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??? ?? ?????? (CVD) ?????? ???? ??? ???? ?? ??? ????? ????? ??, ?? ????????, ?? 50 ??? ??? ??? ??? ?? ????? ???? ????? ?? ??, ??? ???????, ??? ?????? ?? ??? ??? ??? ?? ???????????? ?? ???? CVD ??????????? ?????????, ??? ??? ???????, ??? ??? ????????????? ????????? ???? ??? ????????? ??????? ??? ????? ???? ??? ?? ??, ?????? ?????? ??? ?????? ?????? ???? CVD ?? ???????? ???? ?? ???? ??? ?? ??? ?????? ?????? ???

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??? ?? ?? ??????? ????, ???? ???? ??????? ?? CVD ?? ?????? ??? ???? ?? ?????? ??????? ?? ????? ??? ????? ???? ??? ?????? ????? ?????? ?????? ?? ??? ???? ??? ?? ??????? ???? ????? ????????? ?? ??? ?????? ??????? ??, ?? ???? ??? '?? ??? ???? ??? ??????? ?????? ??? ?????? ???? ????? ??? ??????? ?? ?????? ?? ?? CVD ???? ?????? ????? ?????? ?? ????? ?? ????? ???? ????? ??: ??????? ??? ?????? ????, ??????????? ????????? ???? ???? ????, ????????? ???? ??? ????? ?????????? ??? ??????, ????????? ??? ?????, ??? ??? ???? ?????????? ??? ??????? ??? ???????/?????????? (I/R) ??? ??? ???????

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??? ??? ???? ??????????????? ?????? ??? '?? ???????? ??????? ?????? ??? ???? ??? ????? ??? ????? ?? ???????, ??? ????????? ???? ?????????? ???? '?? ????? ???? ??? ??????? ?? ?????? ??? ??? ?? ??? ???? ??? ? ???? ??? ?????????? (mTOR), ??? ?????/????????? ??????? ??????, ?? ?????? ??????? ?????? ????? ???? ????? ?????? ??????????? ?? ??? ????????? ???????? ??? mTOR ?? ??????????? ??????? ??? ????? ??, ???? ?? AMP-????????? ??????? ?????? (AMPK) ???? ??? '?? mTOR ??????? ??? ??? ??, ??????? ?? ??? ???????? ???????? ???? ??? ???? ???

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???????????? ??? ?????? ????????? ?? ?? ???? ???? ?????? ?? ?????? ???? ???? ????? ??, ????? ?? ???????, ????????, ??????? ??? ?????? ?? ???? ?? ?????? ?? ?????? ???? ??? ??, ??? ???? ???-??????, ????????????, ??????-???? ??? ??????-?????????? ?????? ????? ?? ??? ??? ??????? ????? ??? ??????? ?? ?????? ?? ?? ???????????? ?? ?????? ?? ?????? ????? AMPK ??? ????? ???? ??????? ??? ???????? ?? ???? ??? ?? ??? ?????, ???????????? mTOR ??????? 2(mTORC2) ???? ???? ??? ????? ???? ???? ???? ??? ??????? ?? ???? ???

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??????? ??? ???? ???? ????? ?????? ???? ??????, ??????? ??? ??? ??? ????? ????? ?? ??? ???? ?? ?????? ?? ????????????? ?????? ????? ??, ??? ???? ??? ??????, ???????????? ??? ??????? ????????? ????? ??? ??? AMPK ???????? ?? ??? '??, ??????? AMPK ??? ????? ???? ??????? ??? ??????? ?? ???? ?? ??? mTOR ??? ??? ?? ??????? ??? ?? ??? ???? ???

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???????? ??? ????? ?? ?? ???? ?????? ??? ??? ????? ?? ??? ???? ??? ???? ????? ????? ??? ???????? PI3K-AKT-mTOR ???????? ???? ??? ??? ??, AKT ??? mTOR ?? ???????????? ?????? ??? ??? ??, LC3-II ??? ??? ??, BECN1 ?? ???????? ??? ??? ??, BECN1 ??? BCL-2 ?????? ????? ?????? ??? ??? ??, ??? FoxO1 ?? ?????????? ??? ??? ?? ??????? ??? ??????? ?? ???? ???

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????????? ???? ??? ?????? ????? CVD ?? ?????????????? ???? ??? ???? ???? ??? ????? ??? ????? ???????? ???? ?????? ????? ?????? ?? ??? CVD ?? ??? ???? ???? ??? ????? ?? ???????? ???? CVD ?? ????? ??? ????? ??? ??? ???? ?? ??? ???? ?? ???? ???

