 ?? ??????????????????? ?????????? ??????????????? ?????? ????? ??? ??????????? ????? ????? ?????? ???????? ?? ??????? ??????? ??? ??? ??????? ????? ??????? [??]? ?? ?? ????? ???????? ??????, ????????????? ???? ?????? (??? ?????? ??????????) ??????? ?????????? ????????????? ????? ????? - ???????????? ???, ??????? ??? ????? ??????, ??????????????? ??????? - ?????? ???? ?????? ?????????? ?????? ???? ?????????? [??]? ???? ????????, ??????? ??????????? ??????????????? ???? ????? ?????? ???? ????? ??? ???? ??????????????????? ???? ??????? ?????? ?????????? ?????? ???? ????? [??] ????????? ????????? ?????????? ???????? ????? ???????? ?? ?? ?????????? ?????? ????????????? ???? ?? ????????, ???????????? (? ?????? ???? ???????? ???? ??????) ??????????? ??????????? ????? ??????? ????? ?????????? ??????????????? ?????? ???????? ????? ???????????? ?????? ????????? ?????????, ??? ????????? ??????? ???????? ?? ????????????? ?????? ????????? ???? ????? ????? ??????? ??????? ??????? [27,28]? ?????????? ?????? ???????, ???????????? ????? ??? ?????? ???????? ?????? ????????, ???????? ?????? ?????????? ?????? ???? ?????? ???????

?) ???????? ????????

?? ??????????? ???????? ??????? ???? ????? ???? ??????? ??????? ??????? ??? ?????????? ?????? ????? ???????????? ??????????? ?????? ???????? ????? ??? ??? ????? ???????? ????????? ????? ??? ??????? ??????? [29,30]? ?????? ?????????? ??????? (1,300 ?? ???? ????) ? ?? ????-???????? ???????, ???????? ??? 24 ????? ?????? 2000mg ??????????? ???? ?????? ?????????? ????? ????? ???????? 38% ?????? ????? [10]? 4,000 ?? ???? ???????? ????????? ?????????? ???? ?????? ?? ??????????? ????? ??? ???? ????????? ????? ???; ???? ?????? (2000-4000mg) ???? ??????????? ??? ???????? ????? ???????? ????????? ?????, ???? ????? ?????????? ???????? ???????????? ????? [31]? 3,000 ?? ???? ??????? ????? ?????? ????? ???????? ???? CDP-??????? ? ????? ?????????????? ??? ????? ????? [32,33]? ?????-?????? ????????? ????? ???????? ???? ????? ????? ????? ?????? ????? ????? ????????? ??? ????????? ???????? ?? ???????????? ???????? ??? ?????? ??????? ?????? ???????? ????????? ??????? ???????? ????? ??????? ??????, ????????? ??????? ??????? [34,35]? ???????????? ?????????? ?????? ???????? ???????????? ????? ???????, ?????? ?????? ?????? ????? ???????? ???? ?????-?????? ??? ????? ????? ????? ??????

?) ?????? ??????

???????? ??? ?????????? ???? ????????????? ??????? ???? ???, ??????????? ??????? ?????? ???? ???? ??????? ?????? ????????? ??? ?????? ????????? ??????? ????? ??????? ??? [1] ??? ????? ???? ?????????? ??????? ???????: ??????? ???????????? ???????? ??????????? ???????? ????? ??? ?????? ??? ???????? ?????????? ??????? ???????? ????? ??????? ???????? ??????? ??? ???????? ???????, ????? ????? ?????????? ??????? ????? ?????? [36]? 80 ?? ???????? ??????? ???? ????? ?????????? ?????????, ?????????? ??? ?????????? ?????? ????? ?????? ???????, ?????? ????? ????? ??????? ????? ???? ????????? ??? ??????? ??[37,38]? ?????????? ??? ????? ???? ????? ?????????? ????????? (68 ????) ???? ????? ????????? [39,40]? ???????????, ?????? "??? ???," ???????? ??? ???????? ??? ??? ???????? ?? ????? ??????? ?????? ?????? ??? ????? ????? ?????? ?????? ?????? ???????? [41] 190 ?? ??????? ?????? ?????????? ?????????, ??? ?????????? ???? ??????????? ???????? (??? ??????)?? ????? ??????? ??[42,43,44]? CDP ??????? ????????? (???????? 1000mg) ??????????? ????? 10 ?? ???????? ?????? ??????? ?????? ????? ??????? ????? ??????????? ????? ???????? ??? ??????? ????? ???? ??? ???? ??? ???????? ?????????? ???? ????, ???? ????? ????????? [45]? ??????? ?????????????? ??????? ?????? ????? ???? ?? ?????? ???? ????????????? ???? ?????? ???????? ??????? ?????????????? ???? 26 ?? ??????? ??????, ???????????? (2 ??? ???? 1600mg/???) ?????? ????? ?????? ??? ??????????? ????? ??????? ??[46]? ?????????? ?????? ????? ??? ??????? ???? ????? ?????? ???????? ???? ???????????? ????????? ?????? ????? ???? ????? ??? ?????????? ?????? ?????? ??????? ?????????? ?????? ??????, ???-?????? ??????, ?????? ?????-???????? ?????????? ???????? ?? ?????? ???????? ???? ???? ????? ????? ????? ?????, ??? ????????? ????? ????????? ????? ?????? ????? ????? ???????? ????? ????? ??????

