????????? ?? ??????? ?????? ???? ??? '?? ?????? ?????? ??? ????? ???? ?? ???? ??????????? ?????????? ???? ??? ???????? ??? ?? ?? ?? ?? ?????? ????????? ???? ????? ???? ??? ?????? ????? ??, ??? ????? ????? ?????? ??? ?????? ????? ??? ????????? ?? ??????? ?????? ?? ???? ??????????? ??? ?????? ????? ????? ????? ?? ??:

???? ???? ?????? ????: ???? ?????? ?????????? ????
???????? ???? ?????? ?? ???

???? ??????: ??? ?????? ????????? ???? (????? ?? ????????? ???????, ??????? ??????????) ??? ???? (????? ?? ?????????????????? ?????????????)?
??????? ??????????? ????????????: ?????? ???????? ??????? ??? ????? ???????? ?? ?????? ?? ????? ?????? ??????? ?? ??? ??? ??????? ???? ???????? ??? ??????? ???
???? ??? ?? ??????????

????? ????: ??????? ??? ??????? ??? ?? ????? ??? (30-35% ??? ?? ???????? ?? ???, ????????? ???????? ??? ???????? ??? ?? ??? ??? ??????? ??????? ??????? ??)?
???? ??? ??????: ???? ?? ????? ???? ???? ???? ??? ??? ??????????? ????????????? (α - ???????+???????) ????? ??????? ???? ???? ?? ??? ????? ???
?????????? ????????

?????? ???????? ??????????: ???? ?????????? ?????? ???? ????? ???????? ?????????? ???, pH (5.0-6.0), ?????? (28-34 ℃), ??? ???????? ?????? ?? ???? ??? ???? ??? ?????? ????
??? ??????? ???? ???????: ??? ??????? ???????? ?? ????, ???? ??? ???? ??????? ???? ??? ??????? ??? ?? ??? ??????? ??? ????????? ???? ????? ???
??? ??? ??? ????????? ?? ???? ???

????? ?? ?????? ?????
???????? ?????? ??? ?????? ??? ????????? ??? ????? ?? ?????? ?????????, ???????????????? ??? ??????????????
?????????????? ??????????? ????????? ????? ???????? ??? ??? ????? ??, ??? ??????? ?????? ?????? ????? ??? ??????? ??
????? ??????????????? ?????? ????????? ???????? ??? ????????????? → ?????? ??????????????? (??? ???? ??? ?????? ?? ??? ?????? ????)
??????????? ???????, ????????? ?? ??????????? ???????? → 99.5% ??? ??? ??????? ???? ????? ??????? ?????? ??? ?? ??? ???? ???????
?????? ??????? ??? ????-??? ?????? '?? ????? (???-???????)
??????? ??????? ?????? ?????????? '?? ????? ???? ??, ?? ????????? ?????? ??? '?? ????? ???? ????? ??:

??: ?????, ????????, ????? (???? 0.005-0.1% ??????)
???? ???? ????: ???? ???, ???
?????????? ?????????? ???? (????? ??????? ??? ??????? ??):
?????
??? ???? ???
?????? LR
A [????? ?????] -->B [??? ???? ?????]
B -->C [?????? ???? ???????????]
C -->D [??? ??????? ?????????????? ?????????]
D -->E [????????? ?? HPLC ????????]
??????: ???? ??? ??? (??? ??? ?????? ?????? ?? ??? ???????? ?????
????????? ???? ????????? ?????????/????????
?????????? ??????? ???????/??????? ???????????? ?????????????? (???????)
??????????????? ??????: ??????????? ??? ???? ???? (25 ℃ '?? 37 ?????/100 ????? ?? ??????????)? ???????? ??? ??????? ??? ???? ?? ????-???? ??????????? ??? ?? ??? ????? ???
???? ????: ?????? ???? ???? ???? ????? (?????? ?????
?????-????? ?? ?????: ???? ??? ?? ???? ??? 30% ??? ??? ????? ?? ??????? ??????? ??? ????????????? ?????????????? ??? ???? ?? ????????
?????? ??????????: ???? ????? ?????????? ?????? ?????? ?????? ???? ??, ?????????? ???? ??? 48 ?????? ??? ???? ???? ???
??? ???????????????: ?????????? ?????? ?????? ??????????????? ???????? ??????? ??????? (>99.9%) ??? ????? ??????? ?? ??? ???? ?? ??? ??? ??????? ???
?????
????????? ?? "??????????" ??? ???? ??????? ?????????? ??? ??? ?? ???????? ??? ???????? ??, ??? ?????? ?????????? ?? ????? ??????? ????? ??? ?????? ???????? ????? ??? ????? ?? ?? ???-???? ???? ?????? ??? ?????? ??? ?? ??????? ??? '?? ????????? ??????, ??? ???????? ??????????, ??? ?? ????????? ??????? ?? ????? ???? ??, ?? ?? ????? ????? ???? ?? ??? ??? ???? ???? ??? ???? ??? ???????? ?????? ??? ?????? ?????? ??????? ?? ??? ????? ??, ??? ??? ????? ?????? ?????? ???? ?? ???? ???