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??? ?? ????? ??? ????? ???? ??????? ?? ??? ??? ????? ???-???????? ?????? ?? ??? ?? ???? ?? ?????? ?? ????????????? ?????? ??, ??? ???? ???????????? ??? ??? ?????? ????????? ????? ??? ??????? PPARγ, LXRα ??? ABCG1 ?? ???????? ??? ??? ???? ??, ?????????? ???? ?????????? ?? ????? ??? ?????? ?? ???? ??, ??? ?????????? LDL ????? ??????? ?????????? ?? ????? ??? ??? ??????????? ??? ??? ??? ???? ??, ?? ?????? ?????????? ???? ??? ?????? ?? ??? ??? ????? ???

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???????? ??? ?????? ??? '?? ??? ???? ???????? ?????????? ?? ?? ?????? ?? ?????????? ??? ????????? ???? ???? ????? ??, ??? ?? ??? ????????? ????? ?? ?????????? ??? ???? ?? ??????????? ???? ?? ???? ????? ??? ???????? ??????? ???? ????? ????? ?? ?? ???? ???????? ???????? CVD ???? ??? ??? ????? ???? ??? ???????? ?????????????? ?????? ??????? (ROS) ??? ????? ???? ??, ????-?????????? ??????????? ??? ??????????????? ?? ???????? ??????? ??? ??????? ??, ??????? ???????? ???? ?????? ??? ????? ??, ??? ????????? ??? ??????? ??? ???????? NF-κB ????????? ??? ??? ?? ????? ????????????? ??? ??? ???? ??, ??? ?? Nrf2/ARE ??????????????? ???? ??? ????? ???? ???????????? ??????????? ??? ?? ???????? ?? ???? ???

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???? ???????????? ???? ??? ????? ??? ?????????????? ???? ??? ???? ???? ??????? ??? ?? ?? ROS ??? ???? ???? ??, ??? ???? ????????? ?? ????? ??? ???? ???? ????? ???? ????????? ???, ????? ?? ????????, ??????? ??? ???????, ?? ???????????? ??????? ????? ??? [6]- ??????? PI3K/AKT ???????? ???? ??? ????? ???? ?????????? ?????????? (SOD) ??????? ??? ??? ???? ?? ??? ?????? ???? ?? ??????????????? ???? ROS ?????? ??? ??????????????? ??? ??? ??? ???? ??? ?? ??? ?????, 6-???????? ??? ????? ???? ?? ???????? Nrf2 ??? ??????? ???? ???????????? ?????? ?? ???? ??? ??? ??? '??, ???? ?? ???? ??????? ?????? ?? ?????? ?? ?????? ????? ??????? ???? ????? ??, ??? ???? ????????? ???? ??? ????? ??? ??????, ???????? ?????? (NO) ???????? ??? ??????, ???? ??????? ???????? ???? ?????? ??? ?????, ??? ??????? ??? ???????? ???? ????? ???

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??? ?? ??? ??? ????? ??? ???? ??????? ?????, ??? ???? ?????????? ?????????? ??????????? ????????? ????? ??, CVD ?? ????-????? ????-???? ??? ??????????? ????????? ???????? ????? ??? ??? ???????? ????? ????? ????? ?? ?? ?????????????? ???????????, ????????? ??? ??????????? ????? ??? ?? ????? ??, ????? ????? ???? ??? ???? ??????????? ??????, ?????? ??? ?? ??? ??? ??? ???? ??? ?? ?????? ???? ??? ??????????? II ?????????????? ??????????? ??? ???????? ???? ?? ??? ??????????? ?????? ??? ??????????? ???????? ??????? ???????? ??? ?????? ???? ??? AMPK CVD ?? ????? ???? ??? ???? ?????? ???????? ??, ??? AMPK ?? ??? ??? ?? ??????????? ??? ??????? ?? ??? ??? ??? ??? ?? ?????? ?? ????? ?????????? ??????? ???