?) ???????? ????

??????????? ???, ???????????? ??????????? ??? ???????? ??????? ?????? ???????? ????? ?????? ????? ???????????? ???????????? ?????????? ??????? ?????? ??????? ??? ??? ?????????????? ???????????????????????? ?????? ??? ???????? ??? ?????????? ??? ????? ????? ???? ??????? ??? ?????? ?????????? ?????????, ???????????? (?-? ??? ???? ???????? ??????????) ??????? ???? ???????????? ????? ????? [??,??,??]: ????? ?????? ????????????? ?????????? ???? ???????? ???????? ????? ?????????? ??? (??????????? ??? IL1B) ? ???? ????? ?????? ?????, ??? ???????? ???????? ?????????? ???? ??????? ????????? ?????? ????? ????????, ??????? ???? ???????? ??????????? ???? ???????? (APOE-e4 ????????) ????? ???? ??? ????? ????????? ??? ?? ?????????????? ?????? ???? APOE-e4 ???????? ??????? ????????? ????? ????? ????? (??? ??????? ????) ??????????? ?????? [??,??]? ???????????? ??????? ??? ???? ??? ????????? ???????? ?????? ??????? ????? ????? ????????????????? ??????? (??? ?? ???? ????) [??,??] ? ????????? ??? ???????? ??????? ????? ????? ??????????????, ???????????? ???????? ???????????? ???????? ??????? ??? ??? ???? ???????? ????? ???? ????????, ??????????? ?????????? ???????? ??? ??? ??????????? ????? ??????? [53]? ??????????? ??????? ???? ???????? ??? ???? ???????? ????? ??????? ??????? ???????, ?????? ???????? ?????????? ?????? ??????? ???????????? ??? ???????????? ????? ???????? ??????? ???? ???? ???? ???????? ??????, ????? ??? ???????? ????? ?????? ???? ???????????? ????? ????? ??????????????, ???????????? ?????????? ???????? ???? ?????? ??? ???????? ?????? ??? ???? ??? ???? ????????? ???????? ???? ?????? ??? [54,55]? ????????? ???????????? ????? ?????? ????? ??????? ????? ????????? ???? ????????? ???????????? ?????? ???????, ???? ???? ?????? ??????? ??? ?????????? ???????? ???? ???????? ????????? ???????????? ???? ????????????????, ????????????? ??????? ?????????? ??? ???? ???????? ?????? ????? ???? ???????????? ? ?????????? ???????????? ???????? [56,57]?

?) ?????? ????? ??? ???? ????

???????? 50 ?? ??????? ???? ?????????? ?? ????????, ?? ???????????????? (????????????) ???? ??????????? ????? ?????????? ????? ??? ???????? ?????? ??????? ??[58]? ??????????????, CDP-??????? ????????? ??????, ?????? ??? ??? ????????? ?????????????, ???????? ??? ?????????? ???? ?????? ?????? [59,60]? ?????????????? ??? ?????? ?????????? 60 ?? ?????????????? (????) ????????????????? ??????????? ?????????? ????? ????? ???????, ?????? ??? ??????? ???? ????? ?????? ????????? (3 ??? ???? 2000 ??????/???)? 31 ?? ?????????????? ????????????? ???? ???? ?? ????????, ??????????? ?????????? ???????? ??????? ????? ??? ??????? ????? ??????? ??[61,62]? ???????? ???????? ???? 130 ?? ???? ?????? ?????????????????, ??????????? (3 ??? ???? 500-2,000 ??????) ????? ??????? ????? ??????? ???????? ???????? ???????? ????????? ?????, 20 ?? ??????? ?????? ?????????????? ?? ?????????, ??? ????? ?????? ????????? [63,64,65]? ???? ???????? ????????? ??? ???????? ?? ?????????? ?????? ????, ???????? ?????? ???? ??????? ??? ???????, ?????? ??? ???? ?????????? ??????? ?????????? ??????? ??????? ??[66]? ??????????? ????????????? ???? 66 ?? ??????????? ???? ????????? ???????? ?????? ???????? ??? ???????? ??????, ???? ??????? ??? ?????? ??? "?????????" ???????????? ????? ??????? ????????? ??? ???? ???????? ???????? ????? ????? ?????? [67]? 24 ?? ????? ???????? ??????, CDP-??????? ?????????? ????????????? ?????????? ???????? ??? ??????? ?????? ???, ???? ???????? ??????????????? ????? [26]? ?????????? ?????? ??????????????????, ?????? ?????? ????? ??? ???? ????? ???????? ???? ??????????? ????????? ?????? ????? ???? ?????????? ?????? ??????