???????? ?????? ???? ???? ??????????? ???? ????? ???? ????? ??? ?????? ???? ????? ??? ???? ?????? ????? ????????? ???? ?? ???, ???????? ????? ?????? ?? ??? ????? ????? ??? ??? ???? ???? 1998 ???? FDA ????? ???? ??? ?? ??? ???????? ???? ??? ??? ????? ???? ?????? ?? ??? ???????? ????? ???? ????? ?? ???? ??, ??? ??? ???? ??????? ?? ???????? ??? ??????? ???? ???? ??? ????? ????? ???? ??????? ????? ?????? ???? ?? ???? ??? ?? ??? ?????, ???????? ?? ????? ????? ?? ?????? ???????? ????? ???? ???? ????? ??? ?? ???? ?? ???????? ????? ???? ???? ???? ?? ????? ??? ????? ?? ??? '?? ???????????? ?????? ?? ????? ??? ??? ???? ??, ??????????? ??? ??? ??? ???? ?????? ?????? ???????? ??? ??????? ?? ??????? ?? ?????? ?? ?? ???????? ?????? ????? ?? ?????? ????? ?? ?? ???? ??? ??????? '?? ???? ???? ?? ??? ?? ???????? ??? ?? ?????? ????????? '?? ???? ?? ???? ???? ?? ???????? ?? ?????? ?? ?? ???????? ?? ?????? ???? '?? ???? ?????? ???? ?????? ???? ???? ?? ??????? ?????????? ???? ??? ????, US FDA ?? ?????? ???? ?? ?? ?? ??? GRAS (???????) ????? ?????? ???

???????? ?? ????? 400 ??? ??? ?????? ?? ?????? ???? ????? ??? '?? ???? ????? ??? ??, ??? ???? ?????????? ??? ???? ?????, ?????????? ??? ???? ?????, ?????? ???? ??? ???? ?????, ??????? ???? ??? ???????, ???? ???? ???? ??? ???, ???, ???? ????, ??? ????, ????? ?????, ?????? ?? ???? ??? ??????? ????? ????? ????? ??? ??? ?????? ???? ??? ???? ????? ???? ????? ??????? ?? ?? ??? ???? ?????? ??, ??????? ?? 87 ?????? ?????? ????? ?????? ??? ?????? ???? ??? ???? ???? ??? ??????? ?? ???????? ??? ????? ???? ????? ??? ?????? ??? ?????? ???? ??? ???? ????? ???? ???? ??, ?? ????? ?? ?????? ?????? ?? ????? ??????? ?? ????? ???? ?????? ???? ???????? ?? ??? ??? ???? ???????