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????????? ????????????? ????? ????? β1 (TGF-β1) ??????? ????????????? ??? ??????? ????????????? ???? ???? ??? ?? ??????? ??? ???? ??? ????????? ?????? ???????? ??? FoxO1 ??? ?????????????? ????? ?? ?? ?????????, ????????? ???? ??? ???? ???????? ???? ????? ??? TGF-β1 FoxO1 ???????? ??? ?????? ???? ??, ??? ??????? ????????????? ????, TGF-β1 FoxO1 ???????????? ??? ??????? ??, FoxO1 ???????? ???????? ??? ??????? ??, FoxO1 ??????? ?? ???? ??? ??????? ??, ??? ??????? ????????????? ??? ??????? ????????????? ???? ?????? ??? ???????? ???? ???

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??????? ??? ?????? ?????? ?? ?? ?????????? ?????????? ???? ??????? ?????? ??? ????? ????? ??? ??????? AMPK/TGF-β/Smads ???????? ?????? ??? ???????? ???? ???? ??????-??????? ??????? ????????? ??? ????? ??? ??????? ?? ???????? ???????? ???? AMPK/TGF-β/Smads ???????? ???? ??? ????? ???? ???? ??? ?? ????? ???? ??????? ????????? ?? ????? ????? ??? ??????? ?????????????? ??-???????? p300 ??? Smad3 ??? Smad3 ?? ???????? ????????????? ??? ?? ????? ??, ?? ?????? ??????????? II-?????? ??????? ????????? ?? ????? ??? ????? ???

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?????????? ??? ??? ???? ???? ????????? ????????? ?? ??? ??? ?????????? ???????????? ??? ?????????? ??????????? II ??? ???? ??????-???????? ??????? ??????????? ??? ??????? ??? ?????????? ??????????? II-??????? c-Fos ??? c-Jun ??????? ?? ???????? ??? ????? ??, ?? ?????? AP-1 ??????? ??? ????? ??? ?? ??? ?????, ?????????? ROS-????? p38 ??? JNK ???????? ?????? ??? ??? ?? NF-κB ??????? ??? ??? ???? ??, ??? AP-1 ????????? ?? ?????? ?????????? ????? EGFR ??????????????? ??? ???? ?????????? ?????? ERK/PI3K/AKT/mTOR/p70 ??? ??? ?? ??????? ??????????? ?? ?????? ??? ???? ?? ????? ??, ??? ??? ??? ???? ?????? ???????????? ??????? ??? ?????? ???????? ?? B-???? ?????? ??????????? ??? ????? ????? ?? ??? ??????? ??????????? ?????? ??? ????? ????? ??? ?????????? ??????????? II-??????? ROS ?????? ??? NADPH ??????? ???????? ??? ?? ????? ??, ?? ?????? ??????? ??????????? ??? ??????? ????????? ??? ????? ???

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?? ?????? ??? ???? ???????? ?? ?????? ??? ???? ?? ?????? ??????? ?? ??????? ?? ????? ????? ??? ?????-????? ????? ????? ?? ??? ???? ?? ??? ??, ??? ??? ??? ????? ??? ???? ???????? ??? ????? ???? ???? ?????? ?????? ?? ????? ??? ?????? ??????? ?? ????????? ???????????? ??? ??? ??????? ?? ???? ???-??? ???????? ?? ?????? ??? ???? ???? ????? ??? '?? ????? ???? ????? ???

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??????? ?? ?????? ?? ?? ?? ?????? ?? ?????? ??????? ????? ?? ????????????, ???????, ????????, ????????, ????, ???????, ??????????, ?????? ????, ????????, ?????, ????????? IIA ??? ????????? E ???? ??????? ??? ?????, ????????? ???? ??? ?????? ????? ??? ????, ??????????? ????????? ??? ????, ????????? ??? ????, ??? ???????/?????????? ??? ??? ???? ???? ?? ?????? ???? ???????? ??? ?? ?????? ????? mTOR, AMPK, NF-κB, Nrf2, ??? ???? ?? ?????? ?? ???????? ?????? ??? ????? ???? ??? ????????????? ??????? ?????? ???????? ???

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???????, ??????? ?????? ????? ??? ???? ???????? ?? ?????? ??? ??????? ?? ???? ???? ???? ????? ???? ??, ??? ?? ??? ???????? ??? ??????? ??? ?????? ????, ??? ?????? ??????? ?? ???-??????? ??? ??, ????? ?? ???? ???? ?????? ???? ???? ?? ??, ??? ??????? ???????????? ?? ??? ?????? ??? ?? ?????? ??? ?? ??? ?????, ???-??? ?????? ??????? ?????? ????? ?????? ?? ???? ??, ??? ????? ??? ???? ?? ???? ?? ??????? ?? ?? ??? ??? ?? ??? ????? ???