???? ????-??????? ????? ????? ??? ??????? ??????? ?? ??????????? ????????????? 1941 ???????, ????? ?????? ???? ??? ??????? ?? ?????? ???????? ??????? ???? ??? ????????? ????? ?????? ???? 1961 ??????? ???? ???? ?????????? ??? ?????? ???????? ????-??????? [1] ????? ?????? ???????? ????-???????? ?????? ???????????? ????, ???, ????????? ????? ??????? ???? ???????????, ???? ???? ???? ????-??????? ???????? ?????? ????? ???????? ?????, ????? ????? ??? ?????? ??????? ??????? ?????

β-??????? ??? ???? ??? ????? ?????? ???? ??????? ?????? ??? ???? ??????? ?????? ???? ???, β-??????? ??? ?????? ????? ???? 30% ?? 60% ???? ????, ??? ?????? ??????? ???? ??????, ?????????? ???????????? ???? ????, ????? ??????? ??????? ????? ??? ?????? ????????? ????? ???? ?????, ???? ?????? ??? ?????? ??????? ??? ???? ????????? ?????? ??? ???????? ?????????? ?? ???? β-???????? ??? ??????? β-1, 3-?????? ????, ??? β-1, 6-???? ??????????? ?? ??????????? ?????? ???? ????

???? ????-???????? ????????????????? ?????? ???? ???? ?????????, ?????????? ?????????? ??????? ??????????? ???????? ???? ?????? ????? ?????? ???? ?????? ???, ??? ???????????? ????????????? ????????????? ?????? ???? ??? ????????? ????? ?????????? ????????????? ????? ?????????? ??? ??? ?????????? ???????? ????????? ??????? ???? ????

????-??????? ??????? ?????? ????-??????? ???????? ?????? [4] ???? ?????? ??? ??????? ???: (1) ???????-1 ????????; (2) CR3; (3) ?????????? ???????? ??? LacCer ???? ???????? ????????? ???????? ???? β-??????? ???? ?????? ?????? ??? ??? ???????? ???? ?????? ???, ??? ???? ???????? ?????????? ???????? ?????????? ?????? (ITAM) ??? Syk ? ???????????? ?????? ????, ??? PI3K/Akt ???? ?????? ????, ???? ????? ?????????????, ???????????? ?????? ??? ?????????? ?????? ????? ??????, ???? ???? ?????? ?????????? ?? ????? ??? ??????????? ??? ?????? ???????????? ???????? ????????????? ??? ??'??? ??? ??????????? ?????? ??????

????-???????? ???? ????????? ??? ??????? ?????????? ??????????? ????????? ??? [6] :

?) ??????????????? ??????: β-????????? ??????????????? ??? ???, ???? ???????????? ??? ???????? ?????????????? ??????? ??????? (ROS) ???????? ???? ?????? ??? ?????? ??????????? ???? ??????? ????? ???????

2) ??????????? ??????: ???? ???? ????? ??? ????, β-???????? ????????? ?? ????? ?????? ???, ???? ?????????? ????? ?? ?????????? ???? ?????????? ????? ???? ?????? ????????, ?? ??????????? ????????? ??? ????????? (TEWL) ???????? ?? ??????? ????? ????????? ??? ????, ??? ????? ??????? ?? ???????????? ????????? ??? ???, ???? ?????? ???????? ??? ?????? ???? ??????? ??????? ????

3) ???? ?????? ??? ?????? ??????: Seo ??? ???????? ?????????? ?? ????-???????? ??????? ???? ???? ?????????????? (HaCaT) ??? ???? ???? ?????????????? (HDFa) ? ???????????? ??????????? ???????, ??? ????? ?????? ???? ???? ??? ????-?????????? ?????????? ??????? [7]? ??? ????, ????-???????? ?????-?????????? ??? ?????-?????????? ??? ?????? ??? ??????? ??? ??????? ??? ?????? ?????? ????? ??????? ??????? ???? ????????? ??? ?????????? ????????????? ?? ???????? ???????? ?? ????-??????? ?????? ??????? ???????????? (???????) ? ???????? ???? ?? ?????????? ????? [8]?

?) ?????????? ?????? ??????: ????-??????? ????? ?????????? ???????????? ????? ??????? ??????? ???, ??????? ?????? ??? ??????????? ??? ??????? ??? ???????? ???? ????? ????? ????????? (ECM) ????????????? ?????????? ??????????? ???, ???? ????? ???? ??? ??????? ?????? ????

??? ????, ????-???????? ???????? ???????? ????????? ?????, ?????????? ????? ?????, ??????? ???????? ?????, ???? ????????? ??????? ?????? ???? ??????

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